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    ppp2r3b protein phosphatase 2, regulatory subunit B'', beta [ Danio rerio (zebrafish) ]

    Gene ID: 566032, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ppp2r3bprovided by ZNC
    Official Full Name
    protein phosphatase 2, regulatory subunit B'', betaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070912-268
    See related
    Ensembl:ENSDARG00000076004 AllianceGenome:ZFIN:ZDB-GENE-070912-268
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:6895423; si:ch211-269e2.2
    Summary
    Predicted to enable protein phosphatase regulator activity. Acts upstream of or within bone mineralization. Predicted to be part of protein phosphatase type 2A complex. Is expressed in fast muscle cell; head; and somite. Used to study idiopathic scoliosis. Orthologous to human PPP2R3B (protein phosphatase 2 regulatory subunit B''beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human all
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    Genomic context

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    See ppp2r3b in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (34484453..34509967, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (34675268..34698516, complement)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene si:ch211-218d20.15 Neighboring gene si:ch211-269e2.1 Neighboring gene shox homeobox Neighboring gene cytokine receptor like factor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A CRISPR/Cas9-generated mutation in the zebrafish orthologue of PPP2R3B causes idiopathic scoliosis. Seda M, et al. Sci Rep, 2023 Apr 26. PMID 37100808, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within bone mineralization IMP
    Inferred from Mutant Phenotype
    more info
    		  
    Component Evidence Code Pubs
    part_of protein phosphatase type 2A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      34484453..34509967 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068223661.1 → XP_068079762.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1

      UniProtKB/TrEMBL
      A0A8N7TFB5, B0S5T6
      Related
      ENSDARP00000131183.1, ENSDART00000169114.2

    2. XM_005167860.4 → XP_005167917.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X2

      UniProtKB/TrEMBL
      A0A8M2BFY8
      Conserved Domains (1) summary
      pfam13499
      Location:329 → 427
      EF-hand_7; EF-hand domain pair

    3. XM_689298.9 → XP_694390.3  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1

      UniProtKB/TrEMBL
      A0A8N7TFB5, B0S5T6
      Conserved Domains (1) summary
      pfam13499
      Location:330 → 428
      EF-hand_7; EF-hand domain pair

    4. XM_021478995.2 → XP_021334670.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X5

      UniProtKB/TrEMBL
      A0A8M9QKA7
      Conserved Domains (1) summary
      pfam13499
      Location:252 → 354
      EF-hand_7; EF-hand domain pair

    5. XM_021478994.2 → XP_021334669.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X4

      UniProtKB/TrEMBL
      A0A8M9QBH6
      Related
      ENSDARP00000101930.3, ENSDART00000114043.4
      Conserved Domains (1) summary
      pfam13499
      Location:253 → 355
      EF-hand_7; EF-hand domain pair

    6. XM_021478993.2 → XP_021334668.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X3

      UniProtKB/TrEMBL
      A0A8M9Q569
      Conserved Domains (1) summary
      pfam13499
      Location:257 → 359
      EF-hand_7; EF-hand domain pair
    Nucleotide Protein Strain
    Heading Accession and Version

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