ythdf1 YTH N6-methyladenosine RNA binding protein F1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ythdf1provided by ZNC
Official Full Name: YTH N6-methyladenosine RNA binding protein F1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2786
See related: Ensembl:ENSDARG00000016447 AllianceGenome:ZFIN:ZDB-GENE-040426-2786
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb49c02; zgc:55657; wu:fb49c02; wu:fi19h06; wu:fj87f09; wu:fp06c11
Summary: Enables mRNA 3'-UTR binding activity. Predicted to be involved in mRNA destabilization. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human YTHDF1 (YTH N6-methyladenosine RNA binding protein F1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (23105180..23119981)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (23083882..23098975)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fi19g06.x1 (e-PCR)
- UniSTS:196983

fb49c02.x1 (e-PCR)
- UniSTS:203238

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables N6-methyladenosine-containing RNA reader activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in mRNA destabilization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: YTH domain-containing family protein 1

Names: YTH N(6)-methyladenosine RNA binding protein 1; YTH domain family, member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212713.1 → NP_997878.1 YTH domain-containing family protein 1

See identical proteins and their annotated locations for NP_997878.1

Status: PROVISIONAL

Source sequence(s)

BC046885

UniProtKB/TrEMBL

A0A8N7V0A6, Q802Z0

Related

ENSDARP00000005746.8, ENSDART00000025171.9

Conserved Domains (1) summary

pfam04146
Location:430 → 563

YTH; YT521-B-like domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007119.7 Reference GRCz11 Primary Assembly

Range

23105180..23119981

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005167004.5 → XP_005167061.1 YTH domain-containing family protein 1 isoform X1

UniProtKB/TrEMBL

A0A8M2BEG4

Conserved Domains (1) summary

pfam04146
Location:430 → 563

YTH; YT521-B-like domain