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    FYN FYN proto-oncogene, Src family tyrosine kinase [ Homo sapiens (human) ]

    Gene ID: 2534, updated on 27-Dec-2024

    Summary

    Official Symbol
    FYNprovided by HGNC
    Official Full Name
    FYN proto-oncogene, Src family tyrosine kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:4037
    See related
    Ensembl:ENSG00000010810 MIM:137025; AllianceGenome:HGNC:4037
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SLK; SYN; p59-FYN
    Summary
    This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in brain (RPKM 36.8), lymph node (RPKM 29.8) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See FYN in Genome Data Viewer
    Location:
    6q21
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (111660332..111873452, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (112843350..113056537, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (111981535..112194655, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene TRAF3IP2 antisense RNA 1 Neighboring gene VISTA enhancer hs1690 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:111880567-111881066 Neighboring gene MPRA-validated peak6037 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:111885602-111886274 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:111886439-111887638 Neighboring gene TRAF3 interacting protein 2 Neighboring gene TRAF3IP2 eExon liver enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24949 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24950 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:111928045-111928677 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:111941387-111941922 Neighboring gene MPRA-validated peak6038 silencer Neighboring gene uncharacterized LOC105377944 Neighboring gene Sharpr-MPRA regulatory region 7524 Neighboring gene small nucleolar RNA U13 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:111982565-111983248 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:111983249-111983930 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:111983931-111984612 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:111998453-111999376 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:112003973-112004474 Neighboring gene uncharacterized LOC105377945 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24951 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:112051720-112052606 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:112052607-112053491 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24952 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:112072171-112072743 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:112085712-112086288 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17480 Neighboring gene Sharpr-MPRA regulatory region 12906 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24953 Neighboring gene Sharpr-MPRA regulatory region 9187 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24954 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24955 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24956 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24957 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17481 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:112194227-112194726 Neighboring gene uncharacterized LOC102724646 Neighboring gene NANOG hESC enhancer GRCh37_chr6:112205254-112205757 Neighboring gene NANOG hESC enhancer GRCh37_chr6:112210097-112211042 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:112229311-112229997 Neighboring gene long intergenic non-protein coding RNA 2527 Neighboring gene uncharacterized LOC105377947

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (13 hits/1300 screens)

    EBI GWAS Catalog

    Description
    Genome-wide association study of proneness to anger.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tyrosine kinase Fyn-mediated phosphorylation of IFITM3 at position Y20 induces localization of IFITM3 at the endocytic compartments, which impairs inhibition of Env-mediated entry by IFITM3 delta(1-21) mutant PubMed
    env Interaction of HIV-1 gp120 with CD4 leads to increased levels of phosphorylation of the src-family Lck and Fyn protein tyrosine kinases and enhancement of their activities PubMed
    Envelope surface glycoprotein gp160, precursor env Pretreatment of cells with HIV-1 gp160 results in marked inhibition of tyrosine phosphorylation of p59(fyn), PLC-gamma1, ras activation, and TNF-alpha secretion in anti-CD3 mAb activated CD4+ T cells PubMed
    Envelope transmembrane glycoprotein gp41 env HIV-1 gp120 and gp41-induced cell killing is accompanied by tyrosine phosphorylation and activation of the CD4-associated p56(Lck) kinase, and by activation of a second member of the scr family of protein tyrosine kinases, p59(fyn) kinase PubMed
    Nef nef HIV-1 Nef binds to the SH3 domain of Fyn through its proline-rich (PXXP) motifs between amino acid residues 65 and 82; this binding enhances viral replication but not down-regulation of CD4 PubMed
    nef The single amino acid residue number 96 in the SH3 domain of Fyn regulates its affinity and specificity in binding to HIV-1 Nef PubMed
    nef Crystal structure studies reveal the conserved PXXP sequence motif of HIV-1 Nef is part of a polyproline type II helix that is required for Nef binding to the SH3 domain of Fyn PubMed
    Pr55(Gag) gag Fyn enhances HIV-1 Gag assembly and release in T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC45350

