kif11 kinesin family member 11 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: kif11provided by ZNC
Official Full Name: kinesin family member 11provided by ZNC
Primary source: ZFIN:ZDB-GENE-020426-1
See related: Ensembl:ENSDARG00000010948 AllianceGenome:ZFIN:ZDB-GENE-020426-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb1; knsl1; sb:cb1; fa09c03; fb23c07; chunp6874; wu:fa09c03; wu:fb23c07
Summary: Predicted to enable plus-end-directed microtubule motor activity. Acts upstream of or within angiogenesis; neurogenesis; and regulation of cell cycle. Predicted to be located in spindle pole. Predicted to be active in mitotic spindle; nucleus; and spindle microtubule. Is expressed in several structures, including blood island; cardiovascular system; nervous system; pleuroperitoneal region; and radial glial cell. Human ortholog(s) of this gene implicated in microcephaly with or without chorioretinopathy, lymphedema, or mental retardation. Orthologous to human KIF11 (kinesin family member 11). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (19479471..19497162)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (19461302..19477170)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss-of-function of kinesin-5 KIF11 causes microcephaly, chorioretinopathy, and developmental disorders through chromosome instability and cell cycle arrest.
Title: Loss-of-function of kinesin-5 KIF11 causes microcephaly, chorioretinopathy, and developmental disorders through chromosome instability and cell cycle arrest.
Kif11 normally functions during mitotic spindle formation to facilitate the progression of radial glia through mitosis, which leads to the maturation of progeny into specific secondary neuronal and glial lineages in the developing neural tube.
Title: Kif11 dependent cell cycle progression in radial glial cells is required for proper neurogenesis in the zebrafish neural tube.

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General gene information

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Markers

fb23c07 (e-PCR)
- UniSTS:188976

fb23c07.x1 (e-PCR)
- UniSTS:203075

AA494615 (e-PCR)
- UniSTS:205404

fi57d02.x1 (e-PCR)
- UniSTS:197725

fc74g11.x1 (e-PCR)
- UniSTS:194435

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables plus-end-directed microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within microtubule-based movement	IEA Inferred from Electronic Annotation more info
involved_in mitotic spindle assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spindle elongation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in mitotic spindle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in spindle microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle pole	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: kinesin-like protein KIF11

Names: kinesin-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173261.2 → NP_775368.2 kinesin-like protein KIF11

Status: VALIDATED

Source sequence(s)

CU571091

UniProtKB/TrEMBL

A0A8M1PAA3, A0A8M9P014, F1QK82

Related

ENSDARP00000006884.8, ENSDART00000024194.9

Conserved Domains (3) summary

smart00129
Location:17 → 365

KISc; Kinesin motor, catalytic domain. ATPase

cd01364
Location:15 → 367

KISc_BimC_Eg5; Kinesin motor domain, BimC/Eg5 spindle pole proteins

pfam13931
Location:926 → 1061

Microtub_bind; Kinesin-associated microtubule-binding