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    snx2 sorting nexin 2 [ Danio rerio (zebrafish) ]

    Gene ID: 568737, updated on 9-Dec-2024

    Summary

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    Official Symbol
    snx2provided by ZNC
    Official Full Name
    sorting nexin 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-051120-45
    See related
    AllianceGenome:ZFIN:ZDB-GENE-051120-45
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:123293
    Summary
    Predicted to enable phosphatidylinositol binding activity. Predicted to act upstream of or within intracellular protein transport. Predicted to be located in early endosome membrane and lamellipodium. Predicted to be part of retromer complex. Orthologous to human SNX2 (sorting nexin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Annotation category: suggests misassembly
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
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    Genomic context

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    See snx2 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (144091..175648)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (293270..324827)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene lysyl oxidase Neighboring gene synuclein, alpha interacting protein Neighboring gene solute carrier family 12 member 2-like Neighboring gene zinc finger protein 608

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Snx5, as a Mind bomb-binding protein, is expressed in hematopoietic and endothelial precursor cells in zebrafish. Yoo KW, et al. FEBS Lett, 2006 Aug 7. PMID 16857196
    2. An antiapoptotic role of sorting nexin 7 is required for liver development in zebrafish. Xu L, et al. Hepatology, 2012 Jun. PMID 22213104
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC123293

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in early endosome to Golgi transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of retromer complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sorting nexin-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037698.1 → NP_001032787.1  sorting nexin-2

      See identical proteins and their annotated locations for NP_001032787.1

      Status: PROVISIONAL

      Source sequence(s)
      BC109441
      UniProtKB/TrEMBL
      Q32LT0
      Conserved Domains (3) summary
      cd07282
      Location:129 → 252
      PX_SNX2; The phosphoinositide binding Phox Homology domain of Sorting Nexin 2
      cd07664
      Location:270 → 503
      BAR_SNX2; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 2
      pfam03700
      Location:33 → 101
      Sorting_nexin; Sorting nexin, N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      144091..175648
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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