    Gene Ontology Provided by GOA

    Items 1 - 25 of 30
    Function Evidence Code Pubs
    enables ATP binding  
    enables G protein-coupled receptor binding PubMed 
    enables alpha-tubulin binding  
    enables disordered domain specific binding PubMed 
    enables enzyme binding PubMed 
    enables ephrin receptor binding PubMed 
    enables growth factor receptor binding PubMed 
    enables histone H2AXY142 kinase activity  
    enables histone H3Y41 kinase activity  
    enables identical protein binding PubMed 
    enables metal ion binding  
    enables non-membrane spanning protein tyrosine kinase activity  
    enables non-membrane spanning protein tyrosine kinase activity PubMed 
    enables non-membrane spanning protein tyrosine kinase activity PubMed 
    enables phospholipase activator activity PubMed 
    enables phospholipase binding PubMed 
    enables protein binding PubMed 
    enables protein tyrosine kinase activity PubMed 
    enables protein tyrosine kinase activity PubMed 
    enables protein tyrosine kinase activity PubMed 
    enables protein tyrosine kinase activity PubMed 
    enables protein tyrosine kinase activity PubMed 
    enables scaffold protein binding PubMed 
    enables signaling receptor binding  
    enables tau protein binding  
    enables tau protein binding PubMed 
    enables tau protein binding PubMed 
    enables tau-protein kinase activity PubMed 
    enables transmembrane transporter binding  
    enables type 5 metabotropic glutamate receptor binding  
    Items 1 - 25 of 30
    Items 1 - 25 of 59
    Process Evidence Code Pubs
    involved_in Fc-gamma receptor signaling pathway involved in phagocytosis  
    involved_in G protein-coupled glutamate receptor signaling pathway PubMed 
    involved_in T cell costimulation  
    involved_in T cell receptor signaling pathway  
    involved_in T cell receptor signaling pathway PubMed 
    involved_in activated T cell proliferation  
    involved_in adaptive immune response  
    involved_in axon guidance  
    involved_in calcium ion transport PubMed 
    involved_in cell differentiation  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway  
    involved_in cellular response to L-glutamate PubMed 
    involved_in cellular response to amyloid-beta PubMed 
    involved_in cellular response to glycine PubMed 
    involved_in cellular response to hydrogen peroxide PubMed 
    involved_in cellular response to platelet-derived growth factor stimulus  
    involved_in cellular response to transforming growth factor beta stimulus  
    involved_in chromatin remodeling  
    involved_in dendrite morphogenesis  
    involved_in dendritic spine maintenance PubMed 
    involved_in detection of mechanical stimulus involved in sensory perception of pain  
    involved_in ephrin receptor signaling pathway  
    involved_in feeding behavior PubMed 
    involved_in forebrain development  
    involved_in gene expression  
    involved_in heart process PubMed 
    involved_in intracellular signal transduction PubMed 
    involved_in learning PubMed 
    involved_in leukocyte migration  
    involved_in modulation of chemical synaptic transmission  
    involved_in natural killer cell activation PubMed 
    involved_in negative regulation of angiogenesis  
    involved_in negative regulation of dendritic spine maintenance  
    involved_in negative regulation of gene expression  
    involved_in negative regulation of hydrogen peroxide biosynthetic process PubMed 
    involved_in negative regulation of inflammatory response to antigenic stimulus  
    involved_in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway PubMed 
    involved_in negative regulation of protein catabolic process  
    involved_in negative regulation of protein ubiquitination  
    involved_in neuron migration  
    involved_in peptidyl-tyrosine phosphorylation PubMed 
    involved_in peptidyl-tyrosine phosphorylation PubMed 
    involved_in positive regulation of neuron projection development  
    involved_in positive regulation of protein localization to membrane PubMed 
    involved_in positive regulation of protein localization to nucleus  
    involved_in positive regulation of protein targeting to membrane  
    involved_in protein catabolic process  
    involved_in protein phosphorylation PubMed 
    involved_in protein ubiquitination  
    involved_in reelin-mediated signaling pathway  
    involved_in regulation of calcium ion import across plasma membrane  
    involved_in regulation of cell shape  
    involved_in regulation of glutamate receptor signaling pathway  
    involved_in regulation of peptidyl-tyrosine phosphorylation  
    involved_in response to amyloid-beta  
    involved_in response to ethanol  
    involved_in response to singlet oxygen PubMed 
    involved_in stimulatory C-type lectin receptor signaling pathway  
    involved_in vascular endothelial growth factor receptor signaling pathway  
    Items 1 - 25 of 59
    Items 1 - 20 of 23
    Component Evidence Code Pubs
    located_in Schaffer collateral - CA1 synapse  
    located_in actin filament  
    located_in cell body  
    located_in cytosol  
    located_in cytosol  
    is_active_in dendrite PubMed 
    located_in dendrite  
    located_in endosome PubMed 
    located_in glial cell projection  
    colocalizes_with membrane raft PubMed 
    is_active_in membrane raft PubMed 
    located_in membrane raft PubMed 
    located_in membrane raft  
    located_in membrane raft PubMed 
    located_in mitochondrion PubMed 
    located_in nucleus PubMed 
    located_in perikaryon  
    located_in perinuclear endoplasmic reticulum PubMed 
    located_in perinuclear region of cytoplasm PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in postsynaptic density  
    Items 1 - 20 of 23

