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    JPT1 Jupiter microtubule associated homolog 1 [ Homo sapiens (human) ]

    Gene ID: 51155, updated on 27-Nov-2024

    Summary

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    Official Symbol
    JPT1provided by HGNC
    Official Full Name
    Jupiter microtubule associated homolog 1provided by HGNC
    Primary source
    HGNC:HGNC:14569
    See related
    Ensembl:ENSG00000189159 MIM:619242; AllianceGenome:HGNC:14569
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HN1; ARM2; HN1A
    Summary
    Located in cytosol; intercellular bridge; and microtubule cytoskeleton. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis (RPKM 36.4), colon (RPKM 19.4) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See JPT1 in Genome Data Viewer
    Location:
    17q25.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (75135243..75154512, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (76026703..76045989, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (73131338..73150607, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8954 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73089299-73089872 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73089873-73090445 Neighboring gene solute carrier family 16 member 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73100784-73101284 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73101285-73101785 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8955 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73110035-73110574 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12734 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12735 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:73120068-73121267 Neighboring gene armadillo repeat containing 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12736 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:73126856-73127060 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8956 Neighboring gene uncharacterized LOC107985034 Neighboring gene 5', 3'-nucleotidase, cytosolic Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:73143638-73144837 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8957 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73151095-73151690 Neighboring gene small ubiquitin like modifier 2 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73178362-73179012 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8959 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:73200579-73201513 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:73201514-73202447 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73203873-73204440 Neighboring gene nucleoporin 85 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73220785-73221286 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:73221550-73222749 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:73230746-73230909

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Role of hematological and neurological expressed 1 (HN1) in human cancers. Li H, et al. Crit Rev Oncol Hematol, 2024 Sep. PMID 38992849
    2. Ubiquitously expressed hematological and neurological expressed 1 downregulates Akt-mediated GSK3β signaling, and its knockdown results in deregulated G2/M transition in prostate cells. Varisli L, et al. DNA Cell Biol, 2011 Jun. PMID 21323578
    3. HN1 negatively influences the β-catenin/E-cadherin interaction, and contributes to migration in prostate cells. Varisli L, et al. J Cell Biochem, 2015 Jan. PMID 25169422
    4. Jupiter microtubule-associated homolog 1 (JPT1): A predictive and pharmacodynamic biomarker of metformin response in endometrial cancers. Bateman NW, et al. Cancer Med, 2020 Feb. PMID 31808620, Free PMC Article
    5. HN1 as a diagnostic and prognostic biomarker for liver cancer. Liu Z, et al. Biosci Rep, 2020 Jul 31. PMID 32700728, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Role of hematological and neurological expressed 1 (HN1) in human cancers.
      Title: Role of hematological and neurological expressed 1 (HN1) in human cancers.
    2. Hematological and neurological expressed 1 (HN1) activates c-Myc signaling by inhibiting ubiquitin-mediated proteasomal degradation of c-Myc in hepatocellular carcinoma.
      Title: Hematological and neurological expressed 1 (HN1) activates c-Myc signaling by inhibiting ubiquitin-mediated proteasomal degradation of c-Myc in hepatocellular carcinoma.
    3. Thirdhand Smoke May Promote Lung Adenocarcinoma Development through HN1.
      Title: Thirdhand Smoke May Promote Lung Adenocarcinoma Development through HN1.
    4. LncRNA HOXA11-AS promotes cell growth by sponging miR-24-3p to regulate JPT1 in prostate cancer.
      Title: LncRNA HOXA11-AS promotes cell growth by sponging miR-24-3p to regulate JPT1 in prostate cancer.
    5. Jupiter microtubule-associated homolog 1 (JPT1): A predictive and pharmacodynamic biomarker of metformin response in endometrial cancers.
      Title: Jupiter microtubule-associated homolog 1 (JPT1): A predictive and pharmacodynamic biomarker of metformin response in endometrial cancers.
    6. HN1 as a diagnostic and prognostic biomarker for liver cancer.
      Title: HN1 as a diagnostic and prognostic biomarker for liver cancer.
    7. HN1 promotes tumor associated lymphangiogenesis and lymph node metastasis via NF-kappaB signaling activation in cervical carcinoma.
      Title: HN1 promotes tumor associated lymphangiogenesis and lymph node metastasis via NF-κB signaling activation in cervical carcinoma.
    8. HNRNPA1-mediated alternative polyadenylation of HN1 contributes to cancer- and senescence-related phenotypes.
      Title: HNRNPA1-mediated 3' UTR length changes of HN1 contributes to cancer- and senescence-associated phenotypes.
    9. Downregulation of MYC abrogated the effect of HN1 overexpression in breast cancer cell lines. Taken together, these data reveal that HN1 promotes the progression of breast cancer by upregulating MYC expression, and might be a therapeutic target for breast cancer.
      Title: HN1 contributes to migration, invasion, and tumorigenesis of breast cancer by enhancing MYC activity.
    10. Data report that HN1 is an essential factor for beta-catenin turnover and signaling, augments cell growth and migration in prostate cancer cells.
      Title: HN1 negatively influences the β-catenin/E-cadherin interaction, and contributes to migration in prostate cells.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in intercellular bridge IDA
    Inferred from Direct Assay
    more info
    		  
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    jupiter microtubule associated homolog 1
    Names
    androgen-regulated protein 2
    hematological and neurological expressed 1 protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002032.3 → NP_001002032.1  jupiter microtubule associated homolog 1 isoform 2

      See identical proteins and their annotated locations for NP_001002032.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) encodes the longest isoform (2).
      Source sequence(s)
      AF086910, AY322169
      Consensus CDS
      CCDS32729.1
      UniProtKB/Swiss-Prot
      Q9UK76
      Related
      ENSP00000348316.4, ENST00000356033.8
      Conserved Domains (1) summary
      pfam17054
      Location:1 → 58
      JUPITER; Microtubule-Associated protein Jupiter

    2. NM_001002033.3 → NP_001002033.1  jupiter microtubule associated homolog 1 isoform 3

      See identical proteins and their annotated locations for NP_001002033.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and contains multiple coding region differences, one of which results in a frameshift and an early stop codon, compared to variant 2. Variants 3, 5 and 6 encode the same isoform (3), which is shorter and has distinct N- and C-termini, compared to isoform 2.
      Source sequence(s)
      AF086910, AY322170
      Consensus CDS
      CCDS45772.1
      UniProtKB/Swiss-Prot
      Q9UK76

    3. NM_001288609.1 → NP_001275538.1  jupiter microtubule associated homolog 1 isoform 3

      See identical proteins and their annotated locations for NP_001275538.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and contains multiple coding region differences, one of which results in a frameshift and an early stop codon, compared to variant 2. Variants 3, 5 and 6 encode the same isoform (3), which is shorter and has distinct N- and C-termini, compared to isoform 2.
      Source sequence(s)
      AF086910, AW675726, BC039343, DB451153
      Consensus CDS
      CCDS45772.1
      UniProtKB/Swiss-Prot
      Q9UK76
      Related
      ENSP00000464266.1, ENST00000476258.5

    4. NM_001288610.1 → NP_001275539.1  jupiter microtubule associated homolog 1 isoform 3

      See identical proteins and their annotated locations for NP_001275539.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and contains multiple coding region differences, one of which results in a frameshift and an early stop codon, compared to variant 2. Variants 3, 5 and 6 encode the same isoform (3), which is shorter and has distinct N- and C-termini, compared to isoform 2.
      Source sequence(s)
      AF086910, AK308253, AW675726
      Consensus CDS
      CCDS45772.1
      UniProtKB/Swiss-Prot
      Q9UK76
      Related
      ENSP00000462834.1, ENST00000482348.5

    5. NM_001288611.2 → NP_001275540.1  jupiter microtubule associated homolog 1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate exon in the 3' coding region, resulting in a frameshift and an early stop codon, compared to variant 2. It encodes isoform 4, which is shorter and has a distinct C-terminus, compared to isoform 2.
      Source sequence(s)
      AC022211, AF086910, BG779109
      UniProtKB/TrEMBL
      J3KT51
      Conserved Domains (1) summary
      pfam17054
      Location:1 → 58
      JUPITER; Microtubule-Associated protein Jupiter

    6. NM_016185.4 → NP_057269.1  jupiter microtubule associated homolog 1 isoform 1

      See identical proteins and their annotated locations for NP_057269.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) contains an alternate exon in the 3' coding region, resulting in a frameshift and an early stop codon, compared to variant 2. It encodes isoform 1, which is shorter and has a distinct C-terminus, compared to isoform 2.
      Source sequence(s)
      AF266846, AW675726
      Consensus CDS
      CCDS45771.1
      UniProtKB/Swiss-Prot
      B2R6K3, Q53FG7, Q7Z2D2, Q7Z2F0, Q9UK76
      Related
      ENSP00000387059.3, ENST00000409753.8
      Conserved Domains (1) summary
      pfam17054
      Location:1 → 58
      JUPITER; Microtubule-Associated protein Jupiter

    RNA

    1. NR_109933.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) uses an alternate splice site in an internal exon and contains an alternate internal exon, compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AF086910, DA604735

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      75135243..75154512 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024450779.2 → XP_024306547.1  jupiter microtubule associated homolog 1 isoform X1

      Related
      ENSP00000462478.1, ENST00000481647.5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      76026703..76045989 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UK76.3 GenPept UniProtKB/Swiss-Prot:Q9UK76

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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