Lztr1 leucine-zipper-like transcriptional regulator, 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lztr1provided by MGI
Official Full Name: leucine-zipper-like transcriptional regulator, 1provided by MGI
Primary source: MGI:MGI:1914113
See related: Ensembl:ENSMUSG00000022761 AllianceGenome:MGI:1914113
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1200003E21Rik
Summary: This gene encodes a member of the BR-C, ttk and bab-kelch superfamily that, in humans, localizes to the Golgi network and is associated with the ras / mitogen-activated protein kinase pathway. Loss-of-function mutations in the human ortholog are associated with glioblastoma multiforme, schwannomatosis, Noonan syndrome, and DiGeorge syndrome. [provided by RefSeq, Sep 2016]
Expression: Ubiquitous expression in ovary adult (RPKM 35.0), CNS E18 (RPKM 32.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 A3; 16 10.85 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (17326124..17344197)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (17508260..17526333)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologs.
Title: Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologs.
The Noonan Syndrome Gene Lztr1 Controls Cardiovascular Function by Regulating Vesicular Trafficking.
Title: The Noonan Syndrome Gene Lztr1 Controls Cardiovascular Function by Regulating Vesicular Trafficking.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI840249 (e-PCR)
- UniSTS:165979

Lztr1 (e-PCR), detects polymorphism
- UniSTS:547257

AI591627 (e-PCR)
- UniSTS:164599

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables small GTPase binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in negative regulation of Ras protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of Ras protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Cul3-RING ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of Cul3-RING ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in endomembrane system	ISO Inferred from Sequence Orthology more info
located_in endomembrane system	ISS Inferred from Sequence or Structural Similarity more info
located_in recycling endosome membrane	ISO Inferred from Sequence Orthology more info
located_in recycling endosome membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: leucine-zipper-like transcriptional regulator 1

Names: LZTR-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001331226.1 → NP_001318155.1 leucine-zipper-like transcriptional regulator 1 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains a distinct 5' UTR, lacks an in-frame portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.

Source sequence(s)

AK004561, BF457766, BY005614, BY146849

UniProtKB/TrEMBL

A0A338P6P0
NM_001331227.1 → NP_001318156.1 leucine-zipper-like transcriptional regulator 1 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate splice site at an internal exon and initiates translation from a downstream start codon compared to variant 1. It encodes isoform 3 which has a shorter N-terminus compared to isoform 1.

Source sequence(s)

AC113006, AK004561, BF457766

UniProtKB/Swiss-Prot

Q9CQ33

Conserved Domains (8) summary

PLN02153
Location:1 → 107

PLN02153; epithiospecifier protein

sd00038
Location:45 → 146

Kelch; KELCH repeat [structural motif]

cd18308
Location:181 → 332

BTB1_POZ_LZTR1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)

cd18309
Location:408 → 533

BTB2_POZ_LZTR1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)

cd18505
Location:336 → 394

BACK1_LZTR1; first BACK (BTB and C-terminal Kelch) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)

cd18506
Location:529 → 589

BACK2_LZTR1; second BACK (BTB and C-terminal Kelch) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)

pfam01344
Location:44 → 87

Kelch_1; Kelch motif

pfam03089
Location:128 → 181

RAG2; Recombination activating protein 2
NM_025808.4 → NP_080084.2 leucine-zipper-like transcriptional regulator 1 isoform 1

See identical proteins and their annotated locations for NP_080084.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC113006, AK004561, BF457766

Consensus CDS

CCDS37272.1

UniProtKB/Swiss-Prot

Q9CQ33

UniProtKB/TrEMBL

A0A338P6P0

Related

ENSMUSP00000023444.4, ENSMUST00000023444.11

Conserved Domains (7) summary

smart00225
Location:665 → 762

BTB; Broad-Complex, Tramtrack and Bric a brac

cd14821
Location:571 → 631

SPOP_C_like; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins

sd00038
Location:65 → 111

Kelch; KELCH repeat [structural motif]

pfam00651
Location:662 → 761

BTB; BTB/POZ domain

pfam01344
Location:280 → 323

Kelch_1; Kelch motif

pfam13415
Location:74 → 123

Kelch_3; Galactose oxidase, central domain

pfam13418
Location:171 → 217

Kelch_4; Galactose oxidase, central domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

