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    POLK DNA polymerase kappa [ Homo sapiens (human) ]

    Gene ID: 51426, updated on 27-Nov-2024

    Summary

    Official Symbol
    POLKprovided by HGNC
    Official Full Name
    DNA polymerase kappaprovided by HGNC
    Primary source
    HGNC:HGNC:9183
    See related
    Ensembl:ENSG00000122008 MIM:605650; AllianceGenome:HGNC:9183
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DINP; POLQ; DINB1
    Summary
    This gene encodes a member of the DNA polymerase type-Y family of proteins. The encoded protein is a specialized DNA polymerase that catalyzes translesion DNA synthesis, which allows DNA replication in the presence of DNA lesions. Human cell lines lacking a functional copy of this gene exhibit impaired genome integrity and enhanced susceptibility to oxidative damage. Mutations in this gene that impair enzyme activity may be associated with prostate cancer in human patients. [provided by RefSeq, Sep 2016]
    Expression
    Ubiquitous expression in thyroid (RPKM 6.4), testis (RPKM 4.9) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See POLK in Genome Data Viewer
    Location:
    5q13.3
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (75510774..75609991)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (75992960..76091061)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (74807716..74905816)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:74632956-74633516 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:74633517-74634075 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22679 Neighboring gene 3-hydroxy-3-methylglutaryl-CoA reductase Neighboring gene ReSE screen-validated silencer GRCh37_chr5:74675495-74675665 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:74683071-74684270 Neighboring gene ribosomal protein S26 pseudogene 26 Neighboring gene ceramide transporter 1 Neighboring gene MPRA-validated peak5292 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:74723894-74724394 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:74724395-74724895 Neighboring gene MPRA-validated peak5293 silencer Neighboring gene MPRA-validated peak5294 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22680 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22681 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:74832057-74832255 Neighboring gene RNA, U7 small nuclear 175 pseudogene Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:74861405-74862604 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22682 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22683 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:74884456-74885040 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:74905964-74906771 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:74906772-74907578 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:74907579-74908385 Neighboring gene ankyrin repeat and death domain containing 1B Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:74959194-74960393 Neighboring gene NANOG hESC enhancer GRCh37_chr5:74962804-74963305 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:74991871-74992409 Neighboring gene POC5 centriolar protein Neighboring gene RNA, U6 small nuclear 680, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-directed DNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in DNA repair IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in DNA repair TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to UV IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in error-prone translesion synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in error-prone translesion synthesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in nucleotide-excision repair, DNA gap filling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with site of DNA damage IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    DNA polymerase kappa
    Names
    polymerase (DNA directed) kappa
    NP_001332850.1
    NP_001332851.1
    NP_001374039.1
    NP_001374040.1
    NP_001374042.1
    NP_001382822.1
    NP_001382823.1
    NP_001382826.1
    NP_001382828.1
    NP_001382829.1
    NP_001382830.1
    NP_001382831.1
    NP_057302.1
    XP_054184385.1
    XP_054184386.1
    XP_054184387.1
    XP_054184388.1
    XP_054184389.1
    XP_054184390.1
    XP_054184391.1
    XP_054184392.1
    XP_054184393.1
    XP_054184394.1
    XP_054184395.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051590.2 RefSeqGene

      Range
      4861..98931
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001345921.3NP_001332850.1  DNA polymerase kappa isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC010245, AC026424, AC116341
      UniProtKB/TrEMBL
      Q59G18
      Conserved Domains (3) summary
      smart00734
      Location:555581
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd03586
      Location:38450
      PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
      cl02765
      Location:710736
      zf-WRNIP1_ubi; Werner helicase-interacting protein 1 ubiquitin-binding domain
    2. NM_001345922.3NP_001332851.1  DNA polymerase kappa isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC010245, AC026424, AC116341
      UniProtKB/TrEMBL
      Q59G18
      Conserved Domains (3) summary
      smart00734
      Location:531557
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd03586
      Location:14426
      PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
      cl02765
      Location:686712
      zf-WRNIP1_ubi; Werner helicase-interacting protein 1 ubiquitin-binding domain
    3. NM_001387110.3NP_001374039.1  DNA polymerase kappa isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC010245, AC026424, AC116341
      UniProtKB/TrEMBL
      Q59G18
      Conserved Domains (3) summary
      smart00734
      Location:618644
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd03586
      Location:104513
      PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
      cl02765
      Location:773799
      zf-WRNIP1_ubi; Werner helicase-interacting protein 1 ubiquitin-binding domain
    4. NM_001387111.3NP_001374040.1  DNA polymerase kappa isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC010245, AC026424, AC116341
      UniProtKB/TrEMBL
      Q59G18
      Conserved Domains (3) summary
      smart00734
      Location:635661
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd03586
      Location:104530
      PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
      cl02765
      Location:790816
      zf-WRNIP1_ubi; Werner helicase-interacting protein 1 ubiquitin-binding domain
    5. NM_001387113.3NP_001374042.1  DNA polymerase kappa isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC010245, AC026424, AC116341
      Consensus CDS
      CCDS4030.1
      UniProtKB/Swiss-Prot
      B2RBD2, Q5Q9G5, Q5Q9G6, Q5Q9G7, Q5Q9G8, Q86VJ8, Q8IZY0, Q8IZY1, Q8NB30, Q96L01, Q96Q86, Q96Q87, Q9UBT6, Q9UHC5
      UniProtKB/TrEMBL
      Q59G18
      Conserved Domains (3) summary
      smart00734
      Location:621647
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd03586
      Location:104516
      PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
      cl02765
      Location:776802
      zf-WRNIP1_ubi; Werner helicase-interacting protein 1 ubiquitin-binding domain
    6. NM_001395893.1NP_001382822.1  DNA polymerase kappa isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC010245, AC026424, AC116341
      UniProtKB/TrEMBL
      Q59G18
      Conserved Domains (3) summary
      smart00734
      Location:531557
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd03586
      Location:14426
      PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
      cl02765
      Location:686712
      zf-WRNIP1_ubi; Werner helicase-interacting protein 1 ubiquitin-binding domain
    7. NM_001395894.1NP_001382823.1  DNA polymerase kappa isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC010245, AC026424, AC116341
      UniProtKB/TrEMBL
      Q59G18
      Conserved Domains (3) summary
      smart00734
      Location:635661
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd03586
      Location:104530
      PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
      cl02765
      Location:790816
      zf-WRNIP1_ubi; Werner helicase-interacting protein 1 ubiquitin-binding domain
    8. NM_001395897.1NP_001382826.1  DNA polymerase kappa isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC010245, AC026424, AC116341
      UniProtKB/TrEMBL
      Q59G18
      Conserved Domains (3) summary
      smart00734
      Location:634660
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd03586
      Location:104529
      PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
      cl02765
      Location:789815
      zf-WRNIP1_ubi; Werner helicase-interacting protein 1 ubiquitin-binding domain
    9. NM_001395899.1NP_001382828.1  DNA polymerase kappa isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC010245, AC026424, AC116341
      UniProtKB/TrEMBL
      Q59G18
      Conserved Domains (3) summary
      smart00734
      Location:570596
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd03586
      Location:86465
      PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
      cl02765
      Location:725751
      zf-WRNIP1_ubi; Werner helicase-interacting protein 1 ubiquitin-binding domain
    10. NM_001395900.1NP_001382829.1  DNA polymerase kappa isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC010245, AC026424, AC116341
      UniProtKB/TrEMBL
      Q59G18
      Conserved Domains (3) summary
      smart00734
      Location:555581
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd03586
      Location:38450
      PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
      cl02765
      Location:710736
      zf-WRNIP1_ubi; Werner helicase-interacting protein 1 ubiquitin-binding domain
    11. NM_001395901.1NP_001382830.1  DNA polymerase kappa isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC010245, AC026424, AC116341
      UniProtKB/TrEMBL
      Q59G18
      Conserved Domains (3) summary
      smart00734
      Location:541567
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd03586
      Location:104436
      PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
      cl02765
      Location:696722
      zf-WRNIP1_ubi; Werner helicase-interacting protein 1 ubiquitin-binding domain
    12. NM_001395902.1NP_001382831.1  DNA polymerase kappa isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC010245, AC026424, AC116341
      UniProtKB/TrEMBL
      Q59G18
      Conserved Domains (3) summary
      smart00734
      Location:531557
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd03586
      Location:14426
      PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
      cl02765
      Location:686712
      zf-WRNIP1_ubi; Werner helicase-interacting protein 1 ubiquitin-binding domain
    13. NM_016218.6NP_057302.1  DNA polymerase kappa isoform 1

