mtmr8 myotubularin related protein 8 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mtmr8provided by ZNC
Official Full Name: myotubularin related protein 8provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1016
See related: Ensembl:ENSDARG00000008592 AllianceGenome:ZFIN:ZDB-GENE-040426-1016
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:56405; si:dkey-286f3.1
Summary: Enables MAP kinase kinase activity. Acts upstream of or within MAPK cascade; blood vessel development; and phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be located in nucleus. Predicted to be active in cytoplasm and nuclear envelope. Is expressed in several structures, including anterior axial hypoblast; immature eye; optic primordium; vasculature; and ventral mesoderm. Orthologous to human MTMR8 (myotubularin related protein 8). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human all
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Genomic context

Location:: chromosome: 5

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (22027588..22052852, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (21524586..21549052, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data indicate that Mtmr8 is essential for vasculature development in zebrafish embryos, and may play a role in arterial specification through repressing PI3K activity.
Title: Mtmr8 is essential for vasculature development in zebrafish embryos.
a conserved functional cooperation of Mtmr8 with PI3K regulates actin filament modeling and muscle development
Title: Cooperation of Mtmr8 with PI3K regulates actin filament modeling and muscle development in zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables MAP kinase kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,5-bisphosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3-phosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3-phosphate phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood vessel development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dephosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nuclear envelope	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR8; myotubularin-related protein 8

Names: myotubularin-related protein 6; phosphatidylinositol-3,5-bisphosphate 3-phosphatase; phosphatidylinositol-3-phosphate phosphatase

NP_956688.1

EC 3.1.3.95

XP_068077223.1

EC 3.1.3.95

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200394.1 → NP_956688.1 phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR8

See identical proteins and their annotated locations for NP_956688.1

Status: PROVISIONAL

Source sequence(s)

BC053411

UniProtKB/Swiss-Prot

Q6TEL0, Q7SZD1

Related

ENSDARP00000007263.6, ENSDART00000002938.7

Conserved Domains (2) summary

pfam06602
Location:109 → 446

Myotub-related; Myotubularin-like phosphatase domain

cl17171
Location:1 → 103

PH-like; Pleckstrin homology-like domain