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    FAM13B family with sequence similarity 13 member B [ Homo sapiens (human) ]

    Gene ID: 51306, updated on 27-Nov-2024

    Summary

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    Official Symbol
    FAM13Bprovided by HGNC
    Official Full Name
    family with sequence similarity 13 member Bprovided by HGNC
    Primary source
    HGNC:HGNC:1335
    See related
    Ensembl:ENSG00000031003 MIM:609371; AllianceGenome:HGNC:1335
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    N61; KHCHP; C5orf5; FAM13B1; ARHGAP49
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in regulation of small GTPase mediated signal transduction. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis (RPKM 17.1), endometrium (RPKM 11.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See FAM13B in Genome Data Viewer
    Location:
    5q31.2
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (137937960..138052178, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (138464356..138578527, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (137273649..137374342, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986368 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23188 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23189 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:137199613-137199779 Neighboring gene PKD2L2 divergent transcript Neighboring gene myotilin Neighboring gene polycystin 2 like 2, transient receptor potential cation channel Neighboring gene MPRA-validated peak5488 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr5:137338418-137338597 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23190 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:137366081-137366582 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23191 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:137367957-137368840 Neighboring gene uncharacterized LOC124901077 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23192 Neighboring gene FAM13B antisense RNA 1 Neighboring gene RNA, U6 small nuclear 1148, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:137425944-137426482 Neighboring gene Wnt family member 8A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. cDNA cloning and genomic structure of three genes localized to human chromosome band 5q31 encoding potential nuclear proteins. Lai F, et al. Genomics, 2000 Nov 15. PMID 11087669
    2. The eukaryotic elongation factor eEF1A1 interacts with SAMHD1. Morrissey C, et al. Biochem J, 2015 Feb 15. PMID 25423367
    3. Transcript map and comparative analysis of the 1.5-Mb commonly deleted segment of human 5q31 in malignant myeloid diseases with a del(5q). Lai F, et al. Genomics, 2001 Jan 15. PMID 11161817
    4. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. Hu RM, et al. Proc Natl Acad Sci U S A, 2000 Aug 15. PMID 10931946, Free PMC Article
    5. Image-based genome-wide siRNA screen identifies selective autophagy factors. Orvedahl A, et al. Nature, 2011 Dec 1. PMID 22020285, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ26735, MGC57159, DKFZp667F249

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    protein FAM13B
    Names
    GAP-like protein N61
    family with sequence similarity 13, member B1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001101800.3 → NP_001095270.1  protein FAM13B isoform 2

      See identical proteins and their annotated locations for NP_001095270.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC113382, AF251038, AW592656, BC048965
      Consensus CDS
      CCDS47269.1
      UniProtKB/TrEMBL
      B2RAJ9
      Related
      ENSP00000388521.2, ENST00000420893.6
      Conserved Domains (2) summary
      cd04393
      Location:19 → 205
      RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
      cl26235
      Location:829 → 868
      RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

    2. NM_001101801.3 → NP_001095271.1  protein FAM13B isoform 3

      See identical proteins and their annotated locations for NP_001095271.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has a distinct 5' UTR, lacks an in-frame portion of the 5' coding region, contains an alternate in-frame exon in the mid-coding region, and lacks an alternate in-frame exon in the 3' coding region, as compared to variant 1. This results in a shorter isoform (3) that has a truncated N-terminus, compared to isoform 1.
      Source sequence(s)
      AC113382, AF251038, AW592656, BC041335, BC048965, DA499233
      Consensus CDS
      CCDS47270.1
      UniProtKB/TrEMBL
      B2RAJ9
      Related
      ENSP00000394669.2, ENST00000425075.6
      Conserved Domains (2) summary
      cl02570
      Location:1 → 87
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl26235
      Location:733 → 772
      RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

    3. NM_001385866.1 → NP_001372795.1  protein FAM13B isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC106753, AC113382
      UniProtKB/TrEMBL
      B2RAJ9
      Conserved Domains (2) summary
      cl02570
      Location:1 → 87
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl26235
      Location:739 → 778
      RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

    4. NM_001385867.1 → NP_001372796.1  protein FAM13B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC106753, AC113382
      Consensus CDS
      CCDS47269.1
      UniProtKB/TrEMBL
      B2RAJ9
      Conserved Domains (2) summary
      cd04393
      Location:19 → 205
      RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
      cl26235
      Location:829 → 868
      RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

