Elavl4 ELAV like RNA binding protein 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Elavl4provided by MGI
Official Full Name: ELAV like RNA binding protein 4provided by MGI
Primary source: MGI:MGI:107427
See related: Ensembl:ENSMUSG00000028546 AllianceGenome:MGI:107427
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hud; Elav; PNEM
Summary: Enables mRNA binding activity. Acts upstream of or within learning; locomotory behavior; and neuron differentiation. Located in axon; cytoplasm; and dendrite. Is expressed in several structures, including central nervous system; enteric nervous system; eye; intestine; and urogenital sinus. Orthologous to human ELAVL4 (ELAV like RNA binding protein 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in CNS E14 (RPKM 18.2), whole brain E14.5 (RPKM 17.9) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 C7; 4 51.42 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (110060934..110209127, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (110203737..110351939, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RNA binding protein HuD mediates the crosstalk between beta cells and islet endothelial cells by the regulation of Endostatin and Serpin E1 expression.
Title: RNA binding protein HuD mediates the crosstalk between β cells and islet endothelial cells by the regulation of Endostatin and Serpin E1 expression.
Loss of RNA binding protein HuD facilitates the production of the senescence-associated secretory phenotype.
Title: Loss of RNA binding protein HuD facilitates the production of the senescence-associated secretory phenotype.
ALS-related FUS mutations alter axon growth in motoneurons and affect HuD/ELAVL4 and FMRP activity.
Title: ALS-related FUS mutations alter axon growth in motoneurons and affect HuD/ELAVL4 and FMRP activity.
RNA binding protein HuD contributes to beta-cell dysfunction by impairing mitochondria dynamics.
Title: RNA binding protein HuD contributes to β-cell dysfunction by impairing mitochondria dynamics.
The RNA-Binding Protein HuD Regulates Alternative Splicing and Alternative Polyadenylation in the Mouse Neocortex.
Title: The RNA-Binding Protein HuD Regulates Alternative Splicing and Alternative Polyadenylation in the Mouse Neocortex.
The RNA-binding protein, HuD regulates proglucagon biosynthesis in pancreatic alpha cells.
Title: The RNA-binding protein, HuD regulates proglucagon biosynthesis in pancreatic α cells.
RNA-seq analysis of mouse neocortical polysomes demonstrated that the translation of distinct mRNA isoforms of the RNA binding protein (RBP), Elavl4, in radial glia progenitors and early neurons depends on its alternative 5' UTRs. 5' UTR-driven Elavl4 isoform-specific translation depends on upstream control by another RBP, Celf1. Celf1 regulation of Elavl4 translation dictates development of glutamatergic neurons.
Title: Translational derepression of Elavl4 isoforms at their alternative 5' UTRs determines neuronal development.
HuD and miR-203a cooperatively regulate INSM1 expression.
Title: RNA binding protein HuD and microRNA-203a cooperatively regulate insulinoma-associated 1 mRNA.
HuD enhanced p27 mRNA translation by interacting with both the 5'-untranslated region (UTR) and the 3'-UTR of p27 mRNA, and consequently suppressed cell cycle progression and growth of pancreatic neuroendocrine tumors.
Title: Reduced expression of the RNA-binding protein HuD in pancreatic neuroendocrine tumors correlates with low p27(Kip1) levels and poor prognosis.
we demonstrated HuD downregulation and HuB upregulation in DRG sensory neurons induced by diabetes, which might be correlated with altered post-transcriptional control of RNAs involved in the regulation of thermal hypoalgesia condition caused by the advanced diabetic neuropathy.
Title: RNA-Binding Proteins HuB, HuC, and HuD are Distinctly Regulated in Dorsal Root Ganglia Neurons from STZ-Sensitive Compared to STZ-Resistant Diabetic Mice.

Submit: New GeneRIF Correction See all GeneRIFs (37)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC337033P2 (e-PCR)
- UniSTS:273166

RH131794 (e-PCR)
- UniSTS:215077

BB464020 (e-PCR)
- UniSTS:207658

Elavl4 (e-PCR), detects polymorphism
- UniSTS:143435

Elavl4 (e-PCR), detects polymorphism
- UniSTS:479108

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables mRNA 3'-UTR AU-rich region binding	ISO Inferred from Sequence Orthology more info
enables mRNA 3'-UTR AU-rich region binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA 3'-UTR binding	ISO Inferred from Sequence Orthology more info
enables mRNA 3'-UTR binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables poly(A) binding	ISO Inferred from Sequence Orthology more info
enables poly(A) binding	ISS Inferred from Sequence or Structural Similarity more info
enables pre-mRNA intronic pyrimidine-rich binding	ISO Inferred from Sequence Orthology more info
enables pre-mRNA intronic pyrimidine-rich binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in 3'-UTR-mediated mRNA stabilization	ISO Inferred from Sequence Orthology more info
involved_in 3'-UTR-mediated mRNA stabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in RNA processing	ISO Inferred from Sequence Orthology more info
involved_in RNA processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in associative learning	IEA Inferred from Electronic Annotation more info
involved_in cellular response to nerve growth factor stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cerebral cortex neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within learning	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of 3'-UTR-mediated mRNA stabilization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of 3'-UTR-mediated mRNA stabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of dendrite development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dendrite development	ISO Inferred from Sequence Orthology more info
involved_in regeneration	IEA Inferred from Electronic Annotation more info
involved_in regulation of mRNA stability	ISO Inferred from Sequence Orthology more info
involved_in regulation of translation at postsynapse	IEA Inferred from Electronic Annotation more info
involved_in regulation of translation at postsynapse	ISO Inferred from Sequence Orthology more info
involved_in response to cocaine	IEA Inferred from Electronic Annotation more info
involved_in response to endoplasmic reticulum stress	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical dendrite	IEA Inferred from Electronic Annotation more info
located_in apical dendrite	ISO Inferred from Sequence Orthology more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in growth cone	IEA Inferred from Electronic Annotation more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
located_in ribosome	IEA Inferred from Electronic Annotation more info
located_in ribosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ELAV-like protein 4

