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    Ikzf4 IKAROS family zinc finger 4 [ Mus musculus (house mouse) ]

    Gene ID: 22781, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ikzf4provided by MGI
    Official Full Name
    IKAROS family zinc finger 4provided by MGI
    Primary source
    MGI:MGI:1343139
    See related
    Ensembl:ENSMUSG00000002578 AllianceGenome:MGI:1343139
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Eos; Zfpn1a4; Znfn1a4; A630026H08Rik
    Summary
    Enables bHLH transcription factor binding activity and sequence-specific DNA binding activity. Acts upstream of or within negative regulation of DNA-templated transcription and positive regulation of transcription by RNA polymerase II. Predicted to be located in nuclear body. Predicted to be part of protein-containing complex. Is expressed in several structures, including central nervous system; dorsal root ganglion; genitourinary system; hemolymphoid system; and retina. Used to study encephalomyelitis. Orthologous to human IKZF4 (IKAROS family zinc finger 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in whole brain E14.5 (RPKM 4.1), CNS E14 (RPKM 4.1) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ikzf4 in Genome Data Viewer
    Location:
    10 D3; 10 77.11 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (128466708..128505668, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128630839..128669671, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5200 Neighboring gene predicted gene 9182 Neighboring gene STARR-positive B cell enhancer ABC_E904 Neighboring gene ribosomal protein S26 Neighboring gene predicted gene, 26876 Neighboring gene predicted gene, 51824 Neighboring gene STARR-positive B cell enhancer ABC_E2343 Neighboring gene sulfite oxidase Neighboring gene ribosomal protein L12 pseudogene Neighboring gene RAB5B, member RAS oncogene family

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CD4(+) regulatory T cells lacking Helios and Eos. Polak K, et al. Biochem Biophys Res Commun, 2023 Sep 24. PMID 37413709
    2. Selective deletion of Eos (Ikzf4) in T-regulatory cells leads to loss of suppressive function and development of systemic autoimmunity. Gokhale AS, et al. J Autoimmun, 2019 Dec. PMID 31296356, Free PMC Article
    3. Regulation of gene expression dynamics during developmental transitions by the Ikaros transcription factor. Arenzana TL, et al. Genes Dev, 2015 Sep 1. PMID 26314708, Free PMC Article
    4. Cytotoxic Programming of CD4+ T Cells Is Regulated by Opposing Actions of the Related Transcription Factors Eos and Aiolos. Jones DM, et al. J Immunol, 2024 Apr 1. PMID 38363226,
    5. Eos, MITF, and PU.1 recruit corepressors to osteoclast-specific genes in committed myeloid progenitors. Hu R, et al. Mol Cell Biol, 2007 Jun. PMID 17403896, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cytotoxic Programming of CD4+ T Cells Is Regulated by Opposing Actions of the Related Transcription Factors Eos and Aiolos.
      Title: Cytotoxic Programming of CD4+ T Cells Is Regulated by Opposing Actions of the Related Transcription Factors Eos and Aiolos.
    2. CD4[+] regulatory T cells lacking Helios and Eos.
      Title: CD4(+) regulatory T cells lacking Helios and Eos.
    3. Eos (lkzf4) appears to play an essential role in multiple aspects of Treg suppressor function.
      Title: Selective deletion of Eos (Ikzf4) in T-regulatory cells leads to loss of suppressive function and development of systemic autoimmunity.
    4. this study reports that IL-6 actively suppressed Eos mRNA and protein expression through miR-17
      Title: MicroRNA-17 Modulates Regulatory T Cell Function by Targeting Co-regulators of the Foxp3 Transcription Factor.
    5. Ikaros may not be a conventional activator or repressor of defined sets of genes, but may sharpen the dynamic range of gene expression changes during developmental transitions
      Title: Regulation of gene expression dynamics during developmental transitions by the Ikaros transcription factor.
    6. Eos is redundant for regulatory T cell function but plays an important role in IL-2 and IL-17 production by CD4+ conventional T cells.
      Title: Eos Is Redundant for Regulatory T Cell Function but Plays an Important Role in IL-2 and Th17 Production by CD4+ Conventional T Cells.
    7. Data indicate that miR-17 promotes TH17 differentiation by repressing target Ikaros Family Zinc Finger 4 (IKZF4).
      Title: miR-17-92 cluster targets phosphatase and tensin homology and Ikaros Family Zinc Finger 4 to promote TH17-mediated inflammation.
    8. We show that reprogramming is controlled by downregulation of the transcription factor Eos (Ikzf4), an obligate corepressor for Foxp3.
      Title: An inherently bifunctional subset of Foxp3+ T helper cells is controlled by the transcription factor eos.
    9. study identified Eos as a critical mediator of Foxp3-dependent gene silencing in CD4+ regulatory T cells (Tregs); Eos interacts directly with Foxp3 and induces chromatin modifications that result in gene silencing in Tregs
      Title: Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells.
    10. Data suggest that Eos, MITF, and PU.1 recruit corepressors to osteoclast-specific genes in committed myeloid progenitor cells.
      Title: Eos, MITF, and PU.1 recruit corepressors to osteoclast-specific genes in committed myeloid progenitors.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables bHLH transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein Eos
    Names
    ikaros family zinc finger protein 4
    zinc finger protein, subfamily 1A, 4 (Eos)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358536.2 → NP_001345465.1  zinc finger protein Eos isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2), as well as variant 3, encodes isoform 2.
      Source sequence(s)
      AC117232
      Conserved Domains (3) summary
      COG5189
      Location:156 → 216
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:106 → 126
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:146 → 171
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001358537.2 → NP_001345466.1  zinc finger protein Eos isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC117232
      Conserved Domains (3) summary
      COG5189
      Location:156 → 216
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:106 → 126
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:146 → 171
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001428880.1 → NP_001415809.1  zinc finger protein Eos isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), as well as variant 5, encodes isoform 3.
      Source sequence(s)
      AC117232

    4. NM_001428881.1 → NP_001415810.1  zinc finger protein Eos isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC117232

    5. NM_001428882.1 → NP_001415811.1  zinc finger protein Eos isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variant 7, encodes isoform 4.
      Source sequence(s)
      AC117232
      UniProtKB/TrEMBL
      A0A571BEH5

    6. NM_001428883.1 → NP_001415812.1  zinc finger protein Eos isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC117232
      UniProtKB/TrEMBL
      A0A571BEH5

    7. NM_001428884.1 → NP_001415813.1  zinc finger protein Eos isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC117232

    8. NM_011772.4 → NP_035902.2  zinc finger protein Eos isoform 1

      See identical proteins and their annotated locations for NP_035902.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC117232
      Consensus CDS
      CCDS24284.2
      UniProtKB/Swiss-Prot
      B9EJ21, Q3TCZ7, Q8C208, Q9Z2Z2
      Related
      ENSMUSP00000114404.2, ENSMUST00000133342.10
      Conserved Domains (2) summary
      sd00017
      Location:161 → 181
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:201 → 226
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      128466708..128505668 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155766.1 → XP_036011659.1  zinc finger protein Eos isoform X1

      Conserved Domains (3) summary
      COG5189
      Location:208 → 268
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:158 → 178
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:198 → 223
      zf-H2C2_2; Zinc-finger double domain

    2. XM_006513612.2 → XP_006513675.1  zinc finger protein Eos isoform X2

      Conserved Domains (3) summary
      COG5189
      Location:166 → 226
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:116 → 136
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:156 → 181
      zf-H2C2_2; Zinc-finger double domain

    3. XM_030245075.1 → XP_030100935.1  zinc finger protein Eos isoform X2

      Conserved Domains (3) summary
      COG5189
      Location:166 → 226
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:116 → 136
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:156 → 181
      zf-H2C2_2; Zinc-finger double domain

    4. XM_011243440.1 → XP_011241742.1  zinc finger protein Eos isoform X2

      See identical proteins and their annotated locations for XP_011241742.1

      Conserved Domains (3) summary
      COG5189
      Location:166 → 226
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:116 → 136
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:156 → 181
      zf-H2C2_2; Zinc-finger double domain

    5. XM_006513613.5 → XP_006513676.1  zinc finger protein Eos isoform X3

      Related
      ENSMUSP00000158702.2, ENSMUST00000238610.2
      Conserved Domains (3) summary
      COG5189
      Location:164 → 224
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:114 → 134
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:154 → 179
      zf-H2C2_2; Zinc-finger double domain

    6. XM_030245076.2 → XP_030100936.1  zinc finger protein Eos isoform X2

      Conserved Domains (3) summary
      COG5189
      Location:166 → 226
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:116 → 136
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:156 → 181
      zf-H2C2_2; Zinc-finger double domain

    7. XM_011243441.4 → XP_011241743.1  zinc finger protein Eos isoform X3

      Related
      ENSMUSP00000158614.2, ENSMUST00000238712.2
      Conserved Domains (3) summary
      COG5189
      Location:164 → 224
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:114 → 134
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:154 → 179
      zf-H2C2_2; Zinc-finger double domain

    8. XM_030245077.2 → XP_030100937.1  zinc finger protein Eos isoform X2

      Conserved Domains (3) summary
      COG5189
      Location:166 → 226
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:116 → 136
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:156 → 181
      zf-H2C2_2; Zinc-finger double domain

    9. XM_036155767.1 → XP_036011660.1  zinc finger protein Eos isoform X2

      Conserved Domains (3) summary
      COG5189
      Location:166 → 226
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:116 → 136
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:156 → 181
      zf-H2C2_2; Zinc-finger double domain

    10. XM_036155768.1 → XP_036011661.1  zinc finger protein Eos isoform X3

      UniProtKB/TrEMBL
      A0A571BEH5
      Conserved Domains (3) summary
      COG5189
      Location:164 → 224
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:114 → 134
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:154 → 179
      zf-H2C2_2; Zinc-finger double domain

    11. XM_006513616.4 → XP_006513679.1  zinc finger protein Eos isoform X5

      Conserved Domains (3) summary
      COG5189
      Location:109 → 169
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:59 → 79
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:99 → 124
      zf-H2C2_2; Zinc-finger double domain

    12. XM_030245078.2 → XP_030100938.1  zinc finger protein Eos isoform X4

      Related
      ENSMUSP00000152234.2, ENSMUST00000222067.2
      Conserved Domains (3) summary
      COG5189
      Location:156 → 216
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:106 → 126
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:146 → 171
      zf-H2C2_2; Zinc-finger double domain

    13. XM_030245074.2 → XP_030100934.1  zinc finger protein Eos isoform X2

      Conserved Domains (3) summary
      COG5189
      Location:166 → 226
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:116 → 136
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:156 → 181
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C208.2 GenPept UniProtKB/Swiss-Prot:Q8C208

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