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    hdx highly divergent homeobox [ Danio rerio (zebrafish) ]

    Gene ID: 797948, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hdxprovided by ZNC
    Official Full Name
    highly divergent homeoboxprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-140106-165
    See related
    Ensembl:ENSDARG00000079382 AllianceGenome:ZFIN:ZDB-GENE-140106-165
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable DNA binding activity. Predicted to be located in nucleus. Orthologous to human HDX (highly divergent homeobox). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See hdx in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (6209808..6229020, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (5902976..5922186, complement)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene BSCL2 lipid droplet biogenesis associated, seipin, like Neighboring gene si:ch73-22a13.3 Neighboring gene SMU1 DNA replication regulator and spliceosomal factor a Neighboring gene elongator acetyltransferase complex subunit 1 Neighboring gene TBC1 domain family, member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Pou3f transcription factor expression during embryonic development highlights distinct pou3f3 and pou3f4 localization in the Xenopus laevis kidney. Cosse-Etchepare C, et al. Int J Dev Biol, 2018. PMID 29877572
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    highly divergent homeobox
    Names
    zmp:0000001205

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001202494.1 → NP_001189423.1  highly divergent homeobox

      See identical proteins and their annotated locations for NP_001189423.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC124177, EB968358, EH606083, FP103005
      UniProtKB/TrEMBL
      A0A8M1P2K8, E7F5L7
      Related
      ENSDARP00000130885.1, ENSDART00000172665.2
      Conserved Domains (1) summary
      cl00084
      Location:16 → 70
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    2. NM_001202495.1 → NP_001189424.1  highly divergent homeobox

      See identical proteins and their annotated locations for NP_001189424.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      EB968358, EH606083, FP103005, FP103010
      UniProtKB/TrEMBL
      A0A8M1P2K8, E7F5L7
      Related
      ENSDARP00000102393.3, ENSDART00000111681.4
      Conserved Domains (1) summary
      cl00084
      Location:16 → 70
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      6209808..6229020 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021481070.2 → XP_021336745.1  highly divergent homeobox isoform X2

      UniProtKB/TrEMBL
      A0A8M9QP85
      Conserved Domains (1) summary
      cl00084
      Location:16 → 70
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    2. XM_068213257.1 → XP_068069358.1  highly divergent homeobox isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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