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    FCRL6 Fc receptor like 6 [ Homo sapiens (human) ]

    Gene ID: 343413, updated on 27-Nov-2024

    Summary

    Official Symbol
    FCRL6provided by HGNC
    Official Full Name
    Fc receptor like 6provided by HGNC
    Primary source
    HGNC:HGNC:31910
    See related
    Ensembl:ENSG00000181036 MIM:613562; AllianceGenome:HGNC:31910
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FcRH6
    Summary
    Enables MHC class II protein binding activity and protein phosphatase binding activity. Predicted to be involved in cell surface receptor signaling pathway and immune response. Located in external side of plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in spleen (RPKM 6.7), lung (RPKM 2.6) and 14 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See FCRL6 in Genome Data Viewer
    Location:
    1q23.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (159800512..159816257)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (158937524..158953270)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (159770302..159786047)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928264 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1454 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:159751068-159751644 Neighboring gene dual specificity phosphatase 23 Neighboring gene CRISPRi-validated cis-regulatory element chr1.9322 Neighboring gene Sharpr-MPRA regulatory region 9392 Neighboring gene uncharacterized LOC105371464 Neighboring gene SLAM family member 8 Neighboring gene small nucleolar RNA host gene 28 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:159815652-159816152 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:159816153-159816653 Neighboring gene small nucleolar RNA SNORD64

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat downregulates the expression of Fc receptor-like 6 (FCRL6) in human primary T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ16056

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables MHC class II protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    Fc receptor-like protein 6
    Names
    Fc receptor-like protein 7
    IFGP6
    IgSF type I transmembrane receptor
    fc receptor homolog 6
    fcR-like protein 6
    leukocyte receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004310.3NP_001004310.2  Fc receptor-like protein 6 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001004310.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer protein (isoform 1).
      Source sequence(s)
      AI631310, AK131201, AL590560, AY513661, DA959587
      Consensus CDS
      CCDS30912.1
      UniProtKB/Swiss-Prot
      A1KXW6, A2A4D6, Q6DN72, Q6DN73, Q6XRC3, Q6ZNI1
      Related
      ENSP00000357086.3, ENST00000368106.4
      Conserved Domains (4) summary
      cd05753
      Location:1998
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      smart00410
      Location:123198
      IG_like; Immunoglobulin like
      pfam13895
      Location:112200
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:206280
      Ig_3; Immunoglobulin domain
    2. NM_001284217.2NP_001271146.1  Fc receptor-like protein 6 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001271146.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus.
      Source sequence(s)
      AI631310, AK131201
      Consensus CDS
      CCDS60312.1
      UniProtKB/Swiss-Prot
      Q6DN72
      Related
      ENSP00000320625.6, ENST00000321935.10
      Conserved Domains (4) summary
      cd05753
      Location:26105
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      smart00410
      Location:130205
      IG_like; Immunoglobulin like
      pfam13895
      Location:119207
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:213287
      Ig_3; Immunoglobulin domain
    3. NM_001426231.1NP_001413160.1  Fc receptor-like protein 6 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AL590560
    4. NM_001426232.1NP_001413161.1  Fc receptor-like protein 6 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AL590560
    5. NM_001426233.1NP_001413162.1  Fc receptor-like protein 6 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL590560
    6. NM_001426234.1NP_001413163.1  Fc receptor-like protein 6 isoform 6 precursor

      Status: VALIDATED

      Source sequence(s)
      AL590560
      Related
      ENSP00000340949.5, ENST00000339348.9
    7. NM_001426235.1NP_001413164.1  Fc receptor-like protein 6 isoform 7 precursor

      Status: VALIDATED

      Source sequence(s)
      CP068277
    8. NM_001426236.1NP_001413165.1  Fc receptor-like protein 6 isoform 8 precursor

      Status: VALIDATED

      Source sequence(s)
      CP068277
    9. NM_001426237.1NP_001413166.1  Fc receptor-like protein 6 isoform 9

      Status: VALIDATED

      Source sequence(s)
      CP068277

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      159800512..159816257
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      158937524..158953270
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)