U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    rfc3 replication factor C (activator 1) 3 [ Danio rerio (zebrafish) ]

    Gene ID: 259256, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    rfc3provided by ZNC
    Official Full Name
    replication factor C (activator 1) 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-020809-3
    See related
    Ensembl:ENSDARG00000055969 AllianceGenome:ZFIN:ZDB-GENE-020809-3
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb275
    Summary
    Predicted to enable ATP hydrolysis activity and DNA binding activity. Predicted to contribute to DNA clamp loader activity. Predicted to be involved in DNA repair and DNA-templated DNA replication. Predicted to act upstream of or within DNA replication. Predicted to be part of DNA replication factor C complex. Predicted to be active in nucleus. Is expressed in alar plate midbrain region; head; immature eye; optic tectum; and pectoral fin musculature. Orthologous to human RFC3 (replication factor C subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See rfc3 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (34024254..34033447, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (34080394..34089587, complement)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene furry homolog b (Drosophila) Neighboring gene uncharacterized LOC103911763 Neighboring gene zygote arrest 1-like Neighboring gene klotho Neighboring gene serine protease HTRA2, mitochondrial-like Neighboring gene serine protease HTRA2, mitochondrial-like

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Identification and expression analysis of the zebrafish orthologue of Klotho. Sugano Y, et al. Dev Genes Evol, 2011 Aug. PMID 21725870
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to DNA clamp loader activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA-templated DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of DNA replication factor C complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    replication factor C subunit 3

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201457.1 → NP_958865.1  replication factor C subunit 3

      See identical proteins and their annotated locations for NP_958865.1

      Status: PROVISIONAL

      Source sequence(s)
      BC042327
      UniProtKB/TrEMBL
      Q8AW06
      Related
      ENSDARP00000154572.1, ENSDART00000180734.1
      Conserved Domains (3) summary
      cd00009
      Location:21 → 179
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      PRK00440
      Location:3 → 345
      rfc; replication factor C small subunit; Reviewed
      pfam08542
      Location:250 → 337
      Rep_fac_C; Replication factor C C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      34024254..34033447 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394793.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      448061..457064 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.