17326124..17344197

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006522477.3 → XP_006522540.1 leucine-zipper-like transcriptional regulator 1 isoform X1

UniProtKB/TrEMBL

Q3V0X6

Conserved Domains (6) summary

PLN02153
Location:65 → 347

PLN02153; epithiospecifier protein

sd00038
Location:65 → 111

Kelch; KELCH repeat [structural motif]

cd18308
Location:417 → 568

BTB1_POZ_LZTR1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)

cd18505
Location:572 → 630

BACK1_LZTR1; first BACK (BTB and C-terminal Kelch) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)

cl38908
Location:644 → 686

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

pfam03089
Location:364 → 417

RAG2; Recombination activating protein 2
XM_030249246.1 → XP_030105106.1 leucine-zipper-like transcriptional regulator 1 isoform X3

UniProtKB/TrEMBL

A0A338P6Y5

Conserved Domains (5) summary

cd18308
Location:84 → 235

BTB1_POZ_LZTR1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)

cd18309
Location:311 → 436

BTB2_POZ_LZTR1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)

cd18505
Location:239 → 297

BACK1_LZTR1; first BACK (BTB and C-terminal Kelch) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)

cd18506
Location:432 → 492

BACK2_LZTR1; second BACK (BTB and C-terminal Kelch) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)

pfam03089
Location:31 → 84

RAG2; Recombination activating protein 2
XM_017317119.2 → XP_017172608.1 leucine-zipper-like transcriptional regulator 1 isoform X2

Conserved Domains (8) summary

PLN02153
Location:1 → 107

PLN02153; epithiospecifier protein

sd00038
Location:45 → 146

Kelch; KELCH repeat [structural motif]

cd18308
Location:181 → 332

BTB1_POZ_LZTR1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)

cd18309
Location:408 → 533

BTB2_POZ_LZTR1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)

cd18505
Location:336 → 394

BACK1_LZTR1; first BACK (BTB and C-terminal Kelch) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)

cd18506
Location:529 → 589

BACK2_LZTR1; second BACK (BTB and C-terminal Kelch) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)

pfam01344
Location:44 → 87

Kelch_1; Kelch motif

pfam03089
Location:128 → 181

RAG2; Recombination activating protein 2
XM_017317121.2 → XP_017172610.1 leucine-zipper-like transcriptional regulator 1 isoform X3

UniProtKB/TrEMBL

A0A338P6Y5

Conserved Domains (5) summary

cd18308
Location:84 → 235

BTB1_POZ_LZTR1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)

cd18309
Location:311 → 436

BTB2_POZ_LZTR1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)

cd18505
Location:239 → 297

BACK1_LZTR1; first BACK (BTB and C-terminal Kelch) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)

cd18506
Location:432 → 492

BACK2_LZTR1; second BACK (BTB and C-terminal Kelch) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)

pfam03089
Location:31 → 84

RAG2; Recombination activating protein 2
XM_017317120.2 → XP_017172609.1 leucine-zipper-like transcriptional regulator 1 isoform X3

UniProtKB/TrEMBL

A0A338P6Y5

Related

ENSMUSP00000156018.2, ENSMUST00000231307.2

Conserved Domains (5) summary

cd18308
Location:84 → 235

BTB1_POZ_LZTR1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)

cd18309
Location:311 → 436

BTB2_POZ_LZTR1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)

cd18505
Location:239 → 297

BACK1_LZTR1; first BACK (BTB and C-terminal Kelch) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)

cd18506
Location:432 → 492

BACK2_LZTR1; second BACK (BTB and C-terminal Kelch) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)

pfam03089
Location:31 → 84

RAG2; Recombination activating protein 2