tinf2 TERF1 (TRF1)-interacting nuclear factor 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tinf2provided by ZNC
Official Full Name: TERF1 (TRF1)-interacting nuclear factor 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-6168
See related: Ensembl:ENSDARG00000054473 AllianceGenome:ZFIN:ZDB-GENE-030131-6168
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: TIN2; wu:fi37c10; zgc:158289
Summary: Predicted to enable telomeric DNA binding activity. Predicted to be involved in regulation of telomere maintenance via telomere lengthening and telomere capping. Predicted to be part of shelterin complex. Is expressed in several structures, including blastomere; digestive system; gill; heart; and ovary. Human ortholog(s) of this gene implicated in Revesz syndrome and autosomal dominant dyskeratosis congenita 3. Orthologous to human TINF2 (TERF1 interacting nuclear factor 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (24019493..24040061)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (23748336..23768900)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables telomeric DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in regulation of telomere maintenance via telomere lengthening	IBA Inferred from Biological aspect of Ancestor more info
involved_in telomere capping	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within telomere capping	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of shelterin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of shelterin complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: TERF1-interacting nuclear factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001386364.1 → NP_001373293.1 TERF1-interacting nuclear factor 2

Status: VALIDATED

Source sequence(s)

CR388231

UniProtKB/TrEMBL

A0A8M2BK53, F1R9M2

Related

ENSDARP00000113476.1, ENSDART00000141165.2

Conserved Domains (1) summary

pfam14973
Location:38 → 182

TINF2_N; TERF1-interacting nuclear factor 2 N-terminus

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007118.7 Reference GRCz11 Primary Assembly

Range

24019493..24040061

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009303073.3 → XP_009301348.1 TERF1-interacting nuclear factor 2 isoform X1

UniProtKB/TrEMBL

A0A8M3AU25

Conserved Domains (1) summary

cd11657
Location:8 → 196

TIN2_N; N-terminal domain of TRF-interacting nuclear factor 2; shelterin complex protein of telomeres

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001080027.1: Suppressed sequence

Description

NM_001080027.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from zebrafish: zgc:113263 (GeneID:503753).