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    OR1A1 olfactory receptor family 1 subfamily A member 1 [ Homo sapiens (human) ]

    Gene ID: 8383, updated on 10-Dec-2024

    Summary

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    Official Symbol
    OR1A1provided by HGNC
    Official Full Name
    olfactory receptor family 1 subfamily A member 1provided by HGNC
    Primary source
    HGNC:HGNC:8179
    See related
    Ensembl:ENSG00000172146 MIM:618046; AllianceGenome:HGNC:8179
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OR17-7
    Summary
    Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
    Orthologs
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    Genomic context

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    See OR1A1 in Genome Data Viewer
    Location:
    17p13.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (3207667..3218896)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (3095937..3107165)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (3110961..3122190)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100288728 Neighboring gene olfactory receptor family 1 subfamily P member 1 (gene/pseudogene) Neighboring gene olfactory receptor family 1 subfamily A member 2 Neighboring gene olfactory receptor family 1 subfamily D member 4 Neighboring gene olfactory receptor family 1 subfamily D member 3 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Third Extracellular Loop of Mammalian Odorant Receptors Is Involved in Ligand Binding. Shim T, et al. Int J Mol Sci, 2022 Oct 18. PMID 36293357, Free PMC Article
    2. Molecular mechanism of activation of human musk receptors OR5AN1 and OR1A1 by (R)-muscone and diverse other musk-smelling compounds. Ahmed L, et al. Proc Natl Acad Sci U S A, 2018 Apr 24. PMID 29632183, Free PMC Article
    3. Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2. Schmiedeberg K, et al. J Struct Biol, 2007 Sep. PMID 17601748
    4. Activation of OR1A1 suppresses PPAR-γ expression by inducing HES-1 in cultured hepatocytes. Wu C, et al. Int J Biochem Cell Biol, 2015 Jul. PMID 25817041
    5. Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. Glusman G, et al. Genomics, 2000 Jan 15. PMID 10673334

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Third Extracellular Loop of Mammalian Odorant Receptors Is Involved in Ligand Binding.
      Title: The Third Extracellular Loop of Mammalian Odorant Receptors Is Involved in Ligand Binding.
    2. Molecular mechanism of activation of human musk receptors OR5AN1 and OR1A1 by (R)-muscone and diverse other musk-smelling compounds.
      Title: Molecular mechanism of activation of human musk receptors OR5AN1 and OR1A1 by (R)-muscone and diverse other musk-smelling compounds.
    3. OR1A1 activation suppresses hepatic triglyceride metabolism by modulating HES-1, PPARG, and mtGPAT expression.
      Title: Activation of OR1A1 suppresses PPAR-γ expression by inducing HES-1 in cultured hepatocytes.
    4. Evolutionary conserved amino acid residues to be necessary for specific responsiveness of OR1A1 to odorants were identified.
      Title: Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables olfactory receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in detection of chemical stimulus involved in sensory perception of smell IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    olfactory receptor 1A1
    Names
    olfactory receptor 17-7
    olfactory receptor OR17-11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001386104.1 → NP_001373033.1  olfactory receptor 1A1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC090282
      Consensus CDS
      CCDS11022.1
      UniProtKB/Swiss-Prot
      A5D914, Q6IFM1, Q6NTA9, Q96R87, Q9P1Q5
      UniProtKB/TrEMBL
      A0A126GW88, A0A126GW98, A0A126GWA0, A0A126GWA2
      Related
      ENSP00000492897.1, ENST00000641322.1
      Conserved Domains (1) summary
      cd15235
      Location:24 → 299
      7tmA_OR1A-like; olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_014565.3 → NP_055380.2  olfactory receptor 1A1

      See identical proteins and their annotated locations for NP_055380.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC090282
      Consensus CDS
      CCDS11022.1
      UniProtKB/Swiss-Prot
      A5D914, Q6IFM1, Q6NTA9, Q96R87, Q9P1Q5
      UniProtKB/TrEMBL
      A0A126GW88, A0A126GW98, A0A126GWA0, A0A126GWA2
      Related
      ENSP00000493179.1, ENST00000641732.2
      Conserved Domains (1) summary
      cd15235
      Location:24 → 299
      7tmA_OR1A-like; olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      3207667..3218896
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      3095937..3107165
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9P1Q5.2 GenPept UniProtKB/Swiss-Prot:Q9P1Q5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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