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    fstl1b follistatin-like 1b [ Danio rerio (zebrafish) ]

    Gene ID: 324309, updated on 9-Dec-2024

    Summary

    Official Symbol
    fstl1bprovided by ZNC
    Official Full Name
    follistatin-like 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-3029
    See related
    Ensembl:ENSDARG00000039576 AllianceGenome:ZFIN:ZDB-GENE-030131-3029
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fa95c03; fc25c04; wu:fa95c03; wu:fc25c04
    Summary
    Predicted to enable calcium ion binding activity and heparin binding activity. Acts upstream of or within dorsal/ventral pattern formation; notochord cell differentiation; and regulation of BMP signaling pathway. Predicted to be active in extracellular region. Is expressed in several structures, including axis; central nervous system; fin; head mesenchyme; and mesoderm. Orthologous to human FSTL1 (follistatin like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Genomic context

    See fstl1b in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (9735493..9842149, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (9757456..9864112, complement)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 156 Neighboring gene leucine rich repeat containing 58b Neighboring gene uncharacterized LOC137496420 Neighboring gene transcription termination factor, RNA polymerase II Neighboring gene protein arginine methyltransferase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within dorsal/ventral pattern formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within notochord cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within notochord development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of BMP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of BMP signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    follistatin-related protein 1b
    Names
    follistatin-like 2
    fstl2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039621.1NP_001034710.1  follistatin-related protein 1b precursor

      See identical proteins and their annotated locations for NP_001034710.1

      Status: PROVISIONAL

      Source sequence(s)
      DQ317971
      UniProtKB/TrEMBL
      A0A8M1N8A5, Q2PMI2
      Related
      ENSDARP00000105068.2, ENSDART00000121456.3
      Conserved Domains (4) summary
      smart00274
      Location:3052
      FOLN; Follistatin-N-terminal domain-like
      cd00104
      Location:5797
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
      pfam13499
      Location:148218
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:148218
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      9735493..9842149 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009304495.4XP_009302770.1  follistatin-related protein 1b isoform X1

      UniProtKB/TrEMBL
      A0A8M3BCA5
      Conserved Domains (4) summary
      smart00274
      Location:2951
      FOLN; Follistatin-N-terminal domain-like
      cd00104
      Location:5696
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
      pfam13499
      Location:147217
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:147217
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...