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    kif4 kinesin family member 4 [ Danio rerio (zebrafish) ]

    Gene ID: 393796, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kif4provided by ZNC
    Official Full Name
    kinesin family member 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1545
    See related
    Ensembl:ENSDARG00000005462 AllianceGenome:ZFIN:ZDB-GENE-040426-1545
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:66125
    Summary
    Predicted to enable microtubule motor activity. Predicted to be involved in mitotic spindle organization and spindle elongation. Predicted to act upstream of or within microtubule-based movement. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be part of microtubule associated complex. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 100. Orthologous to human KIF4A (kinesin family member 4A) and KIF4B (kinesin family member 4B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See kif4 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (44737594..44772729, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (44713348..44748483, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene sprouty homolog 4 (Drosophila) Neighboring gene AMMECR nuclear protein 1 Neighboring gene ring finger protein 121 Neighboring gene follistatin-like 4 Neighboring gene Rap guanine nucleotide exchange factor (GEF) 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RING finger protein 121 facilitates the degradation and membrane localization of voltage-gated sodium channels. Ogino K, et al. Proc Natl Acad Sci U S A, 2015 Mar 3. PMID 25691753, Free PMC Article
    2. Surface functionalities of gold nanoparticles impact embryonic gene expression responses. Truong L, et al. Nanotoxicology, 2013 Mar. PMID 22263968, Free PMC Article
    3. Single-cell mapping of gene expression landscapes and lineage in the zebrafish embryo. Wagner DE, et al. Science, 2018 Jun 1. PMID 29700229, Free PMC Article
    4. On the crucial cerebellar wound healing-related pathways and their cross-talks after traumatic brain injury in Danio rerio. Wu CC, et al. PLoS One, 2014. PMID 24926785, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC66125

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spindle elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of microtubule associated complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kinesin family member 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200823.1 → NP_957117.1  kinesin family member 4

      See identical proteins and their annotated locations for NP_957117.1

      Status: PROVISIONAL

      Source sequence(s)
      BC060673
      UniProtKB/TrEMBL
      Q6P9P4
      Related
      ENSDARP00000012856.7, ENSDART00000026178.8
      Conserved Domains (5) summary
      smart00129
      Location:10 → 345
      KISc; Kinesin motor, catalytic domain. ATPase
      cd01372
      Location:9 → 339
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam03638
      Location:1100 → 1136
      TCR; Tesmin/TSO1-like CXC domain, cysteine-rich domain
      pfam11917
      Location:938 → 1082
      DUF3435; Protein of unknown function (DUF3435)
      pfam16716
      Location:568 → 644
      BST2; Bone marrow stromal antigen 2

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      44737594..44772729 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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