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    Dido1 death inducer-obliterator 1 [ Mus musculus (house mouse) ]

    Gene ID: 23856, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Dido1provided by MGI
    Official Full Name
    death inducer-obliterator 1provided by MGI
    Primary source
    MGI:MGI:1344352
    See related
    Ensembl:ENSMUSG00000038914 AllianceGenome:MGI:1344352
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    dido; DIO-1; Datf1; DATF-1; 6720461J16Rik; C130092D22Rik; D130048F08Rik
    Summary
    This gene encodes a transcription factor involved in apoptosis. The encoded protein functions in cell cycle progression and plays a role in chromosomal stability. This protein regulates the self-renewal of embryonic stem cells. Disruption of this gene in mice causes symptoms similar to myelodysplastic/myeloproliferative diseases in humans. Mice lacking this gene show severely reduced fertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 4.5), thymus adult (RPKM 4.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dido1 in Genome Data Viewer
    Location:
    2; 2 H4
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (180299757..180351886, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (180657963..180710068, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene opioid growth factor receptor Neighboring gene collagen, type IX, alpha 3 Neighboring gene transcription factor-like 5 (basic helix-loop-helix) Neighboring gene predicted gene, 54097 Neighboring gene STARR-positive B cell enhancer mm9_chr2:180436639-180436940 Neighboring gene STARR-seq mESC enhancer starr_06736 Neighboring gene predicted gene, 22502 Neighboring gene STARR-positive B cell enhancer ABC_E9213 Neighboring gene GID complex subunit 8 Neighboring gene predicted gene, 30455 Neighboring gene solute carrier family 17, member 9 Neighboring gene STARR-seq mESC enhancer starr_06739 Neighboring gene STARR-positive B cell enhancer ABC_E1614 Neighboring gene basic helix-loop-helix family, member e23

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. DIDO is necessary for the adipogenesis that promotes diet-induced obesity. García-López MÁ, et al. Proc Natl Acad Sci U S A, 2024 Jan 16. PMID 38194457, Free PMC Article
    2. Impaired stem cell differentiation and somatic cell reprogramming in DIDO3 mutants with altered RNA processing and increased R-loop levels. Fütterer A, et al. Cell Death Dis, 2021 Jun 21. PMID 34155199, Free PMC Article
    3. Synaptonemal complex assembly and H3K4Me3 demethylation determine DIDO3 localization in meiosis. Prieto I, et al. Chromosoma, 2009 Oct. PMID 19557426
    4. Chronic stress and impaired glutamate function elicit a depressive-like phenotype and common changes in gene expression in the mouse frontal cortex. Tordera RM, et al. Eur Neuropsychopharmacol, 2011 Jan. PMID 20937555
    5. Dido3 PHD modulates cell differentiation and division. Gatchalian J, et al. Cell Rep, 2013 Jul 11. PMID 23831028, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PARP1, DIDO3, and DHX9 Proteins Mutually Interact in Mouse Fibroblasts, with Effects on DNA Replication Dynamics, Senescence, and Oncogenic Transformation.
      Title: PARP1, DIDO3, and DHX9 Proteins Mutually Interact in Mouse Fibroblasts, with Effects on DNA Replication Dynamics, Senescence, and Oncogenic Transformation.
    2. DIDO is necessary for the adipogenesis that promotes diet-induced obesity.
      Title: DIDO is necessary for the adipogenesis that promotes diet-induced obesity.
    3. Impaired stem cell differentiation and somatic cell reprogramming in DIDO3 mutants with altered RNA processing and increased R-loop levels.
      Title: Impaired stem cell differentiation and somatic cell reprogramming in DIDO3 mutants with altered RNA processing and increased R-loop levels.
    4. Embryonic stem cells mainly express DIDO3 and their differentiation after leukemia inhibitory factor withdrawal requires DIDO1 expression. DIDO3 regulates DIDO1 expression.
      Title: DIDO as a Switchboard that Regulates Self-Renewal and Differentiation in Embryonic Stem Cells.
    5. Death inducer obliterator (Dido3)-dependent targeting of histone deacetylase 6 (HDAC6) is a key determinant of cilium size in growth-arrested cells
      Title: Dido3-dependent HDAC6 targeting controls cilium size.
    6. Data indicate that death inducer-obliterator (dido) mutant mice with high incidence of perinatal lethality and distinct neurodevelopmental, morphogenetic, and metabolic alterations.
      Title: Dido mutations trigger perinatal death and generate brain abnormalities and behavioral alterations in surviving adult mice.
    7. Dido1 is able to regulate self-renewal of mouse embryonic stem cells.
      Title: The death-inducer obliterator 1 (Dido1) gene regulates embryonic stem cell self-renewal.
    8. Dido3 PHD interacts with histone H3K4me3 and regulates expression of stemness genes in embryonic stem cells.
      Title: Dido3 PHD modulates cell differentiation and division.
    9. loss of Dido3 expression compromises differentiation of embryonic stem cells in vitro and of epiblast cells in vivo, resulting in early embryonic death at around day 8.5 of gestation
      Title: Ablation of Dido3 compromises lineage commitment of stem cells in vitro and during early embryonic development.
    10. results indicate that histone H3 lysine 4 demethylation modulates DIDO3 localization in meiosis and suggest epigenetic regulation of the synaptonemal complex
      Title: Synaptonemal complex assembly and H3K4Me3 demethylation determine DIDO3 localization in meiosis.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (4)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • mKIAA0333, C530043I07

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    death-inducer obliterator 1
    Names
    death inducer-obliterator-2
    death inducer-obliterator-3
    death-associated transcription factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291432.2 → NP_001278361.1  death-inducer obliterator 1 isoform Dido1

      Status: REVIEWED

      Source sequence(s)
      AL732560
      Consensus CDS
      CCDS17184.1
      UniProtKB/Swiss-Prot
      Q8C9B9
      Related
      ENSMUSP00000099344.2, ENSMUST00000103055.8
      Conserved Domains (3) summary
      cd15639
      Location:263 → 316
      PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
      pfam01749
      Location:165 → 241
      IBB; Importin beta binding domain
      pfam02724
      Location:122 → 192
      CDC45; CDC45-like protein

    2. NM_001291433.2 → NP_001278362.1  death-inducer obliterator 1 isoform Dido2

      Status: REVIEWED

      Source sequence(s)
      AL732560
      Consensus CDS
      CCDS17183.1
      UniProtKB/Swiss-Prot
      Q8C9B9
      Related
      ENSMUSP00000099345.4, ENSMUST00000103056.10
      Conserved Domains (4) summary
      smart00510
      Location:669 → 770
      TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
      cd15639
      Location:263 → 316
      PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
      pfam01749
      Location:165 → 241
      IBB; Importin beta binding domain
      pfam07744
      Location:1052 → 1158
      SPOC; SPOC domain

    3. NM_011805.4 → NP_035935.2  death-inducer obliterator 1 isoform Dido1

      Status: REVIEWED

      Source sequence(s)
      AL732560
      Consensus CDS
      CCDS17184.1
      UniProtKB/Swiss-Prot
      Q8C9B9
      Related
      ENSMUSP00000119689.2, ENSMUST00000130986.8
      Conserved Domains (3) summary
      cd15639
      Location:263 → 316
      PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
      pfam01749
      Location:165 → 241
      IBB; Importin beta binding domain
      pfam02724
      Location:122 → 192
      CDC45; CDC45-like protein

    4. NM_175551.5 → NP_780760.2  death-inducer obliterator 1 isoform Dido3

      Status: REVIEWED

      Source sequence(s)
      AL732560
      Consensus CDS
      CCDS17182.1
      UniProtKB/Swiss-Prot
      A2AJ47, A2AJ48, B2RS46, Q05C59, Q3ZTP5, Q3ZTP6, Q4V9W1, Q6ZQD7, Q80V34, Q8BMD0, Q8BRG2, Q8C9B9, Q8CHR5, Q9WV00
      Related
      ENSMUSP00000084794.4, ENSMUST00000087517.10
      Conserved Domains (7) summary
      smart00510
      Location:669 → 770
      TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
      PRK14954
      Location:600 → 665
      PRK14954; DNA polymerase III subunits gamma and tau; Provisional
      PHA03247
      Location:1571 → 2083
      PHA03247; large tegument protein UL36; Provisional
      COG5034
      Location:157 → 299
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      TIGR01622
      Location:2142 → 2180
      SF-CC1; splicing factor, CC1-like family
      cd15639
      Location:263 → 316
      PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
      pfam07744
      Location:1045 → 1190
      SPOC; SPOC domain