    General protein information

    Preferred Names
    tyrosine-protein kinase Fyn
    Names
    FYN oncogene related to SRC, FGR, YES
    OKT3-induced calcium influx regulator
    c-syn protooncogene
    proto-oncogene Syn
    proto-oncogene c-Fyn
    src-like kinase
    src/yes-related novel
    tyrosine kinase p59fyn(T)
    NP_001357458.1
    NP_002028.1
    NP_694592.1
    NP_694593.1
    XP_005266949.1
    XP_016866139.1
    XP_016866140.1
    XP_016866141.1
    XP_016866142.1
    XP_047274517.1
    XP_047274518.1
    XP_047274519.1
    XP_047274521.1
    XP_047274522.1
    XP_047274523.1
    XP_047274524.1
    XP_047274525.1
    XP_047274526.1
    XP_047274527.1
    XP_047274528.1
    XP_047274529.1
    XP_054210977.1
    XP_054210978.1
    XP_054210979.1
    XP_054210980.1
    XP_054210981.1
    XP_054210982.1
    XP_054210983.1
    XP_054210984.1
    XP_054210985.1
    XP_054210986.1
    XP_054210987.1
    XP_054210988.1
    XP_054210989.1
    XP_054210990.1
    XP_054210991.1
    XP_054210992.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001370529.1NP_001357458.1  tyrosine-protein kinase Fyn isoform a

      Status: REVIEWED

      Source sequence(s)
      AL109916, Z97989
      Consensus CDS
      CCDS5094.1
      UniProtKB/Swiss-Prot
      B5BU57, E1P557, H0UI48, P06241, Q16248, Q5R3A6, Q5R3A7, Q8N5D7
      UniProtKB/TrEMBL
      B3KPS6
      Conserved Domains (3) summary
      cd10418
      Location:145245
      SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
      cd12006
      Location:85140
      SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
      cd05070
      Location:261534
      PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
    2. NM_002037.5NP_002028.1  tyrosine-protein kinase Fyn isoform a

      See identical proteins and their annotated locations for NP_002028.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      BP391373, DA570412, M14333, Z97989
      Consensus CDS
      CCDS5094.1
      UniProtKB/Swiss-Prot
      B5BU57, E1P557, H0UI48, P06241, Q16248, Q5R3A6, Q5R3A7, Q8N5D7
      UniProtKB/TrEMBL
      B3KPS6
      Related
      ENSP00000346671.3, ENST00000354650.7
      Conserved Domains (3) summary
      cd10418
      Location:145245
      SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
      cd12006
      Location:85140
      SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
      cd05070
      Location:261534
      PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
    3. NM_153047.4NP_694592.1  tyrosine-protein kinase Fyn isoform b

      See identical proteins and their annotated locations for NP_694592.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, and lacks an alternate in-frame exon but includes a different in-frame exon in the central coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
      Source sequence(s)
      AL109916, AL158035, Z97989
      Consensus CDS
      CCDS5095.1
      UniProtKB/TrEMBL
      B3KPS6
      Related
      ENSP00000357671.3, ENST00000368682.8
      Conserved Domains (3) summary
      cd10368
      Location:145245
      SH2_Src_Fyn; Src homology 2 (SH2) domain found in Fyn
      cd12006
      Location:85140
      SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
      cd05070
      Location:258531
      PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
    4. NM_153048.4NP_694593.1  tyrosine-protein kinase Fyn isoform c

      See identical proteins and their annotated locations for NP_694593.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, and lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a.
      Source sequence(s)
      BC032496, BP391373, Z97989
      Consensus CDS
      CCDS5096.1
      UniProtKB/TrEMBL
      B3KPS6
      Related
      ENSP00000229471.4, ENST00000229471.8
      Conserved Domains (3) summary
      cd10368
      Location:145245
      SH2_Src_Fyn; Src homology 2 (SH2) domain found in Fyn
      cd12006
      Location:85140
      SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
      cl21453
      Location:231467
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      111660332..111873452 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047418569.1XP_047274525.1  tyrosine-protein kinase Fyn isoform X2

      UniProtKB/TrEMBL
      B3KPS6
      Related
      ENSP00000357667.4, ENST00000368678.8
    2. XM_047418561.1XP_047274517.1  tyrosine-protein kinase Fyn isoform X1

