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    otomp otolith matrix protein [ Danio rerio (zebrafish) ]

    Gene ID: 565818, updated on 9-Dec-2024

    Summary

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    Official Symbol
    otompprovided by ZNC
    Official Full Name
    otolith matrix proteinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040709-1
    See related
    Ensembl:ENSDARG00000040306 AllianceGenome:ZFIN:ZDB-GENE-040709-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    omp; omp-1; zomp1; im:6904989; wu:fc44d11
    Summary
    Acts upstream of or within otolith development. Predicted to be located in extracellular region. Predicted to be active in endosome; extracellular space; and plasma membrane. Is expressed in epithalamus; otic vesicle; and vestibuloauditory system. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See otomp in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (41504752..41518340, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (41655412..41669000, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene heparan sulfate 6-O-sulfotransferase 1a Neighboring gene uncharacterized LOC137488025 Neighboring gene uncharacterized LOC110438100 Neighboring gene activin A receptor, type 1 like Neighboring gene D-2-hydroxyglutarate dehydrogenase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zona pellucida domain-containing protein β-tectorin is crucial for zebrafish proper inner ear development. Yang CH, et al. PLoS One, 2011. PMID 21829695, Free PMC Article
    2. Alteration of organ size and allometric scaling by organ-specific targeting of IGF signaling. Kamei H, et al. Gen Comp Endocrinol, 2021 Dec 1. PMID 34606746
    3. Otopetrin 1 is required for otolith formation in the zebrafish Danio rerio. Hughes I, et al. Dev Biol, 2004 Dec 15. PMID 15581873, Free PMC Article
    4. Otolith matrix proteins OMP-1 and Otolin-1 are necessary for normal otolith growth and their correct anchoring onto the sensory maculae. Murayama E, et al. Mech Dev, 2005 Jun. PMID 15905077
    5. Otoc1: a novel otoconin-90 ortholog required for otolith mineralization in zebrafish. Petko JA, et al. Dev Neurobiol, 2008 Feb 1. PMID 18000829, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in iron ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within otolith development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within otolith development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    otolith matrix protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045087.1 → NP_001038552.1  otolith matrix protein 1 precursor

      See identical proteins and their annotated locations for NP_001038552.1

      Status: PROVISIONAL

      Source sequence(s)
      AY681353
      UniProtKB/Swiss-Prot
      Q0VIL3, Q6DGA2
      Related
      ENSDARP00000106982.3, ENSDART00000130830.3
      Conserved Domains (2) summary
      smart00094
      Location:27 → 363
      TR_FER; Transferrin
      cd13529
      Location:27 → 363
      PBP2_transferrin; Transferrin family of the type 2 periplasmic-binding protein superfamily

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      41504752..41518340 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0VIL3.1 GenPept UniProtKB/Swiss-Prot:Q0VIL3

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