    5. NM_177852.5 → NP_808520.2  death-inducer obliterator 1 isoform Dido2

      Status: REVIEWED

      Source sequence(s)
      AL732560
      Consensus CDS
      CCDS17183.1
      UniProtKB/Swiss-Prot
      Q8C9B9
      Related
      ENSMUSP00000099346.2, ENSMUST00000103057.8
      Conserved Domains (4) summary
      smart00510
      Location:669 → 770
      TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
      cd15639
      Location:263 → 316
      PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
      pfam01749
      Location:165 → 241
      IBB; Importin beta binding domain
      pfam07744
      Location:1052 → 1158
      SPOC; SPOC domain

    RNA

    1. NR_111965.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an alternate internal exon and contains a 3' terminal exon that extends past a splice site used in variant 3. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 3, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL732560

    2. NR_169212.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL732560

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      180299757..180351886 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500609.5 → XP_006500672.1  death-inducer obliterator 1 isoform X1

      UniProtKB/Swiss-Prot
      A2AJ47, A2AJ48, B2RS46, Q05C59, Q3ZTP5, Q3ZTP6, Q4V9W1, Q6ZQD7, Q80V34, Q8BMD0, Q8BRG2, Q8C9B9, Q8CHR5, Q9WV00
      Conserved Domains (7) summary
      smart00510
      Location:669 → 770
      TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
      PRK14954
      Location:600 → 665
      PRK14954; DNA polymerase III subunits gamma and tau; Provisional
      PHA03247
      Location:1571 → 2083
      PHA03247; large tegument protein UL36; Provisional
      COG5034
      Location:157 → 299
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      TIGR01622
      Location:2142 → 2180
      SF-CC1; splicing factor, CC1-like family
      cd15639
      Location:263 → 316
      PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
      pfam07744
      Location:1045 → 1190
      SPOC; SPOC domain

    2. XM_006500615.5 → XP_006500678.1  death-inducer obliterator 1 isoform X1

      UniProtKB/Swiss-Prot
      A2AJ47, A2AJ48, B2RS46, Q05C59, Q3ZTP5, Q3ZTP6, Q4V9W1, Q6ZQD7, Q80V34, Q8BMD0, Q8BRG2, Q8C9B9, Q8CHR5, Q9WV00
      Conserved Domains (7) summary
      smart00510
      Location:669 → 770
      TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
      PRK14954
      Location:600 → 665
      PRK14954; DNA polymerase III subunits gamma and tau; Provisional
      PHA03247
      Location:1571 → 2083
      PHA03247; large tegument protein UL36; Provisional
      COG5034
      Location:157 → 299
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      TIGR01622
      Location:2142 → 2180
      SF-CC1; splicing factor, CC1-like family
      cd15639
      Location:263 → 316
      PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
      pfam07744
      Location:1045 → 1190
      SPOC; SPOC domain

    3. XM_006500610.5 → XP_006500673.1  death-inducer obliterator 1 isoform X1

      UniProtKB/Swiss-Prot
      A2AJ47, A2AJ48, B2RS46, Q05C59, Q3ZTP5, Q3ZTP6, Q4V9W1, Q6ZQD7, Q80V34, Q8BMD0, Q8BRG2, Q8C9B9, Q8CHR5, Q9WV00
      Conserved Domains (7) summary
      smart00510
      Location:669 → 770
      TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
      PRK14954
      Location:600 → 665
      PRK14954; DNA polymerase III subunits gamma and tau; Provisional
      PHA03247
      Location:1571 → 2083
      PHA03247; large tegument protein UL36; Provisional
      COG5034
      Location:157 → 299
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      TIGR01622
      Location:2142 → 2180
      SF-CC1; splicing factor, CC1-like family
      cd15639
      Location:263 → 316
      PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
      pfam07744
      Location:1045 → 1190
      SPOC; SPOC domain

