GAL3ST3 galactose-3-O-sulfotransferase 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GAL3ST3provided by HGNC
Official Full Name: galactose-3-O-sulfotransferase 3provided by HGNC
Primary source: HGNC:HGNC:24144
See related: Ensembl:ENSG00000175229 MIM:608234; AllianceGenome:HGNC:24144
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GAL3ST2; GAL3ST-3
Summary: This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate group to the 3' position of galactose in N-acetyllactosamine in both type 2 (Gal-beta-1-4GlcNAc-R) oligosaccharides and core-2-branched O-glycans, but not on type 1 or core-1-branched structures. This gene, which has also been referred to as GAL3ST2, is different from the GAL3ST2 gene located on chromosome 2 that encodes a related enzyme with distinct tissue distribution and substrate specificities, compared to galactose-3-O-sulfotransferase 3. [provided by RefSeq, Jul 2008]
Expression: Biased expression in thyroid (RPKM 2.2), endometrium (RPKM 2.0) and 5 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q13.1

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (66040765..66049161, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (66034897..66043293, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (65808236..65816632, complement)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gal3ST-2 and LS180 sulfotransferase is a substrate for the globo H backbone; Gal3ST-3 is a substrate for N-glycan multiterminal Galbeta1
Title: Identification of physiologically relevant substrates for cloned Gal: 3-O-sulfotransferases (Gal3STs): distinct high affinity of Gal3ST-2 and LS180 sulfotransferase for the globo H backbone, Gal3ST-3 for N-glycan multiterminal Galbeta1, 4GlcNAcbeta units and 6-sulfoGalbeta1, 4GlcNAcbeta, and Gal3ST-4 for the mucin core-2 trisaccharide.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. EBI GWAS Catalog EBI GWAS CatalogPubMed
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S4064 (e-PCR)
- UniSTS:154161

D11S4418 (e-PCR)
- UniSTS:19687

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 3'-phosphoadenosine 5'-phosphosulfate binding	NAS Non-traceable Author Statement more info	PubMed
enables carbohydrate binding	NAS Non-traceable Author Statement more info	PubMed
enables galactose 3-O-sulfotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables galactose 3-O-sulfotransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables galactose 3-O-sulfotransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables galactosylceramide sulfotransferase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables proteoglycan sulfotransferase activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in glycolipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in monosaccharide metabolic process	NAS Non-traceable Author Statement more info	PubMed
involved_in oligosaccharide metabolic process	NAS Non-traceable Author Statement more info	PubMed
involved_in poly-N-acetyllactosamine metabolic process	NAS Non-traceable Author Statement more info	PubMed
involved_in proteoglycan biosynthetic process	NAS Non-traceable Author Statement more info	PubMed
involved_in sulfur compound metabolic process	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi cisterna membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: galactose-3-O-sulfotransferase 3

Names: beta-galactose-3-O-sulfotransferase 3; gal-beta-1, 3-GalNAc 3'-sulfotransferase 3; galactose 3'-sulfotransferase; galbeta1-3GalNAc 3'-sulfotransferase 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.