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    NCMAP non-compact myelin associated protein [ Homo sapiens (human) ]

    Gene ID: 400746, updated on 10-Dec-2024

    Summary

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    Official Symbol
    NCMAPprovided by HGNC
    Official Full Name
    non-compact myelin associated proteinprovided by HGNC
    Primary source
    HGNC:HGNC:29332
    See related
    Ensembl:ENSG00000184454 AllianceGenome:HGNC:29332
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MP11; C1orf130
    Summary
    Predicted to be a structural constituent of myelin sheath. Predicted to be involved in peripheral nervous system myelin formation and positive regulation of myelination. Predicted to be located in plasma membrane. Predicted to be active in Schmidt-Lanterman incisure and paranode region of axon. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in gall bladder (RPKM 3.2), thyroid (RPKM 2.0) and 12 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NCMAP in Genome Data Viewer
    Location:
    1p36.11
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (24556087..24609328)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (24394472..24447710)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (24882578..24935819)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 402 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:24828715-24828887 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 433 Neighboring gene MPRA-validated peak119 silencer Neighboring gene RCAN3 antisense RNA Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:24860519-24861170 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:24861821-24862472 Neighboring gene RCAN family member 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:24862473-24863122 Neighboring gene Sharpr-MPRA regulatory region 2491 Neighboring gene NCMAP divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:24894097-24894598 Neighboring gene NANOG hESC enhancer GRCh37_chr1:24895749-24896251 Neighboring gene ribosomal protein L26 pseudogene 8 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 434 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 405 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 435 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:24981406-24981591 Neighboring gene small nucleolar RNA U13 Neighboring gene serine and arginine repetitive matrix 1 Neighboring gene Sharpr-MPRA regulatory region 11281 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 436 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:25041190-25042389 Neighboring gene Sharpr-MPRA regulatory region 6401 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:25050611-25051418 Neighboring gene Sharpr-MPRA regulatory region 445 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:25056667-25057257 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:25069429-25070034 Neighboring gene hESC enhancers GRCh37_chr1:25071247-25071852 and GRCh37_chr1:25071853-25072458 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 439 Neighboring gene chloride intracellular channel 4 Neighboring gene RNA, U6 small nuclear 1208, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Analysis of peripheral nerve expression profiles identifies a novel myelin glycoprotein, MP11. Ryu EJ, et al. J Neurosci, 2008 Jul 23. PMID 18650334, Free PMC Article
    2. The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ42528

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables structural constituent of myelin sheath IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of myelin sheath ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in peripheral nervous system myelin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peripheral nervous system myelin formation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of myelination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Schmidt-Lanterman incisure IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Schmidt-Lanterman incisure ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in paranode region of axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in paranode region of axon ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    noncompact myelin-associated protein
    Names
    myelin protein of 11 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001010980.5 → NP_001010980.1  noncompact myelin-associated protein

      See identical proteins and their annotated locations for NP_001010980.1

      Status: VALIDATED

      Source sequence(s)
      AL445686, BC147014, CB961010
      Consensus CDS
      CCDS30632.1
      UniProtKB/Swiss-Prot
      A0PK04, B2RV34, Q5T1S8
      Related
      ENSP00000363513.2, ENST00000374392.3

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      24556087..24609328
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011541463.3 → XP_011539765.1  noncompact myelin-associated protein isoform X1

      See identical proteins and their annotated locations for XP_011539765.1

      UniProtKB/Swiss-Prot
      A0PK04, B2RV34, Q5T1S8

    2. XM_005245872.4 → XP_005245929.1  noncompact myelin-associated protein isoform X1

      See identical proteins and their annotated locations for XP_005245929.1

      UniProtKB/Swiss-Prot
      A0PK04, B2RV34, Q5T1S8
      Related
      ENST00000486262.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      24394472..24447710
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336573.1 → XP_054192548.1  noncompact myelin-associated protein isoform X2

    2. XM_054336574.1 → XP_054192549.1  noncompact myelin-associated protein isoform X1

      UniProtKB/Swiss-Prot
      A0PK04, B2RV34, Q5T1S8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5T1S8.1 GenPept UniProtKB/Swiss-Prot:Q5T1S8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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