hsd20b2 hydroxysteroid (20-beta) dehydrogenase 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hsd20b2provided by ZNC
Official Full Name: hydroxysteroid (20-beta) dehydrogenase 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030804-21
See related: Ensembl:ENSDARG00000031336 AllianceGenome:ZFIN:ZDB-GENE-030804-21
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sb:cb620; si:ch211-284e13.2
Summary: Enables androstan-3-alpha,17-beta-diol dehydrogenase activity. Acts upstream of or within multicellular organismal response to stress. Located in endoplasmic reticulum. Is expressed in several structures, including gill; heart; liver; pleuroperitoneal region; and sensory system. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (38200807..38214394)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (37600625..37613502)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our experiments show that 20b-HSD type 2, together with 11b-HSD type 2, represents a short pathway in zebrafish to rapidly inactivate and excrete cortisol. Therefore, 20beta-HSD type 2 is an important enzyme in stress response.
Title: Zebrafish 20β-hydroxysteroid dehydrogenase type 2 is important for glucocorticoid catabolism in stress response.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables androstan-3-alpha,17-beta-diol dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organismal response to stress	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within steroid biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: hydroxysteroid (20-beta) dehydrogenase 2

Names: 20beta-hydroxysteroid dehydrogenase type 2; SDR12C55

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001386628.1 → NP_001373557.1 hydroxysteroid (20-beta) dehydrogenase 2

Status: VALIDATED

Source sequence(s)

BX294181

UniProtKB/TrEMBL

A0A088Q715, A2BFP6

Related

ENSDARP00000091542.4, ENSDART00000100769.5

Conserved Domains (1) summary

cd05356
Location:54 → 296

17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs