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    SCRN1 secernin 1 [ Homo sapiens (human) ]

    Gene ID: 9805, updated on 27-Nov-2024

    Summary

    Official Symbol
    SCRN1provided by HGNC
    Official Full Name
    secernin 1provided by HGNC
    Primary source
    HGNC:HGNC:22192
    See related
    Ensembl:ENSG00000136193 MIM:614965; AllianceGenome:HGNC:22192
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SES1
    Summary
    This gene likely encodes a member of the secernin family of proteins. A similar protein in rat functions in regulation of exocytosis in mast cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]
    Expression
    Broad expression in brain (RPKM 69.1), testis (RPKM 17.1) and 22 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SCRN1 in Genome Data Viewer
    Location:
    7p14.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (29920103..29990289, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (30057799..30127994, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (29959719..30029905, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene DPY19L2 pseudogene 3 Neighboring gene zinc and ring finger 2 pseudogene 2 Neighboring gene Sharpr-MPRA regulatory region 13440 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:29823644-29824238 Neighboring gene hESC enhancers GRCh37_chr7:29832406-29833236 and GRCh37_chr7:29833237-29834066 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:29845860-29846769 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25802 Neighboring gene WAS/WASL interacting protein family member 3 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:29894186-29894764 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:29922848-29923743 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:29930193-29930732 Neighboring gene small nucleolar RNA U13 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:29968955-29969454 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:30000281-30001070 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18049 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18050 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18051 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18052 Neighboring gene FKBP14 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25803 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18053 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25804 Neighboring gene FKBP prolyl isomerase 14 Neighboring gene pleckstrin homology domain containing A8 Neighboring gene NANOG hESC enhancer GRCh37_chr7:30120436-30120962 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25805 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:30150426-30150612 Neighboring gene uncharacterized LOC105375216

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0193

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cysteine-type exopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables dipeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in exocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of synaptic vesicle cycle IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047114.1 RefSeqGene

      Range
      5489..75181
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001145513.1NP_001138985.1  secernin-1 isoform a

      See identical proteins and their annotated locations for NP_001138985.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein (isoform a).
      Source sequence(s)
      AA910381, AB071705, BC040492, DC307846
      Consensus CDS
      CCDS5422.1
      UniProtKB/Swiss-Prot
      A8K0E9, B4DHM0, B4DIP5, C9JPG0, Q12765, Q25QX7, Q8IWD1
      UniProtKB/TrEMBL
      A0A090N7T9
      Related
      ENSP00000409068.1, ENST00000426154.5
      Conserved Domains (1) summary
      cl00467
      Location:18227
      Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
    2. NM_001145514.1NP_001138986.1  secernin-1 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation at an alternate upstream start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is longer than isoform 1.
      Source sequence(s)
      AA910381, AB071705, AK295172
      Consensus CDS
      CCDS47567.1
      UniProtKB/Swiss-Prot
      Q12765
      Related
      ENSP00000388942.1, ENST00000434476.6
      Conserved Domains (1) summary
      cl41909
      Location:38247
      PepD; Dipeptidase [Amino acid transport and metabolism]
    3. NM_001145515.2NP_001138987.1  secernin-1 isoform c

      See identical proteins and their annotated locations for NP_001138987.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) is shorter than isoform 1.
      Source sequence(s)
      AA910381, AB071705, AK295713, DC370097
      Consensus CDS
      CCDS47568.1
      Related
      ENSP00000414245.2, ENST00000425819.6
      Conserved Domains (1) summary
      cl00467
      Location:2159
      Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
    4. NM_014766.5NP_055581.3  secernin-1 isoform a

      See identical proteins and their annotated locations for NP_055581.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein (isoform a).
      Source sequence(s)
      AA910381, AB071705, DC370097
      Consensus CDS
      CCDS5422.1
      UniProtKB/Swiss-Prot
      A8K0E9, B4DHM0, B4DIP5, C9JPG0, Q12765, Q25QX7, Q8IWD1
      UniProtKB/TrEMBL
      A0A090N7T9
      Related
      ENSP00000242059.5, ENST00000242059.10
      Conserved Domains (1) summary
      cl00467
      Location:18227
      Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      29920103..29990289 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047421085.1XP_047277041.1  secernin-1 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      30057799..30127994 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054359423.1XP_054215398.1  secernin-1 isoform X1