      See identical proteins and their annotated locations for NP_057302.1

      Status: REVIEWED

      Source sequence(s)
      AC010245, AC026424, AC116341
      Consensus CDS
      CCDS4030.1
      UniProtKB/Swiss-Prot
      B2RBD2, Q5Q9G5, Q5Q9G6, Q5Q9G7, Q5Q9G8, Q86VJ8, Q8IZY0, Q8IZY1, Q8NB30, Q96L01, Q96Q86, Q96Q87, Q9UBT6, Q9UHC5
      UniProtKB/TrEMBL
      Q59G18
      Related
      ENSP00000241436.4, ENST00000241436.9
      Conserved Domains (3) summary
      smart00734
      Location:621647
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd03586
      Location:104516
      PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
      cl02765
      Location:776802
      zf-WRNIP1_ubi; Werner helicase-interacting protein 1 ubiquitin-binding domain

    RNA

    1. NR_144315.3 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010245, AC026424, AC116341
    2. NR_170559.3 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010245, AC026424, AC116341
    3. NR_170560.3 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010245, AC026424, AC116341

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      75510774..75609991
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328411.1XP_054184386.1  DNA polymerase kappa isoform X1

    2. XM_054328417.1XP_054184392.1  DNA polymerase kappa isoform X2

      UniProtKB/Swiss-Prot
      B2RBD2, Q5Q9G5, Q5Q9G6, Q5Q9G7, Q5Q9G8, Q86VJ8, Q8IZY0, Q8IZY1, Q8NB30, Q96L01, Q96Q86, Q96Q87, Q9UBT6, Q9UHC5
    3. XM_054328410.1XP_054184385.1  DNA polymerase kappa isoform X1

    4. XM_054328412.1XP_054184387.1  DNA polymerase kappa isoform X1

    5. XM_054328419.1XP_054184394.1  DNA polymerase kappa isoform X4

      Related
      ENSP00000424174.1, ENST00000515295.5
    6. XM_054328413.1XP_054184388.1  DNA polymerase kappa isoform X1

    7. XM_054328416.1XP_054184391.1  DNA polymerase kappa isoform X2

      UniProtKB/Swiss-Prot
      B2RBD2, Q5Q9G5, Q5Q9G6, Q5Q9G7, Q5Q9G8, Q86VJ8, Q8IZY0, Q8IZY1, Q8NB30, Q96L01, Q96Q86, Q96Q87, Q9UBT6, Q9UHC5
    8. XM_054328415.1XP_054184390.1  DNA polymerase kappa isoform X1

    9. XM_054328414.1XP_054184389.1  DNA polymerase kappa isoform X1

    10. XM_054328418.1XP_054184393.1  DNA polymerase kappa isoform X3

    11. XM_054328420.1XP_054184395.1  DNA polymerase kappa isoform X5

    RNA

    1. XR_008485566.1 RNA Sequence

    2. XR_008485567.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      75992960..76091061
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001387112.1: Suppressed sequence

      Description
      NM_001387112.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.