      UniProtKB/Swiss-Prot
      B5BU57, E1P557, H0UI48, P06241, Q16248, Q5R3A6, Q5R3A7, Q8N5D7
      UniProtKB/TrEMBL
      B3KPS6
    3. XM_005266892.5XP_005266949.1  tyrosine-protein kinase Fyn isoform X3

      See identical proteins and their annotated locations for XP_005266949.1

      UniProtKB/TrEMBL
      B3KPS6
      Conserved Domains (3) summary
      cd10368
      Location:145245
      SH2_Src_Fyn; Src homology 2 (SH2) domain found in Fyn
      cd12006
      Location:85140
      SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
      cl21453
      Location:231467
      PKc_like; Protein Kinases, catalytic domain
    4. XM_047418570.1XP_047274526.1  tyrosine-protein kinase Fyn isoform X2

      UniProtKB/TrEMBL
      B3KPS6
    5. XM_017010651.2XP_016866140.1  tyrosine-protein kinase Fyn isoform X1

      UniProtKB/Swiss-Prot
      B5BU57, E1P557, H0UI48, P06241, Q16248, Q5R3A6, Q5R3A7, Q8N5D7
      UniProtKB/TrEMBL
      B3KPS6
      Conserved Domains (3) summary
      cd10418
      Location:145245
      SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
      cd12006
      Location:85140
      SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
      cd05070
      Location:261534
      PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
    6. XM_047418562.1XP_047274518.1  tyrosine-protein kinase Fyn isoform X1

      UniProtKB/Swiss-Prot
      B5BU57, E1P557, H0UI48, P06241, Q16248, Q5R3A6, Q5R3A7, Q8N5D7
      UniProtKB/TrEMBL
      B3KPS6
    7. XM_047418566.1XP_047274522.1  tyrosine-protein kinase Fyn isoform X1

      UniProtKB/Swiss-Prot
      B5BU57, E1P557, H0UI48, P06241, Q16248, Q5R3A6, Q5R3A7, Q8N5D7
      UniProtKB/TrEMBL
      B3KPS6
    8. XM_047418572.1XP_047274528.1  tyrosine-protein kinase Fyn isoform X3

      UniProtKB/TrEMBL
      B3KPS6
    9. XM_047418568.1XP_047274524.1  tyrosine-protein kinase Fyn isoform X2

      UniProtKB/TrEMBL
      B3KPS6
    10. XM_017010650.2XP_016866139.1  tyrosine-protein kinase Fyn isoform X1

      UniProtKB/Swiss-Prot
      B5BU57, E1P557, H0UI48, P06241, Q16248, Q5R3A6, Q5R3A7, Q8N5D7
      UniProtKB/TrEMBL
      B3KPS6
      Related
      ENSP00000357656.2, ENST00000368667.6
      Conserved Domains (3) summary
      cd10418
      Location:145245
      SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
      cd12006
      Location:85140
      SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
      cd05070
      Location:261534
      PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
    11. XM_017010652.2XP_016866141.1  tyrosine-protein kinase Fyn isoform X1

      UniProtKB/Swiss-Prot
      B5BU57, E1P557, H0UI48, P06241, Q16248, Q5R3A6, Q5R3A7, Q8N5D7
      UniProtKB/TrEMBL
      B3KPS6
      Conserved Domains (3) summary
      cd10418
      Location:145245
      SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
      cd12006
      Location:85140
      SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
      cd05070
      Location:261534
      PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
    12. XM_017010653.2XP_016866142.1  tyrosine-protein kinase Fyn isoform X1

      UniProtKB/Swiss-Prot
      B5BU57, E1P557, H0UI48, P06241, Q16248, Q5R3A6, Q5R3A7, Q8N5D7
      UniProtKB/TrEMBL
      B3KPS6
      Conserved Domains (3) summary
      cd10418
      Location:145245
      SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
      cd12006
      Location:85140
      SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
      cd05070
      Location:261534
      PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
    13. XM_047418571.1XP_047274527.1  tyrosine-protein kinase Fyn isoform X2

      UniProtKB/TrEMBL
      B3KPS6
    14. XM_047418565.1XP_047274521.1  tyrosine-protein kinase Fyn isoform X1

      UniProtKB/Swiss-Prot
      B5BU57, E1P557, H0UI48, P06241, Q16248, Q5R3A6, Q5R3A7, Q8N5D7
      UniProtKB/TrEMBL
      B3KPS6
    15. XM_047418567.1XP_047274523.1  tyrosine-protein kinase Fyn isoform X1

      UniProtKB/Swiss-Prot
      B5BU57, E1P557, H0UI48, P06241, Q16248, Q5R3A6, Q5R3A7, Q8N5D7
      UniProtKB/TrEMBL
      B3KPS6
    16. XM_047418563.1XP_047274519.1  tyrosine-protein kinase Fyn isoform X1

