PRKAB1 protein kinase AMP-activated non-catalytic subunit beta 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PRKAB1provided by HGNC
Official Full Name: protein kinase AMP-activated non-catalytic subunit beta 1provided by HGNC
Primary source: HGNC:HGNC:9378
See related: Ensembl:ENSG00000111725 MIM:602740; AllianceGenome:HGNC:9378
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: AMPK; HAMPKb
Summary: The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in kidney (RPKM 25.5), bone marrow (RPKM 15.9) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12q24.23

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (119667952..119681619)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (119655225..119668903)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (120105938..120119424)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

[Extracellular Matrix Stiffness Induces Mitochondrial Morphological Heterogeneity via AMPK Activation].
Title: [Extracellular Matrix Stiffness Induces Mitochondrial Morphological Heterogeneity via AMPK Activation].
Endothelial H2S-AMPK dysfunction upregulates the angiocrine factor PAI-1 and contributes to lung fibrosis.
Title: Endothelial H(2)S-AMPK dysfunction upregulates the angiocrine factor PAI-1 and contributes to lung fibrosis.
Phosphorylation of INF2 by AMPK promotes mitochondrial fission and oncogenic function in endometrial cancer.
Title: Phosphorylation of INF2 by AMPK promotes mitochondrial fission and oncogenic function in endometrial cancer.
Direct effects of adipocyte lipolysis on AMPK through intracellular long-chain acyl-CoA signaling.
Title: Direct effects of adipocyte lipolysis on AMPK through intracellular long-chain acyl-CoA signaling.
AMPK is a mechano-metabolic sensor linking cell adhesion and mitochondrial dynamics to Myosin-dependent cell migration.
Title: AMPK is a mechano-metabolic sensor linking cell adhesion and mitochondrial dynamics to Myosin-dependent cell migration.
Exosomal miR-663b from "M1" macrophages promotes pulmonary artery vascular smooth muscle cell dysfunction through inhibiting the AMPK/Sirt1 axis.
Title: Exosomal miR-663b from "M1" macrophages promotes pulmonary artery vascular smooth muscle cell dysfunction through inhibiting the AMPK/Sirt1 axis.
Promoting AMPK/SR-A1-mediated clearance of HMGB1 attenuates chemotherapy-induced peripheral neuropathy.
Title: Promoting AMPK/SR-A1-mediated clearance of HMGB1 attenuates chemotherapy-induced peripheral neuropathy.
AMPKbeta1 and AMPKbeta2 define an isoform-specific gene signature in human pluripotent stem cells, differentially mediating cardiac lineage specification.
Title: AMPKβ1 and AMPKβ2 define an isoform-specific gene signature in human pluripotent stem cells, differentially mediating cardiac lineage specification.
Inhibitory mechanism of muscone in liver cancer involves the induction of apoptosis and autophagy.
Title: Inhibitory mechanism of muscone in liver cancer involves the induction of apoptosis and autophagy.
CAMKK2 and AMPK have opposing effects on lipogenesis, providing a potential mechanism for their contrasting effects on prostate cancer progression in vivo
Title: CAMKK2 Promotes Prostate Cancer Independently of AMPK via Increased Lipogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (115)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat-induced LTR transactivation is reversed by tanshinone II A through the AMPK-Nampt pathway	PubMed
	tat	Knockdown of SIRT1 by its inhibitor or siRNA results in Tat-mediated reduction of phosphorylation of AMP-activated protein kinase (AMPK) and downstream acetyl-CoA carboxylase (ACC)	PubMed
Vif	vif	Protein kinase A (PKA) binds and phosphorylates A3G at Thr32 in vitro and in vivo. This phosphorylation event reduces the binding of A3G to Vif and its subsequent ubiquitination and degradation	PubMed
Vpr	vpr	HIV-1 Vpr directly interacts with PKA and is phosphorylated at position Ser79 by PKA. PKA activity is necessary for virion-delivered Vpr cell cycle arrest	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

L18426 (e-PCR)
- UniSTS:34648

RH98832 (e-PCR)
- UniSTS:85365

G19710 (e-PCR)
- UniSTS:10112

A001W18 (e-PCR)
- UniSTS:10113

WI-13962 (e-PCR)
- UniSTS:25505

WI-19637 (e-PCR)
- UniSTS:4787

G44705 (e-PCR)
- UniSTS:95180

SHGC-81002 (e-PCR)
- UniSTS:102624

RH48906 (e-PCR)
- UniSTS:74209

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to nutrient levels	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to nutrient levels	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to nutrient levels	NAS Non-traceable Author Statement more info	PubMed
involved_in fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in nail development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleoplasm	TAS Traceable Author Statement more info
part_of nucleotide-activated protein kinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of nucleotide-activated protein kinase complex	IPI Inferred from Physical Interaction more info	PubMed
part_of nucleotide-activated protein kinase complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: 5'-AMP-activated protein kinase subunit beta-1

Names: 5'-AMP-activated protein kinase beta-1 subunit; AMP-activated protein kinase beta subunit; AMPK beta -1 chain; AMPK beta 1; AMPK subunit beta-1; AMPKb; protein kinase, AMP-activated, beta 1 non-catalytic subunit; protein kinase, AMP-activated, noncatalytic, beta-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_006253.5 → NP_006244.2 5'-AMP-activated protein kinase subunit beta-1

See identical proteins and their annotated locations for NP_006244.2

Status: REVIEWED

Source sequence(s)

AF022116, BC017671, BU539177

Consensus CDS

CCDS9191.1

UniProtKB/Swiss-Prot

Q9UBV0, Q9UE20, Q9UEX2, Q9Y478, Q9Y6V8

UniProtKB/TrEMBL

B2R6A0

Related

ENSP00000229328.5, ENST00000229328.10

Conserved Domains (2) summary

smart01010
Location:181 → 270

AMPKBI; 5'-AMP-activated protein kinase beta subunit, interation domain

pfam16561
Location:78 → 161

AMPK1_CBM; Glycogen recognition site of AMP-activated protein kinase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000012.12 Reference GRCh38.p14 Primary Assembly

Range

119667952..119681619

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005253909.2 → XP_005253966.1 5'-AMP-activated protein kinase subunit beta-1 isoform X1

See identical proteins and their annotated locations for XP_005253966.1

UniProtKB/Swiss-Prot

Q9UBV0, Q9UE20, Q9UEX2, Q9Y478, Q9Y6V8

UniProtKB/TrEMBL

B2R6A0

Related

ENSP00000441369.1, ENST00000541640.5

Conserved Domains (2) summary

smart01010
Location:181 → 270

AMPKBI; 5'-AMP-activated protein kinase beta subunit, interation domain

pfam16561
Location:78 → 161

AMPK1_CBM; Glycogen recognition site of AMP-activated protein kinase

Alternate T2T-CHM13v2.0

Genomic

NC_060936.1 Alternate T2T-CHM13v2.0

Range

119655225..119668903

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054372521.1 → XP_054228496.1 5'-AMP-activated protein kinase subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

Q9UBV0, Q9UE20, Q9UEX2, Q9Y478, Q9Y6V8

UniProtKB/TrEMBL

B2R6A0