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    ywhaqb tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b [ Danio rerio (zebrafish) ]

    Gene ID: 335195, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ywhaqbprovided by ZNC
    Official Full Name
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-7135
    See related
    Ensembl:ENSDARG00000023323 AllianceGenome:ZFIN:ZDB-GENE-030131-7135
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ywhaz; ywhaq1; zgc:55499; wu:fa91b01; wu:fb02e12; wu:fb36f06; wu:fk86h02
    Summary
    Predicted to enable monooxygenase activity. Predicted to be involved in protein localization and signal transduction. Predicted to be active in cytoplasm. Is expressed in several structures, including nervous system; optic vesicle; pleuroperitoneal region; solid lens vesicle; and tail bud. Human ortholog(s) of this gene implicated in transitional cell carcinoma and vulva squamous cell carcinoma. Orthologous to several human genes including YWHAQ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ywhaqb in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (32500452..32525649)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (32547941..32573138)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488118 Neighboring gene Kruppel like factor 11b Neighboring gene grainyhead-like transcription factor 1 Neighboring gene GC-rich sequence DNA-binding factor 2 Neighboring gene uncharacterized LOC108179784

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Comprehensive Analysis of Neurotoxin-Induced Ablation of Dopaminergic Neurons in Zebrafish Larvae. Kalyn M, et al. Biomedicines, 2019 Dec 28. PMID 31905670, Free PMC Article
    2. A triple-drug nanotherapy to target breast cancer cells, cancer stem cells, and tumor vasculature. El-Sahli S, et al. Cell Death Dis, 2021 Jan 4. PMID 33414428, Free PMC Article
    3. Neuroprotective effects of nanogold-based Ayurveda medicine Suvarna Bhasma against rotenone-induced Parkinson's-like model. Biswas S, et al. J Ayurveda Integr Med, 2024 Jan-Feb. PMID 38145607, Free PMC Article
    4. Assessment of toxicity and genotoxicity of low doses of 5-fluorouracil in zebrafish (Danio rerio) two-generation study. Kovács R, et al. Water Res, 2015 Jun 15. PMID 25889180
    5. Validation of zebrafish (Danio rerio) reference genes for quantitative real-time RT-PCR normalization. Tang R, et al. Acta Biochim Biophys Sin (Shanghai), 2007 May. PMID 17492136, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b
    Names
    tryosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 1
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201484.1 → NP_958892.1  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b

      See identical proteins and their annotated locations for NP_958892.1

      Status: PROVISIONAL

      Source sequence(s)
      BC044412
      UniProtKB/TrEMBL
      A0A2R8QKG9, F6P3J2, Q803M8
      Related
      ENSDARP00000022550.7, ENSDART00000018423.8
      Conserved Domains (1) summary
      cd10023
      Location:1 → 234
      14-3-3_theta; 14-3-3 theta/tau (theta in mice, tau in human), an isoform of 14-3-3 protein

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      32500452..32525649
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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