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    rpp14 ribonuclease P/MRP 14 subunit [ Danio rerio (zebrafish) ]

    Gene ID: 553721, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rpp14provided by ZNC
    Official Full Name
    ribonuclease P/MRP 14 subunitprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050522-182
    See related
    Ensembl:ENSDARG00000011152 AllianceGenome:ZFIN:ZDB-GENE-050522-182
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7138188; zgc:112373; si:dkey-102c8.9
    Summary
    Predicted to enable (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity. Predicted to be involved in fatty acid biosynthetic process. Predicted to act upstream of or within tRNA 5'-leader removal. Predicted to be part of ribonuclease P complex. Predicted to be active in mitochondrion. Orthologous to several human genes including HTD2 (hydroxyacyl-thioester dehydratase type 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See rpp14 in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (10158463..10164866)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (10128635..10135184)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene biogenesis of lysosomal organelles complex-1, subunit 1 Neighboring gene TBC1 domain family, member 20 Neighboring gene RanBP-type and C3HC4-type zinc finger containing 1 Neighboring gene PX domain containing serine/threonine kinase Neighboring gene pyruvate dehydrogenase E1 subunit beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Inventory and analysis of the protein subunits of the ribonucleases P and MRP provides further evidence of homology between the yeast and human enzymes. Rosenblad MA, et al. Nucleic Acids Res, 2006. PMID 16998185, Free PMC Article
    2. Spatiotemporal compartmentalization of key physiological processes during muscle precursor differentiation. Ozbudak EM, et al. Proc Natl Acad Sci U S A, 2010 Mar 2. PMID 20160088, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC112373

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ribonuclease P activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within tRNA 5'-leader removal IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    part_of ribonuclease P complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribonuclease P protein subunit p14
    Names
    ribonuclease P 14 subunit
    NP_001018528.1
    XP_005174013.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001020692.2 → NP_001018528.1  ribonuclease P protein subunit p14

      See identical proteins and their annotated locations for NP_001018528.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the functional protein.
      Source sequence(s)
      BX324213
      UniProtKB/TrEMBL
      B2GSI4, Q502A2
      Related
      ENSDARP00000016855.8, ENSDART00000005869.9
      Conserved Domains (1) summary
      pfam01900
      Location:28 → 107
      RNase_P_Rpp14; Rpp14/Pop5 family

    RNA

    1. NR_144413.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses two alternate splice sites compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BX324213, EH542438, EH595656

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      10158463..10164866
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005173956.5 → XP_005174013.1  ribonuclease P protein subunit p14 isoform X1

      See identical proteins and their annotated locations for XP_005174013.1

      UniProtKB/TrEMBL
      B2GSI4, Q502A2
      Conserved Domains (1) summary
      pfam01900
      Location:28 → 107
      RNase_P_Rpp14; Rpp14/Pop5 family
    Nucleotide Protein Strain
    Heading Accession and Version

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