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    FOXL2NB FOXL2 neighbor [ Homo sapiens (human) ]

    Gene ID: 401089, updated on 10-Dec-2024

    Summary

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    Official Symbol
    FOXL2NBprovided by HGNC
    Official Full Name
    FOXL2 neighborprovided by HGNC
    Primary source
    HGNC:HGNC:34428
    See related
    Ensembl:ENSG00000206262 AllianceGenome:HGNC:34428
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C3orf72
    Summary
    Located in fibrillar center. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in ovary (RPKM 15.2) and endometrium (RPKM 8.8) See more
    Orthologs
    all
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    Genomic context

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    See FOXL2NB in Genome Data Viewer
    Location:
    3q22.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (138947217..138953990)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (141688060..141694996)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (138666059..138672832)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 3980 Neighboring gene long intergenic non-protein coding RNA 1391 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:138663365-138663954 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:138665995-138666223 Neighboring gene forkhead box L2 Neighboring gene proline rich 23A Neighboring gene proline rich 23B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. New STAT3-FOXL2 pathway and its function in cancer cells. Han Y, et al. BMC Mol Cell Biol, 2019 Jun 20. PMID 31221094, Free PMC Article
    2. Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity. Kim JJ, et al. Genes Dev, 2019 Dec 1. PMID 31753913, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ52231

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in fibrillar center IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    FOXL2 neighbor protein
    Names
    FLJ43329 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029796.1 RefSeqGene

      Range
      4984..11757
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001040061.3 → NP_001035150.1  FOXL2 neighbor protein

      See identical proteins and their annotated locations for NP_001035150.1

      Status: VALIDATED

      Source sequence(s)
      AC092947, AC130416, AK125319
      Consensus CDS
      CCDS43155.1
      UniProtKB/Swiss-Prot
      A6NGX0, Q6ZUU3
      Related
      ENSP00000372651.3, ENST00000383165.4

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      138947217..138953990
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005247443.4 → XP_005247500.1  FOXL2 neighbor protein isoform X2

    2. XM_024453517.2 → XP_024309285.1  FOXL2 neighbor protein isoform X1

      UniProtKB/TrEMBL
      B7Z962
      Conserved Domains (1) summary
      cl26247
      Location:106 → 185
      DNA_pol3_delta2; DNA polymerase III, delta subunit

    3. XM_024453518.2 → XP_024309286.1  FOXL2 neighbor protein isoform X1

      UniProtKB/TrEMBL
      B7Z962
      Conserved Domains (1) summary
      cl26247
      Location:106 → 185
      DNA_pol3_delta2; DNA polymerase III, delta subunit

    4. XM_047448095.1 → XP_047304051.1  FOXL2 neighbor protein isoform X1

      UniProtKB/TrEMBL
      B7Z962

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      141688060..141694996
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054346486.1 → XP_054202461.1  FOXL2 neighbor protein isoform X2

    2. XM_054346484.1 → XP_054202459.1  FOXL2 neighbor protein isoform X1

    3. XM_054346483.1 → XP_054202458.1  FOXL2 neighbor protein isoform X1

    4. XM_054346485.1 → XP_054202460.1  FOXL2 neighbor protein isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZUU3.1 GenPept UniProtKB/Swiss-Prot:Q6ZUU3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials