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    ccdc39 coiled-coil domain 39 molecular ruler complex subunit [ Danio rerio (zebrafish) ]

    Gene ID: 100005620, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ccdc39provided by ZNC
    Official Full Name
    coiled-coil domain 39 molecular ruler complex subunitprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-110603-1
    See related
    AllianceGenome:ZFIN:ZDB-GENE-110603-1
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Involved in cilium-dependent cell motility and epithelial cilium movement involved in determination of left/right asymmetry. Acts upstream of or within determination of left/right symmetry. Predicted to be located in cilium; cytoplasm; and cytoskeleton. Predicted to be active in axoneme. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 14. Orthologous to human CCDC39 (coiled-coil domain 39 molecular ruler complex subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ccdc39 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (7647911..7654870)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (7668678..7675642)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene receptor-interacting serine-threonine kinase 2 Neighboring gene receptor-interacting serine/threonine-protein kinase 2 Neighboring gene Y+L amino acid transporter 2 Neighboring gene wu:fc46h12 Neighboring gene DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Radial spoke proteins regulate otolith formation during early zebrafish development. Han X, et al. FASEB J, 2018 Jul. PMID 29475374
    2. CCDC39 is required for assembly of inner dynein arms and the dynein regulatory complex and for normal ciliary motility in humans and dogs. Merveille AC, et al. Nat Genet, 2011 Jan. PMID 21131972, Free PMC Article
    3. In vivo modeling of the morbid human genome using Danio rerio. Niederriter AR, et al. J Vis Exp, 2013 Aug 24. PMID 23995499, Free PMC Article
    4. The coiled-coil domain containing protein Ccdc136b antagonizes maternal Wnt/β-catenin activity during zebrafish dorsoventral axial patterning. Wei S, et al. J Genet Genomics, 2016 Jul 20. PMID 27477027
    5. Single-cell RNA analysis identifies pre-migratory neural crest cells expressing markers of differentiated derivatives. Lencer E, et al. Elife, 2021 Aug 16. PMID 34397384, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in axonemal dynein complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within cilium movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cilium-dependent cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium-dependent cell motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within determination of left/right symmetry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epithelial cilium movement involved in determination of left/right asymmetry IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in epithelial cilium movement involved in determination of left/right asymmetry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in inner dynein arm assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within inner dynein arm assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axoneme IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axoneme IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in axoneme ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    coiled-coil domain-containing protein 39
    Names
    coiled-coil domain containing 39

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001423814.1 → NP_001410743.1  coiled-coil domain-containing protein 39

      Status: VALIDATED

      Source sequence(s)
      BQ618148, CABZ01021592, EE323624
      UniProtKB/TrEMBL
      A0A8M1PVA8

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      7647911..7654870
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CK98.2 GenPept UniProtKB/Swiss-Prot:P0CK98

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.