TEN1 TEN1 subunit of CST complex [Homo sapiens (human)] - Gene

Summary

Official Symbol: TEN1provided by HGNC
Official Full Name: TEN1 subunit of CST complexprovided by HGNC
Primary source: HGNC:HGNC:37242
See related: Ensembl:ENSG00000257949 MIM:613130; AllianceGenome:HGNC:37242
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: C17orf106
Summary: C17ORF106, or TEN1, appears to function in a telomere-associated complex with STN1 (OBFC1; MIM 613128) and CTC1 (C17ORF68; MIM 613129) (Miyake et al., 2009 [PubMed 19854130]).[supplied by OMIM, Nov 2009]
Expression: Ubiquitous expression in small intestine (RPKM 13.6), fat (RPKM 12.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17q25.1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (75979240..76000586)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (76872369..76893714)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (73975321..73996667)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CST-polymerase alpha-primase solves a second telomere end-replication problem.
Title: CST-polymerase α-primase solves a second telomere end-replication problem.
Reconstitution of a telomeric replicon organized by CST.
Title: Reconstitution of a telomeric replicon organized by CST.
Structures of the human CST-Polalpha-primase complex bound to telomere templates.
Title: Structures of the human CST-Polα-primase complex bound to telomere templates.
Pan-cancer analysis reveals that CTC1-STN1-TEN1 (CST) complex may have a key position in oncology.
Title: Pan-cancer analysis reveals that CTC1-STN1-TEN1 (CST) complex may have a key position in oncology.
CST in maintaining genome stability: Beyond telomeres.
Title: CST in maintaining genome stability: Beyond telomeres.
An Indian child with Coats plus syndrome due to mutations in STN1.
Title: An Indian child with Coats plus syndrome due to mutations in STN1.
Human CST complex protects stalled replication forks by directly blocking MRE11 degradation of nascent-strand DNA.
Title: Human CST complex protects stalled replication forks by directly blocking MRE11 degradation of nascent-strand DNA.
This work provides a blueprint to pinpoint the possible consequences of pathogenic mutations in the CST complex subunit TEN1.
Title: Structural and functional impact of non-synonymous SNPs in the CST complex subunit TEN1: structural genomics approach.
CST functions in two distinct aspects of genome-wide DNA replication, namely, origin licensing and replisome assembly. CST interacts with additional replisome components, MCM and AND-1.
Title: Human CST suppresses origin licensing and promotes AND-1/Ctf4 chromatin association.
The CST complex (CTC1-STN1-TEN1) maintains genome integrity through resolution of G4 structures both ahead of the replication fork and on the lagging strand template
Title: Mammalian CST averts replication failure by preventing G-quadruplex accumulation.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Readthrough TEN1-CDK3

Readthrough gene: TEN1-CDK3, Included gene: CDK3

Clone Names

FLJ39785, MGC54300, DKFZp686C0493, DKFZp686G1463

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables single-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables telomerase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables telomeric DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables telomeric DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of telomere maintenance via telomerase	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of telomere maintenance via telomerase	IDA Inferred from Direct Assay more info	PubMed
involved_in telomere capping	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of CST complex	IBA Inferred from Biological aspect of Ancestor more info
part_of CST complex	IDA Inferred from Direct Assay more info	PubMed
part_of CST complex	ISS Inferred from Sequence or Structural Similarity more info
located_in chromosome, telomeric region	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: CST complex subunit TEN1

Names: TEN1 telomerase capping complex subunit homolog; TEN1, CST complex subunit; protein telomeric pathways with STN1 homolog; telomere length regulation protein TEN1 homolog; telomeric pathways in association with Stn1, number 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.