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    fxyd11 FXYD domain containing ion transport regulator 11 [ Danio rerio (zebrafish) ]

    Gene ID: 569335, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fxyd11provided by ZNC
    Official Full Name
    FXYD domain containing ion transport regulator 11provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-33
    See related
    Ensembl:ENSDARG00000099117 AllianceGenome:ZFIN:ZDB-GENE-030131-33
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zeh0312; hm:zeh0312; si:dkey-33i11.4
    Summary
    Predicted to enable ion channel regulator activity. Predicted to act upstream of or within monoatomic ion transport and regulation of monoatomic ion transport. Located in membrane. Is expressed in NaK ionocyte; gill; gill ionocyte; and gill lamella. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See fxyd11 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (45228098..45235932, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (45261382..45269216, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene si:dkey-33i11.9 Neighboring gene FXYD domain containing ion transport regulator 3 Neighboring gene hepsin Neighboring gene myelin-associated glycoprotein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification of zebrafish Fxyd11a protein that is highly expressed in ion-transporting epithelium of the gill and skin and its possible role in ion homeostasis. Saito K, et al. Front Physiol, 2010. PMID 21423371, Free PMC Article
    2. The zebrafish reference genome sequence and its relationship to the human genome. Howe K, et al. Nature, 2013 Apr 25. PMID 23594743, Free PMC Article
    3. Na(+) K(+) ATPase isoform switching in zebrafish during transition to dilute freshwater habitats. Esbaugh AJ, et al. Proc Biol Sci, 2019 May 29. PMID 31113326, Free PMC Article
    4. Identification, characterization, and mapping of expressed sequence tags from an embryonic zebrafish heart cDNA library. Ton C, et al. Genome Res, 2000 Dec. PMID 11116087, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ion channel regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sodium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of sodium ion export across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    FXYD domain-containing ion transport regulator 11
    Names
    FXYD domain containing ion transport regulator-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282018.1 → NP_001268947.1  FXYD domain-containing ion transport regulator 11 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001268947.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
      Source sequence(s)
      EH447516, EH457718
      UniProtKB/Swiss-Prot
      C0HJJ0
      UniProtKB/TrEMBL
      X5IY73
      Related
      ENSDARP00000137233.1, ENSDART00000164436.2
      Conserved Domains (1) summary
      pfam02038
      Location:21 → 63
      ATP1G1_PLM_MAT8; ATP1G1/PLM/MAT8 family

    2. NM_001282020.1 → NP_001268949.1  FXYD domain-containing ion transport regulator 11 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      EH447516, EH449767
      UniProtKB/Swiss-Prot
      C0HJJ0
      Related
      ENSDART00000168966.2
      Conserved Domains (1) summary
      pfam02038
      Location:21 → 61
      ATP1G1_PLM_MAT8; ATP1G1/PLM/MAT8 family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      45228098..45235932 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    C0HJJ0.1 GenPept UniProtKB/Swiss-Prot:C0HJJ0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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    Research Materials