col1a2 collagen, type I, alpha 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: col1a2provided by ZNC
Official Full Name: collagen, type I, alpha 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-8415
See related: Ensembl:ENSDARG00000020007 AllianceGenome:ZFIN:ZDB-GENE-030131-8415
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zehn2357; alpha2(I); wu:fa98d05; wu:fa99g10; wu:fb04c08; wu:fb11d06; hm:zehn2357
Summary: Predicted to be an extracellular matrix structural constituent conferring tensile strength. Acts upstream of or within response to mechanical stimulus and skeletal system development. Predicted to be located in extracellular region. Predicted to be part of collagen type I trimer. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including cranium; dermomyotome; integument; muscle; and pectoral fin. Used to study Ehlers-Danlos syndrome and osteogenesis imperfecta. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome (multiple); heart valve disease; intracranial aneurysm; osteogenesis imperfecta (multiple); and osteoporosis. Orthologous to human COL1A2 (collagen type I alpha 2 chain). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 51

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (40983221..41002336)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (41396092..41415219)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dual function of perivascular fibroblasts in vascular stabilization in zebrafish.
Title: Dual function of perivascular fibroblasts in vascular stabilization in zebrafish.
ven though in adult bone, skin and scales equal amounts of a1(col1a1a) a2(col1a2) and a3(col1a2)chains are present, the presented data suggest a tissue-specific stoichiometry and/or post-translational modification status for collagen type I
Title: Zebrafish Collagen Type I: Molecular and Biochemical Characterization of the Major Structural Protein in Bone and Skin.

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General gene information

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Markers

fa98d05 (e-PCR)
- UniSTS:188936

fa99g10 (e-PCR)
- UniSTS:188960

AI617958 (e-PCR)
- UniSTS:206159

fb11d06.x1 (e-PCR)
- UniSTS:202835

AI331679 (e-PCR)
- UniSTS:206794

GDB:177260 (e-PCR)
- UniSTS:154850

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables extracellular matrix structural constituent	IEA Inferred from Electronic Annotation more info
enables extracellular matrix structural constituent conferring tensile strength	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to mechanical stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of collagen trimer	IEA Inferred from Electronic Annotation more info
part_of collagen type I trimer	IBA Inferred from Biological aspect of Ancestor more info
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: collagen alpha-2(I) chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_182968.2 → NP_892013.2 collagen alpha-2(I) chain precursor

See identical proteins and their annotated locations for NP_892013.2

Status: PROVISIONAL

Source sequence(s)

BC071278

UniProtKB/TrEMBL

A0A8M1P8M3, Q1LW91, Q6IQX2

Related

ENSDARP00000118091.1, ENSDART00000144544.3

Conserved Domains (2) summary

pfam01391
Location:936 → 995

Collagen; Collagen triple helix repeat (20 copies)

pfam01410
Location:1120 → 1351

COLFI; Fibrillar collagen C-terminal domain