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    pals2b protein associated with LIN7 2, MAGUK p55 family member b [ Danio rerio (zebrafish) ]

    Gene ID: 394134, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pals2bprovided by ZNC
    Official Full Name
    protein associated with LIN7 2, MAGUK p55 family member bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-775
    See related
    Ensembl:ENSDARG00000029761 AllianceGenome:ZFIN:ZDB-GENE-040426-775
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    mpp6; mpp6b; zgc:55662
    Summary
    Acts upstream of or within glial cell development and retina development in camera-type eye. Predicted to be located in membrane. Predicted to be active in cell-cell junction and plasma membrane. Is expressed in epiphysis and retina. Orthologous to human PALS2 (protein associated with LIN7 2, MAGUK p55 family member). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See pals2b in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (20060205..20106486, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (20475882..20522163, complement)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein-like 3a Neighboring gene gasdermin Ea Neighboring gene uncharacterized LOC137488505 Neighboring gene neuropeptide Y

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Microglial transglutaminase-2 drives myelination and myelin repair via GPR56/ADGRG1 in oligodendrocyte precursor cells. Giera S, et al. Elife, 2018 May 29. PMID 29809138, Free PMC Article
    2. Evolution of gonadotropin-inhibitory hormone receptor and its ligand. Ubuka T, et al. Gen Comp Endocrinol, 2014 Dec 1. PMID 25220854
    3. Structural diversity of the GnIH/GnIH receptor system in teleost: its involvement in early development and the negative control of LH release. Zhang Y, et al. Peptides, 2010 Jun. PMID 20226824
    4. The zebrafish NLRP3 inflammasome has functional roles in ASC-dependent interleukin-1β maturation and gasdermin E-mediated pyroptosis. Li JY, et al. J Biol Chem, 2020 Jan 24. PMID 31852739, Free PMC Article
    5. Evolution of the neuropeptide Y family: new genes by chromosome duplications in early vertebrates and in teleost fishes. Sundström G, et al. Gen Comp Endocrinol, 2008 Feb 1. PMID 17950734

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC55662

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within glial cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within retina development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    MAGUK p55 subfamily member 6b
    Names
    membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
    membrane protein, palmitoylated 6b (MAGUK p55 subfamily member 6)
    protein associated with LIN7 2, MAGUK family member b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044777.1 → NP_001038242.1  MAGUK p55 subfamily member 6b

      Status: PROVISIONAL

      Source sequence(s)
      BX640464
      UniProtKB/TrEMBL
      A0A8M1N987, F6P9A3, Q1LW94
      Related
      ENSDARP00000043923.5, ENSDART00000043924.7
      Conserved Domains (5) summary
      smart00569
      Location:2 → 55
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd11862
      Location:219 → 276
      SH3_MPP; Src Homology 3 domain of Membrane Protein, Palmitoylated (or MAGUK p55 subfamily member) proteins
      cd00992
      Location:128 → 206
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02828
      Location:57 → 108
      L27; L27 domain
      cl27059
      Location:336 → 526
      Guanylate_kin; Guanylate kinase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      20060205..20106486 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068215053.1 → XP_068071154.1  MAGUK p55 subfamily member 6b isoform X2

      UniProtKB/TrEMBL
      A0A8M9PAV5

    2. XM_005170013.5 → XP_005170070.1  MAGUK p55 subfamily member 6b isoform X1

      UniProtKB/TrEMBL
      A0A8M2BHB1
      Conserved Domains (6) summary
      smart00569
      Location:43 → 96
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd11862
      Location:260 → 317
      SH3_MPP; Src Homology 3 domain of Membrane Protein, Palmitoylated (or MAGUK p55 subfamily member) proteins
      smart00072
      Location:387 → 568
      GuKc; Guanylate kinase homologues
      cd00992
      Location:169 → 247
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:377 → 567
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:98 → 149
      L27; L27 domain

    3. XM_021468024.2 → XP_021323699.1  MAGUK p55 subfamily member 6b isoform X3

      UniProtKB/TrEMBL
      A0A8M1N987, F6P9A3, Q1LW94
      Conserved Domains (5) summary
      smart00569
      Location:2 → 55
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd11862
      Location:219 → 276
      SH3_MPP; Src Homology 3 domain of Membrane Protein, Palmitoylated (or MAGUK p55 subfamily member) proteins
      cd00992
      Location:128 → 206
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02828
      Location:57 → 108
      L27; L27 domain
      cl27059
      Location:336 → 526
      Guanylate_kin; Guanylate kinase
    Nucleotide Protein Strain
    Heading Accession and Version

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