    5. NM_001385868.1 → NP_001372797.1  protein FAM13B isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC106753, AC113382
      UniProtKB/TrEMBL
      B2RAJ9
      Conserved Domains (2) summary
      cd04393
      Location:19 → 205
      RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
      cl26235
      Location:851 → 890
      RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

    6. NM_001385869.1 → NP_001372798.1  protein FAM13B isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC106753, AC113382
      Conserved Domains (1) summary
      cl26235
      Location:587 → 626
      RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

    7. NM_001385870.1 → NP_001372799.1  protein FAM13B isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC106753, AC113382
      UniProtKB/TrEMBL
      B2RAJ9
      Conserved Domains (2) summary
      cd04393
      Location:19 → 205
      RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
      cl26235
      Location:799 → 838
      RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

    8. NM_001385872.1 → NP_001372801.1  protein FAM13B isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC106753, AC113382
      UniProtKB/TrEMBL
      B2RAJ9
      Conserved Domains (2) summary
      cl02570
      Location:1 → 87
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl26235
      Location:761 → 800
      RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

    9. NM_001385873.1 → NP_001372802.1  protein FAM13B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC106753, AC113382
      Consensus CDS
      CCDS47270.1
      UniProtKB/TrEMBL
      B2RAJ9
      Conserved Domains (2) summary
      cl02570
      Location:1 → 87
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl26235
      Location:733 → 772
      RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

    10. NM_001385874.1 → NP_001372803.1  protein FAM13B isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC106753, AC113382
      UniProtKB/TrEMBL
      B2RAJ9
      Conserved Domains (2) summary
      cd04393
      Location:19 → 205
      RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
      cl26235
      Location:827 → 866
      RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

    11. NM_001385921.1 → NP_001372850.1  protein FAM13B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC106753, AC113382
      Consensus CDS
      CCDS4195.1
      UniProtKB/Swiss-Prot
      D3DQB5, G3V0H9, Q3ZCR0, Q6PGQ2, Q9NYF5, Q9P0I7
      UniProtKB/TrEMBL
      A0A2X0SG06, B2RAJ9
      Conserved Domains (2) summary
      cd04393
      Location:19 → 205
      RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
      cl26235
      Location:857 → 896
      RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

    12. NM_001385976.1 → NP_001372905.1  protein FAM13B isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC106753, AC113382
      UniProtKB/TrEMBL
      B2RAJ9
      Conserved Domains (2) summary
      cl02570
      Location:1 → 87
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl26235
      Location:761 → 800
      RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

    13. NM_001385977.1 → NP_001372906.1  protein FAM13B isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC106753, AC113382
      UniProtKB/TrEMBL
      B2RAJ9
      Conserved Domains (2) summary
      cl02570
      Location:1 → 87
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl26235
      Location:739 → 778
      RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

    14. NM_001385978.1 → NP_001372907.1  protein FAM13B isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC106753, AC113382
      Conserved Domains (1) summary
      cl26235
      Location:639 → 678
      RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

    15. NM_001385979.1 → NP_001372908.1  protein FAM13B isoform 14

      Status: VALIDATED

      Source sequence(s)
      AC106753, AC113382
      UniProtKB/TrEMBL
      B2RAJ9
      Conserved Domains (2) summary
      cl02570
      Location:1 → 87
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl26235
      Location:711 → 750
      RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

    16. NM_001385980.1 → NP_001372909.1  protein FAM13B isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC106753, AC113382
      UniProtKB/TrEMBL
      B2RAJ9
      Conserved Domains (2) summary
      cd04393
      Location:19 → 205
      RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
      cl26235
      Location:851 → 890
      RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

    17. NM_001385991.1 → NP_001372920.1  protein FAM13B isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC106753, AC113382
      UniProtKB/TrEMBL
      B2RAJ9
      Conserved Domains (2) summary
      cd04393
      Location:19 → 205
      RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
      cl26235
      Location:797 → 836
      RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

    18. NM_001385992.1 → NP_001372921.1  protein FAM13B isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC106753, AC113382
      UniProtKB/TrEMBL
      B2RAJ9
      Conserved Domains (2) summary
      cd04393
      Location:19 → 205
      RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
      cl26235
      Location:827 → 866
      RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

    19. NM_001385994.1 → NP_001372923.1  protein FAM13B isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC106753, AC113382
      Consensus CDS
      CCDS93788.1
      UniProtKB/TrEMBL
      A0A8I5KSB9, B2RAJ9
      Related
      ENSP00000509788.1, ENST00000689681.1
      Conserved Domains (2) summary
      cd04393
      Location:19 → 205
      RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
      cl26235
      Location:879 → 918
      RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

