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    xiap X-linked inhibitor of apoptosis [ Danio rerio (zebrafish) ]

    Gene ID: 373108, updated on 9-Dec-2024

    Summary

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    Official Symbol
    xiapprovided by ZNC
    Official Full Name
    X-linked inhibitor of apoptosisprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030825-7
    See related
    Ensembl:ENSDARG00000016143 AllianceGenome:ZFIN:ZDB-GENE-030825-7
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    birc4; fb73d01; zgc:91873; wu:fb73d01
    Summary
    Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process and ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of apoptotic process; positive regulation of canonical Wnt signaling pathway; and positive regulation of protein ubiquitination. Predicted to be active in cytoplasm and nucleus. Is expressed in female organism; male organism; and testis. Human ortholog(s) of this gene implicated in X-linked lymphoproliferative syndrome 2 and prostate cancer. Orthologous to several human genes including XIAP (X-linked inhibitor of apoptosis). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See xiap in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (28473173..28483330)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (28167215..28177372)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene acyl-CoA synthetase long chain family member 4a Neighboring gene nuclear transport factor 2-like export factor 2 Neighboring gene proteasome 26S subunit, non-ATPase 10 Neighboring gene STAG2 cohesin complex component b Neighboring gene zgc:113364

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasis. Santoro MM, et al. Nat Genet, 2007 Nov. PMID 17934460
    2. Src-transformed cells hijack mitosis to extrude from the epithelium. Anton KA, et al. Nat Commun, 2018 Nov 8. PMID 30410020, Free PMC Article
    3. IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation. Oberoi TK, et al. EMBO J, 2012 Jan 4. PMID 22117219, Free PMC Article
    4. Yes-associated protein (yap) is required for early embryonic development in zebrafish (danio rerio). Hu J, et al. Int J Biol Sci, 2013. PMID 23494967, Free PMC Article
    5. Genes with homology to mammalian apoptosis regulators identified in zebrafish. Inohara N, et al. Cell Death Differ, 2000 May. PMID 10917738

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC91873

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase XIAP
    Names
    baculoviral IAP repeat-containing 4
    NP_919377.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_194396.2 → NP_919377.2  E3 ubiquitin-protein ligase XIAP

      See identical proteins and their annotated locations for NP_919377.2

      Status: PROVISIONAL

      Source sequence(s)
      BC133126
      UniProtKB/TrEMBL
      A2RV08
      Related
      ENSDARP00000018322.9, ENSDART00000017075.11
      Conserved Domains (2) summary
      cd00022
      Location:138 → 206
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      pfam13920
      Location:354 → 398
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      28473173..28483330
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394911.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      19363..29520
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001009908.1: Suppressed sequence

      Description
      NM_001009908.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version

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