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    podxl2 podocalyxin-like 2 [ Danio rerio (zebrafish) ]

    Gene ID: 563754, updated on 9-Dec-2024

    Summary

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    Official Symbol
    podxl2provided by ZNC
    Official Full Name
    podocalyxin-like 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6241
    See related
    AllianceGenome:ZFIN:ZDB-GENE-030131-6241
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fi40b04
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Located in apical plasma membrane. Is expressed in endothelial cell and podocyte. Orthologous to human PODXL2 (podocalyxin like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See podxl2 in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (5587474..5631017, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (4157826..4183585, complement)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene natural killer cell receptor 2B4-like Neighboring gene zgc:171566 Neighboring gene minichromosome maintenance complex component 2 Neighboring gene coiled-coil domain containing 51

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Distinct cellular mechanisms of blood vessel fusion in the zebrafish embryo. Herwig L, et al. Curr Biol, 2011 Nov 22. PMID 22079115
    2. A noncanonical function of histidyl-tRNA synthetase: inhibition of vascular hyperbranching during zebrafish development. Ni R, et al. FEBS Open Bio, 2018 May. PMID 29744287, Free PMC Article
    3. Distinct and redundant functions of Esama and VE-cadherin during vascular morphogenesis. Sauteur L, et al. Development, 2017 Apr 15. PMID 28264837
    4. Formin-mediated actin polymerization at endothelial junctions is required for vessel lumen formation and stabilization. Phng LK, et al. Dev Cell, 2015 Jan 12. PMID 25584798
    5. Defects of CRB2 cause steroid-resistant nephrotic syndrome. Ebarasi L, et al. Am J Hum Genet, 2015 Jan 8. PMID 25557779, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    podocalyxin-like protein 2
    Names
    pdxl2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      5587474..5631017 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_687115.9 → XP_692207.6  podocalyxin-like protein 2

      UniProtKB/TrEMBL
      A0A8N7TDD8
      Conserved Domains (3) summary
      pfam00014
      Location:99 → 150
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam06365
      Location:375 → 586
      CD34_antigen; CD34/Podocalyxin family
      cl26386
      Location:185 → 339
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    Nucleotide Protein Strain
    Heading Accession and Version

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