aep1 aerolysin-like protein [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: aep1provided by ZNC
Official Full Name: aerolysin-like proteinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050306-5
See related: Ensembl:ENSDARG00000039099 AllianceGenome:ZFIN:ZDB-GENE-050306-5
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: dln1; jac5; zgc:113413; zgc:174689
Summary: Enables D-mannose binding activity; disaccharide binding activity; and identical protein binding activity. Acts upstream of or within defense response to bacterium. Part of pore complex. Is expressed in several structures, including blood; heart; integument; liver; and pleuroperitoneal region. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: chromosome: 7

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (8373025..8374950, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (8127067..8128949, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

this study shows that the pore-forming protein Aep1 is an innate immune molecule that prevents zebrafish from bacterial infection
Title: The pore-forming protein Aep1 is an innate immune molecule that prevents zebrafish from bacterial infection.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables D-mannose binding	IDA Inferred from Direct Assay more info	PubMed
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables disaccharide binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cytokine production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within defense response to bacterium	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of pore complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: aerolysin-like protein

Names: jacalin-type lectin domain-containing protein 5; natterin-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013304.3 → NP_001013322.1 aerolysin-like protein

See identical proteins and their annotated locations for NP_001013322.1

Status: VALIDATED

Source sequence(s)

CR382283

UniProtKB/Swiss-Prot

Q5CZR5

Related

ENSDARP00000057100.3, ENSDART00000057101.5

Conserved Domains (2) summary

cd09302
Location:15 → 139

Jacalin_like; Jacalin-like lectin domain

cl03107
Location:157 → 285

ETX_MTX2; Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2