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    ZNF613 zinc finger protein 613 [ Homo sapiens (human) ]

    Gene ID: 79898, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ZNF613provided by HGNC
    Official Full Name
    zinc finger protein 613provided by HGNC
    Primary source
    HGNC:HGNC:25827
    See related
    Ensembl:ENSG00000176024 AllianceGenome:HGNC:25827
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in prostate (RPKM 6.4), placenta (RPKM 2.1) and 22 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF613 in Genome Data Viewer
    Location:
    19q13.41
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (51927472..51946621)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (55014667..55033819)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (52430725..52449874)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ZNF649 antisense RNA 1 Neighboring gene zinc finger protein 649 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:52404806-52405052 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:52406403-52406948 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:52408039-52408583 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:52408912-52409536 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:52410420-52411095 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:52411096-52411770 Neighboring gene zinc finger protein 41 pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:52429745-52430508 Neighboring gene ZNF350 antisense RNA 1 Neighboring gene zinc finger protein 350 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:52489558-52490433 Neighboring gene zinc finger protein 615 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15032

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Genomic Regions Associated With Gestation Length Detected Using Whole-Genome Sequence Data Differ Between Dairy and Beef Cattle. Purfield DC, et al. Front Genet, 2019. PMID 31749838, Free PMC Article
    2. USP9X deubiquitinates and stabilizes CDC123 to promote breast carcinogenesis through regulating cell cycle. Song N, et al. Mol Carcinog, 2023 Oct. PMID 37314216
    3. Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling. Kouranti I, et al. Int J Mol Sci, 2022 May 5. PMID 35563538, Free PMC Article
    4. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ13590

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 613

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031721.4 → NP_001026891.2  zinc finger protein 613 isoform 1

      See identical proteins and their annotated locations for NP_001026891.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC011460, AK027565, BC057776, CA427456
      Consensus CDS
      CCDS33089.1
      UniProtKB/Swiss-Prot
      Q6PF04, Q96SS9
      Related
      ENSP00000293471.5, ENST00000293471.11
      Conserved Domains (6) summary
      smart00349
      Location:8 → 67
      KRAB; krueppel associated box
      COG5048
      Location:176 → 531
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:374 → 394
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:484 → 506
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:8 → 47
      KRAB; KRAB box
      pfam13465
      Location:414 → 439
      zf-H2C2_2; Zinc-finger double domain

    2. NM_024840.4 → NP_079116.2  zinc finger protein 613 isoform 2

      See identical proteins and their annotated locations for NP_079116.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two alternate exons and uses a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC011460, AK027565, CA427456
      Consensus CDS
      CCDS12844.1
      UniProtKB/Swiss-Prot
      Q6PF04
      Related
      ENSP00000375671.3, ENST00000391794.8
      Conserved Domains (5) summary
      smart00349
      Location:1 → 31
      KRAB; krueppel associated box
      COG5048
      Location:140 → 495
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:338 → 358
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:448 → 470
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:378 → 403
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      51927472..51946621
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      55014667..55033819
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PF04.2 GenPept UniProtKB/Swiss-Prot:Q6PF04

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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