tusc3 tumor suppressor candidate 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tusc3provided by ZNC
Official Full Name: tumor suppressor candidate 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-050522-381
See related: Ensembl:ENSDARG00000078854 AllianceGenome:ZFIN:ZDB-GENE-050522-381
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:110044
Summary: Acts upstream of or within magnesium ion transport. Predicted to be located in membrane. Predicted to be part of oligosaccharyltransferase complex. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 7. Orthologous to human TUSC3 (tumor suppressor candidate 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (16073887..16220235)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (15387374..15527298)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within magnesium ion transport	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tumor suppressor candidate 3

Names: unm_sa1726

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001020560.1 → NP_001018396.1 tumor suppressor candidate 3

See identical proteins and their annotated locations for NP_001018396.1

Status: PROVISIONAL

Source sequence(s)

BC095153

UniProtKB/TrEMBL

A0A0R4ISV3, A0A8N7XJA7, A0A8N7XJA8, E7FCL8, Q503W5

Related

ENSDARP00000137399.2, ENSDART00000160270.2

Conserved Domains (2) summary

cd02947
Location:39 → 136

TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...

pfam04756
Location:132 → 276

OST3_OST6; OST3 / OST6 family