      UniProtKB/Swiss-Prot
      B5BU57, E1P557, H0UI48, P06241, Q16248, Q5R3A6, Q5R3A7, Q8N5D7
      UniProtKB/TrEMBL
      B3KPS6
    17. XM_047418573.1XP_047274529.1  tyrosine-protein kinase Fyn isoform X4

      UniProtKB/TrEMBL
      B3KPS6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      112843350..113056537 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054355012.1XP_054210987.1  tyrosine-protein kinase Fyn isoform X2

      UniProtKB/TrEMBL
      B3KPS6
    2. XM_054355003.1XP_054210978.1  tyrosine-protein kinase Fyn isoform X1

      UniProtKB/Swiss-Prot
      B5BU57, E1P557, H0UI48, P06241, Q16248, Q5R3A6, Q5R3A7, Q8N5D7
      UniProtKB/TrEMBL
      B3KPS6
    3. XM_054355015.1XP_054210990.1  tyrosine-protein kinase Fyn isoform X3

      UniProtKB/TrEMBL
      B3KPS6
    4. XM_054355013.1XP_054210988.1  tyrosine-protein kinase Fyn isoform X2

      UniProtKB/TrEMBL
      B3KPS6
    5. XM_054355006.1XP_054210981.1  tyrosine-protein kinase Fyn isoform X1

      UniProtKB/Swiss-Prot
      B5BU57, E1P557, H0UI48, P06241, Q16248, Q5R3A6, Q5R3A7, Q8N5D7
      UniProtKB/TrEMBL
      B3KPS6
    6. XM_054355004.1XP_054210979.1  tyrosine-protein kinase Fyn isoform X1

      UniProtKB/Swiss-Prot
      B5BU57, E1P557, H0UI48, P06241, Q16248, Q5R3A6, Q5R3A7, Q8N5D7
      UniProtKB/TrEMBL
      B3KPS6
    7. XM_054355010.1XP_054210985.1  tyrosine-protein kinase Fyn isoform X1

      UniProtKB/Swiss-Prot
      B5BU57, E1P557, H0UI48, P06241, Q16248, Q5R3A6, Q5R3A7, Q8N5D7
      UniProtKB/TrEMBL
      B3KPS6
    8. XM_054355002.1XP_054210977.1  tyrosine-protein kinase Fyn isoform X1

      UniProtKB/Swiss-Prot
      B5BU57, E1P557, H0UI48, P06241, Q16248, Q5R3A6, Q5R3A7, Q8N5D7
      UniProtKB/TrEMBL
      B3KPS6
    9. XM_054355016.1XP_054210991.1  tyrosine-protein kinase Fyn isoform X3

      UniProtKB/TrEMBL
      B3KPS6
    10. XM_054355011.1XP_054210986.1  tyrosine-protein kinase Fyn isoform X2

      UniProtKB/TrEMBL
      B3KPS6
    11. XM_054355007.1XP_054210982.1  tyrosine-protein kinase Fyn isoform X1

      UniProtKB/Swiss-Prot
      B5BU57, E1P557, H0UI48, P06241, Q16248, Q5R3A6, Q5R3A7, Q8N5D7
      UniProtKB/TrEMBL
      B3KPS6
    12. XM_054355009.1XP_054210984.1  tyrosine-protein kinase Fyn isoform X1

      UniProtKB/Swiss-Prot
      B5BU57, E1P557, H0UI48, P06241, Q16248, Q5R3A6, Q5R3A7, Q8N5D7
      UniProtKB/TrEMBL
      B3KPS6
    13. XM_054355005.1XP_054210980.1  tyrosine-protein kinase Fyn isoform X1

      UniProtKB/Swiss-Prot
      B5BU57, E1P557, H0UI48, P06241, Q16248, Q5R3A6, Q5R3A7, Q8N5D7
      UniProtKB/TrEMBL
      B3KPS6
    14. XM_054355008.1XP_054210983.1  tyrosine-protein kinase Fyn isoform X1

      UniProtKB/Swiss-Prot
      B5BU57, E1P557, H0UI48, P06241, Q16248, Q5R3A6, Q5R3A7, Q8N5D7
      UniProtKB/TrEMBL
      B3KPS6
    15. XM_054355014.1XP_054210989.1  tyrosine-protein kinase Fyn isoform X2

      UniProtKB/TrEMBL
      B3KPS6
    16. XM_054355017.1XP_054210992.1  tyrosine-protein kinase Fyn isoform X4

      UniProtKB/TrEMBL
      B3KPS6

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