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    pgm1 phosphoglucomutase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 394000, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pgm1provided by ZNC
    Official Full Name
    phosphoglucomutase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1245
    See related
    Ensembl:ENSDARG00000013561 AllianceGenome:ZFIN:ZDB-GENE-040426-1245
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:63718
    Summary
    Predicted to enable phosphoglucomutase activity. Predicted to be involved in carbohydrate metabolic process. Predicted to be active in cytosol. Is expressed in central nervous system; digestive system; myotome; notochord; and yolk syncytial layer. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation It; endometrial cancer; and teratoma. Orthologous to human PGM1 (phosphoglucomutase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See pgm1 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (32010183..32025200, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (32023269..32038286, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene cache domain containing 1 Neighboring gene receptor tyrosine kinase-like orphan receptor 1 Neighboring gene EF-hand calcium binding domain 7 Neighboring gene integrin subunit beta 3 binding protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The evolutionary fate of alternatively spliced homologous exons after gene duplication. Abascal F, et al. Genome Biol Evol, 2015 Apr 29. PMID 25931610, Free PMC Article
    2. The toxic effect of triclosan and methyl-triclosan on biological pathways revealed by metabolomics and gene expression in zebrafish embryos. Fu J, et al. Ecotoxicol Environ Saf, 2020 Feb. PMID 31830605
    3. Scrambled eggs: Proteomic portraits and novel biomarkers of egg quality in zebrafish (Danio rerio). Yilmaz O, et al. PLoS One, 2017. PMID 29145436, Free PMC Article
    4. Proteomic analysis of zebrafish (Danio rerio) infected with infectious spleen and kidney necrosis virus. Xiong XP, et al. Dev Comp Immunol, 2011 Apr. PMID 21075138
    5. Proteomic analysis of anatoxin-a acute toxicity in zebrafish reveals gender specific responses and additional mechanisms of cell stress. Carneiro M, et al. Ecotoxicol Environ Saf, 2015 Oct. PMID 26046835

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC63718

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables intramolecular phosphotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoglucomutase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoglucomutase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phosphoglucomutase-1
    NP_957319.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201025.1 → NP_957319.1  phosphoglucomutase-1

      See identical proteins and their annotated locations for NP_957319.1

      Status: PROVISIONAL

      Source sequence(s)
      BC055219
      UniProtKB/TrEMBL
      Q7SXW7
      Related
      ENSDARP00000006510.7, ENSDART00000006417.8
      Conserved Domains (2) summary
      cd03085
      Location:5 → 561
      PGM1; Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction, ...
      PLN02307
      Location:1 → 561
      PLN02307; phosphoglucomutase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      32010183..32025200 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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