PRXL2B peroxiredoxin like 2B [Homo sapiens (human)] - Gene

Summary

Official Symbol: PRXL2Bprovided by HGNC
Official Full Name: peroxiredoxin like 2Bprovided by HGNC
Primary source: HGNC:HGNC:28390
See related: Ensembl:ENSG00000157870 AllianceGenome:HGNC:28390
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: C1orf93; FAM213B
Summary: Predicted to enable prostaglandin F synthase activity. Predicted to be involved in prostaglandin biosynthetic process. Located in extracellular exosome and mitochondrion. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in duodenum (RPKM 15.1), small intestine (RPKM 14.9) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p36.32

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (2586523..2591468)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (2028168..2033113)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (2517962..2522907)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1S3693 (e-PCR)
- UniSTS:474271

G20652 (e-PCR)
- UniSTS:51657

A006A26 (e-PCR)
- UniSTS:51658

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables prostaglandin F synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables prostaglandin F synthase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in prostaglandin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in prostaglandin biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
located_in mitochondrion	HTP more info	PubMed
located_in myelin sheath	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: prostamide/prostaglandin F synthase

Names: family with sequence similarity 213 member B; prostamide/PG F synthase; prostamide/PGF synthase; thioredoxin-type PGF synthase

NP_001182665.4

EC 1.11.1.20

NP_001182666.4

EC 1.11.1.20

NP_001182667.4

EC 1.11.1.20

NP_001182669.4

EC 1.11.1.20

NP_001182670.4

EC 1.11.1.20

NP_689584.5

EC 1.11.1.20

XP_006710417.1

EC 1.11.1.20

XP_011538967.1

EC 1.11.1.20

XP_047301361.1

EC 1.11.1.20

XP_047301362.1

EC 1.11.1.20

XP_054184576.1

EC 1.11.1.20

XP_054184577.1

EC 1.11.1.20

XP_054184578.1

EC 1.11.1.20

XP_054184579.1

EC 1.11.1.20

XP_054190308.1

EC 1.11.1.20

XP_054190309.1

EC 1.11.1.20

XP_054190310.1

EC 1.11.1.20

XP_054190311.1

EC 1.11.1.20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001195736.3 → NP_001182665.4 prostamide/prostaglandin F synthase isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform a).

Source sequence(s)

AK057027, AK075273, BM976058, DC351872

Consensus CDS

CCDS72690.1

UniProtKB/TrEMBL

A0A0A0MT35

Related

ENSP00000413218.3, ENST00000444521.6

Conserved Domains (1) summary

cd02970
Location:18 → 185

PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
NM_001195737.3 → NP_001182666.4 prostamide/prostaglandin F synthase isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses three different splice sites in the coding region, compared to variant 1. The resulting protein (isoform c) is shorter when it is compared to isoform a.

Source sequence(s)

AK075273, AK303504, BM976058, DC351872

UniProtKB/TrEMBL

J3KRV9

Related

ENST00000484099.5

Conserved Domains (1) summary

cd02970
Location:18 → 123

PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
NM_001195738.3 → NP_001182667.4 prostamide/prostaglandin F synthase isoform d

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses two different splice sites in the coding region which changes the reading frame, compared to variant 1. The resulting protein (isoform d) is shorter and has a distinct C-terminus when it is compared to isoform a.

Source sequence(s)

AK075273, BM976058, DC351872

Consensus CDS

CCDS90843.1

UniProtKB/TrEMBL

J3KPF6

Related

ENSP00000367684.2, ENST00000378427.6

Conserved Domains (1) summary

cd02970
Location:18 → 154

PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
NM_001195740.3 → NP_001182669.4 prostamide/prostaglandin F synthase isoform e

Status: VALIDATED

Description

Transcript Variant: This variant (5) uses two different splice sites and lacks an alternate exon in the coding region, compared to variant 1. The resulting protein (isoform e) is shorter when it is compared to isoform a.