    20. NM_001385995.1 → NP_001372924.1  protein FAM13B isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC106753, AC113382
      UniProtKB/TrEMBL
      B2RAJ9
      Conserved Domains (2) summary
      cl02570
      Location:1 → 87
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl26235
      Location:679 → 718
      RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

    21. NM_001385996.1 → NP_001372925.1  protein FAM13B isoform 16

      Status: VALIDATED

      Source sequence(s)
      AC106753, AC113382
      Conserved Domains (1) summary
      cl26235
      Location:667 → 706
      RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

    22. NM_001385997.1 → NP_001372926.1  protein FAM13B isoform 17

      Status: VALIDATED

      Source sequence(s)
      AC106753, AC113382
      UniProtKB/TrEMBL
      B2RAJ9
      Conserved Domains (2) summary
      cd04393
      Location:19 → 205
      RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
      cl26235
      Location:777 → 816
      RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

    23. NM_001385998.1 → NP_001372927.1  protein FAM13B isoform 18

      Status: VALIDATED

      Source sequence(s)
      AC106753, AC113382
      Conserved Domains (1) summary
      cl26235
      Location:597 → 636
      RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

    24. NM_001385999.1 → NP_001372928.1  protein FAM13B isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC106753, AC113382
      UniProtKB/TrEMBL
      B2RAJ9
      Conserved Domains (2) summary
      cl02570
      Location:1 → 87
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl26235
      Location:761 → 800
      RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

    25. NM_016603.4 → NP_057687.2  protein FAM13B isoform 1

      See identical proteins and their annotated locations for NP_057687.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC113382, AF251038, AW592656, BU183000, DA499233
      Consensus CDS
      CCDS4195.1
      UniProtKB/Swiss-Prot
      D3DQB5, G3V0H9, Q3ZCR0, Q6PGQ2, Q9NYF5, Q9P0I7
      UniProtKB/TrEMBL
      A0A2X0SG06, B2RAJ9
      Related
      ENSP00000033079.3, ENST00000033079.7
      Conserved Domains (2) summary
      cd04393
      Location:19 → 205
      RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
      cl26235
      Location:857 → 896
      RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

    RNA

    1. NR_169814.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC106753, AC113382

    2. NR_169815.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC106753, AC113382

    3. NR_169822.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC106753, AC113382

    4. NR_169823.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC106753, AC113382

    5. NR_169824.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC106753, AC113382

    6. NR_169825.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC106753, AC113382

    7. NR_169826.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC106753, AC113382

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      137937960..138052178 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006714648.2 → XP_006714711.1  protein FAM13B isoform X1

      See identical proteins and their annotated locations for XP_006714711.1

      UniProtKB/TrEMBL
      A0A8I5KSB9, B2RAJ9
      Conserved Domains (2) summary
      cd04393
      Location:19 → 205
      RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
      cl26235
      Location:879 → 918
      RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

    2. XM_024446107.2 → XP_024301875.1  protein FAM13B isoform X1

      UniProtKB/TrEMBL
      A0A8I5KSB9, B2RAJ9
      Conserved Domains (2) summary
      cd04393
      Location:19 → 205
      RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
      cl26235
      Location:879 → 918
      RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

    3. XM_017009550.2 → XP_016865039.1  protein FAM13B isoform X2

      UniProtKB/Swiss-Prot
      D3DQB5, G3V0H9, Q3ZCR0, Q6PGQ2, Q9NYF5, Q9P0I7
      UniProtKB/TrEMBL
      A0A2X0SG06, B2RAJ9
      Conserved Domains (2) summary
      cd04393
      Location:19 → 205
      RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
      cl26235
      Location:857 → 896
      RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

    4. XM_011543450.2 → XP_011541752.1  protein FAM13B isoform X1

      See identical proteins and their annotated locations for XP_011541752.1

      UniProtKB/TrEMBL
      A0A8I5KSB9, B2RAJ9
      Conserved Domains (2) summary
      cd04393
      Location:19 → 205
      RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
      cl26235
      Location:879 → 918
      RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

    5. XM_011543448.2 → XP_011541750.1  protein FAM13B isoform X1

      See identical proteins and their annotated locations for XP_011541750.1

      UniProtKB/TrEMBL
      A0A8I5KSB9, B2RAJ9
      Conserved Domains (2) summary
      cd04393
      Location:19 → 205
      RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
      cl26235
      Location:879 → 918
      RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

