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    NSMCE3 NSE3 homolog, SMC5-SMC6 complex component [ Homo sapiens (human) ]

    Gene ID: 56160, updated on 10-Dec-2024

    Summary

    Official Symbol
    NSMCE3provided by HGNC
    Official Full Name
    NSE3 homolog, SMC5-SMC6 complex componentprovided by HGNC
    Primary source
    HGNC:HGNC:7677
    See related
    Ensembl:ENSG00000185115 MIM:608243; AllianceGenome:HGNC:7677
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HCA4; LICS; NSE3; NDNL2; MAGEG1; MAGEL3
    Summary
    The protein encoded by this gene is part of the SMC5-6 chromatin reorganizing complex and is a member of the MAGE superfamily. This is an intronless gene. [provided by RefSeq, May 2011]
    Orthologs
    NEW
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    Genomic context

    See NSMCE3 in Genome Data Viewer
    Location:
    15q13.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (29264989..29269822, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (27043359..27048192, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (29557193..29562026, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:29141496-29142056 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:29144665-29144856 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:29145615-29146168 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:29146721-29147272 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:29147273-29147824 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:29148359-29148860 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:29148861-29149360 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:29210321-29210843 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:29211011-29211600 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:29227603-29228102 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:29240656-29241156 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:29246587-29247088 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:29247601-29248114 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:29247089-29247588 Neighboring gene amyloid beta precursor protein binding family A member 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:29283117-29283618 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:29283619-29284118 Neighboring gene MPRA-validated peak2281 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr15:29307813-29308019 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:29356146-29356657 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:29356658-29357170 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:29379537-29380038 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:29407365-29408165 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:29424556-29425172 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:29432077-29432890 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:29454119-29454628 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:29454629-29455137 Neighboring gene endosomal transmembrane epsin interactor 2 Neighboring gene DDB1 and CUL4 associated factor 6 pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:29561321-29561822 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:29561823-29562322 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9166 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:29611925-29612479 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:29637062-29638044 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:29699994-29700185 Neighboring gene MPRA-validated peak2283 silencer Neighboring gene Sharpr-MPRA regulatory region 8593 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr15:29903026-29903716 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr15:29903717-29904407 Neighboring gene Sharpr-MPRA regulatory region 3573 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:29924029-29924548 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:29943839-29944339 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:29967552-29968082 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:29968083-29968613 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:29970293-29970793 Neighboring gene tubulin beta class I pseudogene 8 Neighboring gene lung cancer immune cell infiltration associated lncRNA

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    part_of Smc5-Smc6 complex PubMed 
    part_of Smc5-Smc6 complex PubMed 
    located_in chromosome, telomeric region PubMed 
    located_in cytoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  

    General protein information

    Preferred Names
    non-structural maintenance of chromosomes element 3 homolog
    Names
    MAGE-G1 antigen
    hepatocellular carcinoma-associated protein 4
    hepatocellular carcinoma-associated protein HCA4
    melanoma antigen, family G, 1
    melanoma-associated antigen G1
    necdin-like 2, SMC5-SMC6 complex component
    necdin-like gene 2
    necdin-like protein 2
    non-SMC element 3 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_053143.1 RefSeqGene

      Range
      5008..9841
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138704.4 → NP_619649.1  non-structural maintenance of chromosomes element 3 homolog

      See identical proteins and their annotated locations for NP_619649.1

      Status: REVIEWED

      Source sequence(s)
      AC061965, AU310582, BC053999
      Consensus CDS
      CCDS10023.1
      UniProtKB/Swiss-Prot
      Q8IW16, Q8TEI6, Q96MG7, Q9H214
      Related
      ENSP00000330694.4, ENST00000332303.6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      29264989..29269822 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_011332701.1 Reference GRCh38.p14 PATCHES

      Range
      1428056..1432889 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_187660.1 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      1540540..1545373 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      27043359..27048192 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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