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    Stxbp4 syntaxin binding protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 20913, updated on 9-Dec-2024

    Summary

    Official Symbol
    Stxbp4provided by MGI
    Official Full Name
    syntaxin binding protein 4provided by MGI
    Primary source
    MGI:MGI:1342296
    See related
    Ensembl:ENSMUSG00000020546 AllianceGenome:MGI:1342296
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Synip; 6030470M02Rik
    Summary
    Predicted to enable syntaxin binding activity. Acts upstream of or within several processes, including cellular response to type II interferon; insulin receptor signaling pathway; and regulation of D-glucose transmembrane transport. Located in phagocytic vesicle. Orthologous to human STXBP4 (syntaxin binding protein 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 1.5), limb E14.5 (RPKM 1.3) and 26 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Stxbp4 in Genome Data Viewer
    Location:
    11 D; 11 55.04 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (90367318..90528962, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (90476492..90638136, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene hepatic leukemia factor Neighboring gene STARR-seq mESC enhancer starr_30412 Neighboring gene STARR-seq mESC enhancer starr_30414 Neighboring gene predicted gene, 34850 Neighboring gene STARR-seq mESC enhancer starr_30415 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:90386757-90386940 Neighboring gene eukaryotic translation initiation factor 2C, 2 pseudogene Neighboring gene cytochrome c oxidase assembly protein 11, copper chaperone Neighboring gene target of myb1-like 1 (chicken) Neighboring gene STARR-positive B cell enhancer mm9_chr11:90559162-90559463 Neighboring gene predicted gene, 34938

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Spontaneous (1)  1 citation
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables syntaxin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables syntaxin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables syntaxin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to type II interferon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in insulin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within insulin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell cycle G1/S phase transition IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell cycle G1/S phase transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of keratinocyte proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of keratinocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein stabilization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein targeting IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of D-glucose transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of insulin secretion involved in cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in phagocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    syntaxin-binding protein 4
    Names
    STX4-interacting protein
    syntaxin 4-interacting protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011505.3NP_035635.1  syntaxin-binding protein 4

      See identical proteins and their annotated locations for NP_035635.1

      Status: VALIDATED

      Source sequence(s)
      AL646046
      Consensus CDS
      CCDS25242.1
      UniProtKB/Swiss-Prot
      Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1, Q9WV89
      Related
      ENSMUSP00000116191.2, ENSMUST00000143203.8
      Conserved Domains (3) summary
      cd00992
      Location:2194
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:502531
      WW; WW domain
      pfam08467
      Location:189393
      Luteo_P1-P2; Luteovirus RNA polymerase P1-P2/replicase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      90367318..90528962 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245750.2XP_030101610.1  syntaxin-binding protein 4 isoform X6

      Conserved Domains (2) summary
      TIGR02169
      Location:75240
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam00397
      Location:277306
      WW; WW domain
    2. XM_006532736.5XP_006532799.1  syntaxin-binding protein 4 isoform X1

      Related
      ENSMUSP00000020858.8, ENSMUST00000020858.14
      Conserved Domains (2) summary
      cd00992
      Location:2194
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR02169
      Location:300465
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    3. XM_006532738.5XP_006532801.1  syntaxin-binding protein 4 isoform X3

      Conserved Domains (2) summary
      cd00992
      Location:2194
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR02169
      Location:300465
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    4. XM_006532737.5XP_006532800.1  syntaxin-binding protein 4 isoform X2

      Conserved Domains (2) summary
      cd00992
      Location:2194
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR02169
      Location:300465
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    5. XM_006532739.5XP_006532802.1  syntaxin-binding protein 4 isoform X4

      Conserved Domains (1) summary
      cd00992
      Location:2194
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    6. XM_006532740.5XP_006532803.1  syntaxin-binding protein 4 isoform X5

      Conserved Domains (1) summary
      cd00992
      Location:2194
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    RNA

    1. XR_388390.4 RNA Sequence