gja8b gap junction protein alpha 8 paralog b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gja8bprovided by ZNC
Official Full Name: gap junction protein alpha 8 paralog bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-010607-3
See related: Ensembl:ENSDARG00000015076 AllianceGenome:ZFIN:ZDB-GENE-010607-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cx44.1; zfCx44.1; zgc:110520
Summary: Enables gap junction hemi-channel activity. Acts upstream of or within lens development in camera-type eye. Predicted to be located in plasma membrane. Predicted to be part of connexin complex. Is expressed in several structures, including eye; kidney; liver; solid lens vesicle; and spinal cord. Human ortholog(s) of this gene implicated in cataract and cataract 1 multiple types. Orthologous to human GJA8 (gap junction protein alpha 8). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (47446134..47448850)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (46754902..46757618)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rapamycin relieves the cataract caused by ablation of Gja8b through stimulating autophagy in zebrafish.
Title: Rapamycin relieves the cataract caused by ablation of Gja8b through stimulating autophagy in zebrafish.
Cx48.5, Cx44.1, Cx43 have roles in lens development
Title: Expression of connexin48.5, connexin44.1, and connexin43 during zebrafish (Danio rerio) lens development.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables gap junction channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables gap junction hemi-channel activity	IDA Inferred from Direct Assay more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell communication	IEA Inferred from Electronic Annotation more info
involved_in cell-cell signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in gap junction-mediated intercellular transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lens development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
part_of connexin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of connexin complex	IC Inferred by Curator more info
part_of connexin complex	IEA Inferred from Electronic Annotation more info
located_in gap junction	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: gap junction protein alpha 8 paralog b

Names: connexin 44.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131809.2 → NP_571884.2 gap junction protein alpha 8 paralog b

See identical proteins and their annotated locations for NP_571884.2

Status: PROVISIONAL

Source sequence(s)

BC095304

UniProtKB/TrEMBL

A0A8M1P965, Q503J6

Related

ENSDARP00000026053.8, ENSDART00000007262.9

Conserved Domains (5) summary

smart00037
Location:44 → 76

CNX; Connexin homologues

smart01089
Location:167 → 233

Connexin_CCC; Gap junction channel protein cysteine-rich domain

pfam00029
Location:3 → 234

Connexin; Connexin

pfam03509
Location:268 → 334

Connexin50; Gap junction alpha-8 protein (Cx50)

pfam16791
Location:369 → 391

Connexin40_C; Connexin 40 C-terminal domain