    6. XM_047417286.1 → XP_047273242.1  protein FAM13B isoform X4

    7. XM_047417285.1 → XP_047273241.1  protein FAM13B isoform X3

    8. XM_011543449.2 → XP_011541751.1  protein FAM13B isoform X1

      See identical proteins and their annotated locations for XP_011541751.1

      UniProtKB/TrEMBL
      A0A8I5KSB9, B2RAJ9
      Conserved Domains (2) summary
      cd04393
      Location:19 → 205
      RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
      cl26235
      Location:879 → 918
      RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

    9. XM_047417287.1 → XP_047273243.1  protein FAM13B isoform X4

    10. XM_047417284.1 → XP_047273240.1  protein FAM13B isoform X2

      UniProtKB/Swiss-Prot
      D3DQB5, G3V0H9, Q3ZCR0, Q6PGQ2, Q9NYF5, Q9P0I7
      UniProtKB/TrEMBL
      A0A2X0SG06

    11. XM_047417283.1 → XP_047273239.1  protein FAM13B isoform X1

      UniProtKB/TrEMBL
      A0A8I5KSB9

    12. XM_047417288.1 → XP_047273244.1  protein FAM13B isoform X4

    13. XM_017009549.2 → XP_016865038.1  protein FAM13B isoform X2

      UniProtKB/Swiss-Prot
      D3DQB5, G3V0H9, Q3ZCR0, Q6PGQ2, Q9NYF5, Q9P0I7
      UniProtKB/TrEMBL
      A0A2X0SG06, B2RAJ9
      Conserved Domains (2) summary
      cd04393
      Location:19 → 205
      RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
      cl26235
      Location:857 → 896
      RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

    14. XM_047417282.1 → XP_047273238.1  protein FAM13B isoform X1

      UniProtKB/TrEMBL
      A0A8I5KSB9

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      138464356..138578527 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054352764.1 → XP_054208739.1  protein FAM13B isoform X1

      UniProtKB/TrEMBL
      A0A8I5KSB9

    2. XM_054352767.1 → XP_054208742.1  protein FAM13B isoform X1

      UniProtKB/TrEMBL
      A0A8I5KSB9

    3. XM_054352770.1 → XP_054208745.1  protein FAM13B isoform X2

      UniProtKB/Swiss-Prot
      D3DQB5, G3V0H9, Q3ZCR0, Q6PGQ2, Q9NYF5, Q9P0I7
      UniProtKB/TrEMBL
      A0A2X0SG06

    4. XM_054352766.1 → XP_054208741.1  protein FAM13B isoform X1

      UniProtKB/TrEMBL
      A0A8I5KSB9

    5. XM_054352765.1 → XP_054208740.1  protein FAM13B isoform X1

      UniProtKB/TrEMBL
      A0A8I5KSB9

    6. XM_054352772.1 → XP_054208747.1  protein FAM13B isoform X4

    7. XM_054352771.1 → XP_054208746.1  protein FAM13B isoform X3

    8. XM_054352761.1 → XP_054208736.1  protein FAM13B isoform X1

      UniProtKB/TrEMBL
      A0A8I5KSB9

    9. XM_054352769.1 → XP_054208744.1  protein FAM13B isoform X2

      UniProtKB/Swiss-Prot
      D3DQB5, G3V0H9, Q3ZCR0, Q6PGQ2, Q9NYF5, Q9P0I7
      UniProtKB/TrEMBL
      A0A2X0SG06

    10. XM_054352773.1 → XP_054208748.1  protein FAM13B isoform X4

    11. XM_054352763.1 → XP_054208738.1  protein FAM13B isoform X1

      UniProtKB/TrEMBL
      A0A8I5KSB9

    12. XM_054352774.1 → XP_054208749.1  protein FAM13B isoform X4

    13. XM_054352762.1 → XP_054208737.1  protein FAM13B isoform X1

      UniProtKB/TrEMBL
      A0A8I5KSB9

    14. XM_054352768.1 → XP_054208743.1  protein FAM13B isoform X2

      UniProtKB/Swiss-Prot
      D3DQB5, G3V0H9, Q3ZCR0, Q6PGQ2, Q9NYF5, Q9P0I7
      UniProtKB/TrEMBL
      A0A2X0SG06
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NYF5.2 GenPept UniProtKB/Swiss-Prot:Q9NYF5

    Gene LinkOut

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