Source sequence(s)

AK075273, AK316243, BM976058, DC351872

Consensus CDS

CCDS72691.1

UniProtKB/TrEMBL

A0A0A0MRV4

Related

ENSP00000367682.6, ENST00000378425.9

Conserved Domains (1) summary

cd02970
Location:18 → 123

PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
NM_001195741.3 → NP_001182670.4 prostamide/prostaglandin F synthase isoform f

Status: VALIDATED

Description

Transcript Variant: This variant (6) uses two different splice sites and lacks an alternate exon in the coding region, compared to variant 1. The resulting protein (isoform f) is shorter when it is compared to isoform a.

Source sequence(s)

AK075273, AK298926, BM976058, DC351872

Consensus CDS

CCDS55564.2

UniProtKB/TrEMBL

A0A2P0CTH9, A0A2P0CU24

Related

ENSP00000443605.2, ENST00000537325.6

Conserved Domains (1) summary

cd02970
Location:18 → 123

PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
NM_152371.5 → NP_689584.5 prostamide/prostaglandin F synthase isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses a different splice site in an internal coding region exon, compared to variant 1. The resulting protein (isoform b) is shorter when it is compared to isoform a.

Source sequence(s)

AF425266, AK075273, BC022547, BM976058, DC351872

Consensus CDS

CCDS44.3

UniProtKB/Swiss-Prot

A8K793, B3KPY3, B4DQR9, B4E0S5, B7ZAC8, B9DI90, B9DI92, J3KQD0, Q8N2H0, Q8TBF2

UniProtKB/TrEMBL

A0A2P0CTB1

Related

ENSP00000394405.4, ENST00000419916.8

Conserved Domains (1) summary

cd02970
Location:18 → 167

PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

RNA

NR_036637.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (7) uses an alternate 5'-most exon and an alternate internal splice site, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.

Source sequence(s)

AK075273, BM976058, BQ709693, DA495138
NR_036638.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (8) uses an alternate 5'-most exon and two alternate internal splice sites, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.

Source sequence(s)

AK075273, BI908668, BM976058, DA292832

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

2586523..2591468

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047445405.1 → XP_047301361.1 prostamide/prostaglandin F synthase isoform X1
XM_011540665.2 → XP_011538967.1 prostamide/prostaglandin F synthase isoform X3

See identical proteins and their annotated locations for XP_011538967.1

UniProtKB/TrEMBL

A0A0A0MT35

Conserved Domains (1) summary

cd02970
Location:48 → 140

PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
XM_047445406.1 → XP_047301362.1 prostamide/prostaglandin F synthase isoform X4

UniProtKB/TrEMBL

J3KPF5

Related

ENSP00000367681.5, ENST00000378424.9
XM_006710354.4 → XP_006710417.1 prostamide/prostaglandin F synthase isoform X2

See identical proteins and their annotated locations for XP_006710417.1

Conserved Domains (1) summary

cd02970
Location:48 → 153

PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

NT_187515.1 Reference GRCh38.p14 ALT_REF_LOCI_1

Range

137713..142658

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054328601.1 → XP_054184576.1 prostamide/prostaglandin F synthase isoform X1
XM_054328603.1 → XP_054184578.1 prostamide/prostaglandin F synthase isoform X3
XM_054328604.1 → XP_054184579.1 prostamide/prostaglandin F synthase isoform X4

UniProtKB/TrEMBL

J3KPF5
XM_054328602.1 → XP_054184577.1 prostamide/prostaglandin F synthase isoform X2

Alternate T2T-CHM13v2.0

Genomic

NC_060925.1 Alternate T2T-CHM13v2.0

Range

2028168..2033113

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054334333.1 → XP_054190308.1 prostamide/prostaglandin F synthase isoform X1
XM_054334335.1 → XP_054190310.1 prostamide/prostaglandin F synthase isoform X3
XM_054334336.1 → XP_054190311.1 prostamide/prostaglandin F synthase isoform X4

UniProtKB/TrEMBL

J3KPF5
XM_054334334.1 → XP_054190309.1 prostamide/prostaglandin F synthase isoform X2