    4. XM_006500608.5 → XP_006500671.1  death-inducer obliterator 1 isoform X1

      UniProtKB/Swiss-Prot
      A2AJ47, A2AJ48, B2RS46, Q05C59, Q3ZTP5, Q3ZTP6, Q4V9W1, Q6ZQD7, Q80V34, Q8BMD0, Q8BRG2, Q8C9B9, Q8CHR5, Q9WV00
      Conserved Domains (7) summary
      smart00510
      Location:669 → 770
      TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
      PRK14954
      Location:600 → 665
      PRK14954; DNA polymerase III subunits gamma and tau; Provisional
      PHA03247
      Location:1571 → 2083
      PHA03247; large tegument protein UL36; Provisional
      COG5034
      Location:157 → 299
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      TIGR01622
      Location:2142 → 2180
      SF-CC1; splicing factor, CC1-like family
      cd15639
      Location:263 → 316
      PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
      pfam07744
      Location:1045 → 1190
      SPOC; SPOC domain

    5. XM_006500616.4 → XP_006500679.1  death-inducer obliterator 1 isoform X1

      UniProtKB/Swiss-Prot
      A2AJ47, A2AJ48, B2RS46, Q05C59, Q3ZTP5, Q3ZTP6, Q4V9W1, Q6ZQD7, Q80V34, Q8BMD0, Q8BRG2, Q8C9B9, Q8CHR5, Q9WV00
      Conserved Domains (7) summary
      smart00510
      Location:669 → 770
      TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
      PRK14954
      Location:600 → 665
      PRK14954; DNA polymerase III subunits gamma and tau; Provisional
      PHA03247
      Location:1571 → 2083
      PHA03247; large tegument protein UL36; Provisional
      COG5034
      Location:157 → 299
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      TIGR01622
      Location:2142 → 2180
      SF-CC1; splicing factor, CC1-like family
      cd15639
      Location:263 → 316
      PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
      pfam07744
      Location:1045 → 1190
      SPOC; SPOC domain

    6. XM_006500611.5 → XP_006500674.1  death-inducer obliterator 1 isoform X1

      UniProtKB/Swiss-Prot
      A2AJ47, A2AJ48, B2RS46, Q05C59, Q3ZTP5, Q3ZTP6, Q4V9W1, Q6ZQD7, Q80V34, Q8BMD0, Q8BRG2, Q8C9B9, Q8CHR5, Q9WV00
      Conserved Domains (7) summary
      smart00510
      Location:669 → 770
      TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
      PRK14954
      Location:600 → 665
      PRK14954; DNA polymerase III subunits gamma and tau; Provisional
      PHA03247
      Location:1571 → 2083
      PHA03247; large tegument protein UL36; Provisional
      COG5034
      Location:157 → 299
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      TIGR01622
      Location:2142 → 2180
      SF-CC1; splicing factor, CC1-like family
      cd15639
      Location:263 → 316
      PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
      pfam07744
      Location:1045 → 1190
      SPOC; SPOC domain

    7. XM_006500612.4 → XP_006500675.1  death-inducer obliterator 1 isoform X1

      UniProtKB/Swiss-Prot
      A2AJ47, A2AJ48, B2RS46, Q05C59, Q3ZTP5, Q3ZTP6, Q4V9W1, Q6ZQD7, Q80V34, Q8BMD0, Q8BRG2, Q8C9B9, Q8CHR5, Q9WV00
      Conserved Domains (7) summary
      smart00510
      Location:669 → 770
      TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
      PRK14954
      Location:600 → 665
      PRK14954; DNA polymerase III subunits gamma and tau; Provisional
      PHA03247
      Location:1571 → 2083
      PHA03247; large tegument protein UL36; Provisional
      COG5034
      Location:157 → 299
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      TIGR01622
      Location:2142 → 2180
      SF-CC1; splicing factor, CC1-like family
      cd15639
      Location:263 → 316
      PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
      pfam07744
      Location:1045 → 1190
      SPOC; SPOC domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C9B9.4 GenPept UniProtKB/Swiss-Prot:Q8C9B9

    Gene LinkOut

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