U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    sptb spectrin, beta, erythrocytic [ Danio rerio (zebrafish) ]

    Gene ID: 58040, updated on 4-Jan-2025

    Summary

    Go to the top of the page Help
    Official Symbol
    sptbprovided by ZNC
    Official Full Name
    spectrin, beta, erythrocyticprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-000906-1
    See related
    Ensembl:ENSDARG00000030490 AllianceGenome:ZFIN:ZDB-GENE-000906-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fa09g12; wu:fa09g12
    Summary
    Predicted to enable actin binding activity and phospholipid binding activity. Predicted to be a structural constituent of cytoskeleton. Acts upstream of or within embryonic hemopoiesis and erythrocyte development. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be part of spectrin. Is expressed in intermediate cell mass of mesoderm. Human ortholog(s) of this gene implicated in hereditary spherocytosis and hereditary spherocytosis type 2. Orthologous to human SPTB (spectrin beta, erythrocytic). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See sptb in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (38566652..38601051)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (38619074..38651427)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene codanin 1 Neighboring gene StAR-related lipid transfer (START) domain containing 9 Neighboring gene coiled-coil domain containing 88C Neighboring gene ovarian cancer G-protein coupled receptor 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Characterization of zebrafish mutants with defects in embryonic hematopoiesis. Ransom DG, et al. Development, 1996 Dec. PMID 9007251
    2. Novel immunologic tolerance of human cancer cell xenotransplants in zebrafish. Zhang B, et al. Transl Res, 2016 Apr. PMID 26746804
    3. Novel zebrafish caspase-3 substrates. Valencia CA, et al. Biochem Biophys Res Commun, 2007 Sep 21. PMID 17643392
    4. Distinct roles for SCL in erythroid specification and maturation in zebrafish. Juarez MA, et al. J Biol Chem, 2005 Dec 16. PMID 16210319
    5. Gfi1aa/Lsd1 Facilitates Hemangioblast Differentiation Into Primitive Erythrocytes by Targeting etv2 and sox7 in Zebrafish. Wu M, et al. Front Cell Dev Biol, 2021. PMID 35096818, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin filament capping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in actin filament capping IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within embryonic hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within erythrocyte development IMP
    Inferred from Mutant Phenotype
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spectrin IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    spectrin beta chain, erythrocytic
    Names
    b-spectrin
    beta-spectrin
    riesling
    ris

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131525.1 → NP_571600.1  spectrin beta chain, erythrocytic

      See identical proteins and their annotated locations for NP_571600.1

      Status: PROVISIONAL

      Source sequence(s)
      AF262336
      UniProtKB/TrEMBL
      Q9DGM6
      Related
      ENSDARP00000040626.5, ENSDART00000040627.6
      Conserved Domains (5) summary
      cd00014
      Location:182 → 285
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:538 → 749
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd10571
      Location:2204 → 2309
      PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:2202 → 2309
      PH; PH domain
      pfam00435
      Location:430 → 532
      Spectrin; Spectrin repeat

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      38566652..38601051
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005158850.4 → XP_005158907.1  spectrin beta chain, erythrocytic isoform X2

      See identical proteins and their annotated locations for XP_005158907.1

      UniProtKB/TrEMBL
      A0A8M2B5U4, F1QQE5
      Related
      ENSDARP00000113965.1, ENSDART00000145147.4
      Conserved Domains (5) summary
      cd00014
      Location:182 → 285
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:538 → 749
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd10571
      Location:2204 → 2309
      PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:2202 → 2309
      PH; PH domain
      pfam00435
      Location:430 → 532
      Spectrin; Spectrin repeat

    2. XM_005158851.5 → XP_005158908.1  spectrin beta chain, erythrocytic isoform X2

      See identical proteins and their annotated locations for XP_005158908.1

      UniProtKB/TrEMBL
      A0A8M2B5U4, F1QQE5
      Conserved Domains (5) summary
      cd00014
      Location:182 → 285
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:538 → 749
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd10571
      Location:2204 → 2309
      PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:2202 → 2309
      PH; PH domain
      pfam00435
      Location:430 → 532
      Spectrin; Spectrin repeat

    3. XM_005158849.5 → XP_005158906.1  spectrin beta chain, erythrocytic isoform X1

      UniProtKB/TrEMBL
      A0A8M2B5B6
      Conserved Domains (5) summary
      cd00014
      Location:306 → 409
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:662 → 873
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd10571
      Location:2328 → 2433
      PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:2326 → 2433
      PH; PH domain
      pfam00435
      Location:554 → 656
      Spectrin; Spectrin repeat
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools