U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    HCAR3 hydroxycarboxylic acid receptor 3 [ Homo sapiens (human) ]

    Gene ID: 8843, updated on 10-Dec-2024

    Summary

    Official Symbol
    HCAR3provided by HGNC
    Official Full Name
    hydroxycarboxylic acid receptor 3provided by HGNC
    Primary source
    HGNC:HGNC:16824
    See related
    Ensembl:ENSG00000255398 MIM:606039; AllianceGenome:HGNC:16824
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HCA3; HM74; PUMAG; Puma-g; GPR109B
    Summary
    Predicted to enable GTP binding activity; nicotinic acid receptor activity; and purinergic nucleotide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in cell junction. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See HCAR3 in Genome Data Viewer
    Location:
    12q24.31
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (122714756..122716811, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (122710140..122712195, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (123199303..123201358, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene hydroxycarboxylic acid receptor 2 Neighboring gene MPRA-validated peak2022 silencer Neighboring gene microRNA 9902-2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5019 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:123214153-123214820 Neighboring gene hydroxycarboxylic acid receptor 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:123218665-123219164 Neighboring gene Sharpr-MPRA regulatory region 1215 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:123235867-123236728 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5020 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7236 Neighboring gene density regulated re-initiation and release factor

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of hydroxycarboxylic acid receptor 3 (HCAR3) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables nicotinic acid receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    hydroxycarboxylic acid receptor 3
    Names
    G-protein coupled receptor 109B
    G-protein coupled receptor HM74
    G-protein coupled receptor HM74B
    GTP-binding protein
    hydroxy-carboxylic acid receptor 3
    niacin receptor 2
    nicotinic acid receptor 2
    putative chemokine receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006018.3NP_006009.2  hydroxycarboxylic acid receptor 3

      See identical proteins and their annotated locations for NP_006009.2

      Status: VALIDATED

      Source sequence(s)
      BC047891, BI908162, CB529340, CD366840, CU451507, DA948030, DA953971
      Consensus CDS
      CCDS53842.1
      UniProtKB/Swiss-Prot
      A8K4G5, B2R830, E9PI97, P49019, Q8NGE4
      UniProtKB/TrEMBL
      A0A4Y1JWR6
      Related
      ENSP00000436714.2, ENST00000528880.3
      Conserved Domains (1) summary
      pfam00001
      Location:44294
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      122714756..122716811 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      122710140..122712195 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)