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    uckl1a uridine-cytidine kinase 1-like 1a [ Danio rerio (zebrafish) ]

    Gene ID: 570547, updated on 9-Dec-2024

    Summary

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    Official Symbol
    uckl1aprovided by ZNC
    Official Full Name
    uridine-cytidine kinase 1-like 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040724-238
    See related
    Ensembl:ENSDARG00000001686 AllianceGenome:ZFIN:ZDB-GENE-040724-238
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    uckl1; zK70P6.2; si:dkey-70p6.2
    Summary
    Predicted to enable ATP binding activity and uridine kinase activity. Predicted to be involved in CTP salvage and UMP salvage. Predicted to act upstream of or within phosphorylation. Predicted to be active in cytoplasm. Orthologous to human UCKL1 (uridine-cytidine kinase 1 like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See uckl1a in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (23009662..23028542)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (22988423..23008668)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene elastin microfibril interfacer 3a Neighboring gene sterile alpha motif domain containing 10a Neighboring gene si:dkey-70p6.1 Neighboring gene sodium/potassium transporting ATPase interacting 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables uridine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in CTP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in UMP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uridine-cytidine kinase-like 1a
    Names
    uridine-cytidine kinase 1-like 1
    uridine/cytidine kinase-like 1
    NP_001121731.1
    XP_005167107.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128259.1 → NP_001121731.1  uridine-cytidine kinase-like 1a

      Status: PROVISIONAL

      Source sequence(s)
      BX649575
      UniProtKB/TrEMBL
      A0A8M1NH97, B0S7A4
      Related
      ENSDARP00000038740.6, ENSDART00000030885.7
      Conserved Domains (3) summary
      COG0572
      Location:79 → 286
      Udk; Uridine kinase [Nucleotide transport and metabolism]
      cd02023
      Location:80 → 279
      UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
      pfam14681
      Location:309 → 512
      UPRTase; Uracil phosphoribosyltransferase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      23009662..23028542
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005167050.5 → XP_005167107.1  uridine-cytidine kinase-like 1a isoform X1

      UniProtKB/TrEMBL
      A0A8M2BF24
      Conserved Domains (3) summary
      COG0572
      Location:93 → 300
      Udk; Uridine kinase [Nucleotide transport and metabolism]
      cd02023
      Location:94 → 293
      UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
      pfam14681
      Location:323 → 526
      UPRTase; Uracil phosphoribosyltransferase

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395272.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      257670..276480
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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