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    serpina10b serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10b [ Danio rerio (zebrafish) ]

    Gene ID: 100003661, updated on 9-Dec-2024

    Summary

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    Official Symbol
    serpina10bprovided by ZNC
    Official Full Name
    serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-100716-5
    See related
    Ensembl:ENSDARG00000036968 AllianceGenome:ZFIN:ZDB-GENE-100716-5
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    serpina10; si:ch1073-416d2.3
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to act upstream of or within blood coagulation and negative regulation of peptidase activity. Predicted to be located in extracellular space. Human ortholog(s) of this gene implicated in thrombophilia. Orthologous to human SERPINA10 (serpin family A member 10). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See serpina10b in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (53291171..53295775)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (53203320..53208404)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene gamma-aminobutyric acid receptor subunit rho-1 Neighboring gene ataxin 3 Neighboring gene si:ch1073-416d2.4 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box helicase 24 Neighboring gene ankyrin repeat and SOCS box containing 2b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. High-Resolution Proteomic Profiling Shows Sexual Dimorphism in Zebrafish Heart-Associated Proteins. Niksirat H, et al. J Proteome Res, 2021 Aug 6. PMID 34185526
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blood coagulation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein Z-dependent protease inhibitor
    Names
    serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
    serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      53291171..53295775
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009293350.4 → XP_009291625.1  protein Z-dependent protease inhibitor

      UniProtKB/TrEMBL
      A0A8M3AK66
      Related
      ENSDARP00000141525.2, ENSDART00000170686.2
      Conserved Domains (1) summary
      pfam00079
      Location:35 → 392
      Serpin; Serpin (serine protease inhibitor)
    Nucleotide Protein Strain
    Heading Accession and Version

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