gadd45ba growth arrest and DNA-damage-inducible, beta a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gadd45baprovided by ZNC
Official Full Name: growth arrest and DNA-damage-inducible, beta aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1971
See related: Ensembl:ENSDARG00000027744 AllianceGenome:ZFIN:ZDB-GENE-040426-1971
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: CS131; cb196; gadd45b; gadd45b2; sb:cb196; zgc:73104; gadd45beta; wu:fa92d10; wu:fa98h12; wu:fk65h03; zgc:111973
Summary: Acts upstream of or within several processes, including regulation of podocyte apoptotic process; response to methylmercury; and somitogenesis. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including EVL; axis; cleithrum; mesoderm; and nervous system. Orthologous to human GADD45B (growth arrest and DNA damage inducible beta). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 11

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (6456146..6457748)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (6446307..6447909)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

investigated the functional effects of Coiled-Coil Domain Containing 80-loss-of-function during embryonic development and verified its interaction with gadd45beta2 in somitogenesis
Title: The Coiled-Coil Domain Containing 80 (ccdc80) gene regulates gadd45β2 expression in the developing somites of zebrafish as a new player of the hedgehog pathway.
regulated expression of gadd45beta genes in the anterior PSM is required for somite segmentation.
Title: Zebrafish GADD45beta genes are involved in somite segmentation.

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General gene information

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Markers

fa98h12.x1 (e-PCR)
- UniSTS:202630

fk65h03.x1 (e-PCR)
- UniSTS:201382

fa92d10.y1 (e-PCR)
- UniSTS:189658

Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
involved_in regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of podocyte apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to cadmium ion	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to methylmercury	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within somitogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: growth arrest and DNA-damage-inducible, beta a

Names: gadd; growth arrest and DNA damage 45 beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.