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    ighm immunoglobulin heavy constant mu [ Danio rerio (zebrafish) ]

    Gene ID: 378762, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ighmprovided by ZNC
    Official Full Name
    immunoglobulin heavy constant muprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030925-46
    See related
    AllianceGenome:ZFIN:ZDB-GENE-030925-46
    Gene type
    protein coding
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ighm1; wu:fj14a08; zgc:101769
    Summary
    Acts upstream of or within response to lipopolysaccharide. Is expressed in gut and immune system. Human ortholog(s) of this gene implicated in agammaglobulinemia 1. Orthologous to human IGHM (immunoglobulin heavy constant mu). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    not in current annotation release
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    Genomic context

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    Location:
    chromosome: 3

    Bibliography

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    Related articles in PubMed

    1. Discovery of an unusual alternative splicing pathway of the immunoglobulin heavy chain in a teleost fish, Danio rerio. Hu YL, et al. Dev Comp Immunol, 2011 Mar. PMID 21035505
    2. The whole-organism heavy chain B cell repertoire from Zebrafish self-organizes into distinct network features. Ben-Hamo R, et al. BMC Syst Biol, 2011 Feb 10. PMID 21310065, Free PMC Article
    3. In vitro neutralization of viral hemorrhagic septicemia virus by plasma from immunized zebrafish. Chinchilla B, et al. Zebrafish, 2013 Mar. PMID 23445428
    4. Molecular cloning and expression analysis of immunoglobulin M heavy chain gene of blunt snout bream (Megalobrama amblycephala). Xia H, et al. Fish Shellfish Immunol, 2014 Sep. PMID 24979225
    5. Identification and characterization of a novel immunoglobulin Z isotype in zebrafish: implications for a distinct B cell receptor in lower vertebrates. Hu YL, et al. Mol Immunol, 2010 Jan. PMID 19931913

    See all (94) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In present study, we identified a novel membrane immunoglobulin M isotype from zebrafish (Danio rerio)
      Title: Discovery of an unusual alternative splicing pathway of the immunoglobulin heavy chain in a teleost fish, Danio rerio.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Other Names

    • IgM
    • immunoglobulin heavy constant mu 1
    • mIgM-2

    Clone Names

    • MGC191870

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Names
    immunoglobulin heavy constant mu
    IgM
    immunoglobulin heavy constant mu 1
    mIgM-2
    Nucleotide Protein
    Heading Accession and Version

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