Names: ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D); HU-antigen D; RNA-binding protein HUD3; paraneoplastic encephalomyelitis antigen HuD

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001038698.2 → NP_001033787.1 ELAV-like protein 4 isoform b

Status: VALIDATED

Source sequence(s)

AL627206, AL627425

Consensus CDS

CCDS18470.1

UniProtKB/TrEMBL

Q9CXQ0

Related

ENSMUSP00000099784.5, ENSMUST00000102723.11

Conserved Domains (1) summary

TIGR01661
Location:43 → 379

ELAV_HUD_SF; ELAV/HuD family splicing factor
NM_001163397.2 → NP_001156869.1 ELAV-like protein 4 isoform c

Status: VALIDATED

Source sequence(s)

AL627206, AL627425

Consensus CDS

CCDS51262.1

UniProtKB/TrEMBL

Q9CXQ0

Related

ENSMUSP00000102214.3, ENSMUST00000106603.9

Conserved Domains (1) summary

TIGR01661
Location:46 → 355

ELAV_HUD_SF; ELAV/HuD family splicing factor
NM_001163399.2 → NP_001156871.1 ELAV-like protein 4 isoform d

Status: VALIDATED

Source sequence(s)

AL627206, AL627425

Consensus CDS

CCDS51261.1

UniProtKB/TrEMBL

Q9CXQ0

Related

ENSMUSP00000099783.3, ENSMUST00000102722.9

Conserved Domains (1) summary

TIGR01661
Location:48 → 370

ELAV_HUD_SF; ELAV/HuD family splicing factor
NM_001347178.1 → NP_001334107.1 ELAV-like protein 4 isoform e

Status: VALIDATED

Description

Transcript Variant: This variant (5) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (e) has the same N- and C-termini but is shorter compared to isoform a.

Source sequence(s)

AL627206, AL627425

Consensus CDS

CCDS84777.1

UniProtKB/TrEMBL

Q9CXQ0

Related

ENSMUSP00000102208.2, ENSMUST00000106598.8

Conserved Domains (1) summary

TIGR01661
Location:43 → 365

ELAV_HUD_SF; ELAV/HuD family splicing factor
NM_001357190.2 → NP_001344119.1 ELAV-like protein 4 isoform f

Status: VALIDATED

Source sequence(s)

AL627206, AL627425

UniProtKB/TrEMBL

Q9CXQ0

Conserved Domains (1) summary

TIGR01661
Location:41 → 363

ELAV_HUD_SF; ELAV/HuD family splicing factor
NM_001421151.1 → NP_001408080.1 ELAV-like protein 4 isoform g

Status: VALIDATED

Source sequence(s)

AL627206, AL627425
NM_001421152.1 → NP_001408081.1 ELAV-like protein 4 isoform g

Status: VALIDATED

Source sequence(s)

AL627206, AL627425
NM_001421153.1 → NP_001408082.1 ELAV-like protein 4 isoform e

Status: VALIDATED

Source sequence(s)

AL627206, AL627425
NM_001421154.1 → NP_001408083.1 ELAV-like protein 4 isoform e

Status: VALIDATED

Source sequence(s)

AL627206, AL627425

Related

ENSMUSP00000102212.2, ENSMUST00000106601.8
NM_001421155.1 → NP_001408084.1 ELAV-like protein 4 isoform h

Status: VALIDATED

Source sequence(s)

AL627206, AL627425
NM_001421156.1 → NP_001408085.1 ELAV-like protein 4 isoform i

Status: VALIDATED

Source sequence(s)

AL627206, AL627425
NM_001421157.1 → NP_001408086.1 ELAV-like protein 4 isoform j

Status: VALIDATED

Source sequence(s)

AL627206, AL627425
NM_001421158.1 → NP_001408087.1 ELAV-like protein 4 isoform k

Status: VALIDATED

Source sequence(s)

AL627206, AL627425
NM_001421159.1 → NP_001408088.1 ELAV-like protein 4 isoform m

Status: VALIDATED

Source sequence(s)

AL627206, AL627425
NM_001421160.1 → NP_001408089.1 ELAV-like protein 4 isoform n

Status: VALIDATED

Source sequence(s)

AL627206, AL627425
NM_001421161.1 → NP_001408090.1 ELAV-like protein 4 isoform o

Status: VALIDATED

Source sequence(s)

AL627206, AL627425

Related

ENSMUSP00000102210.3, ENSMUST00000106600.9
NM_001421162.1 → NP_001408091.1 ELAV-like protein 4 isoform p

Status: VALIDATED

Source sequence(s)

AL627206, AL627425
NM_001421163.1 → NP_001408092.1 ELAV-like protein 4 isoform q

Status: VALIDATED

Source sequence(s)

AL627206, AL627425
NM_001421164.1 → NP_001408093.1 ELAV-like protein 4 isoform r

Status: VALIDATED

Source sequence(s)

AL627206, AL627425
NM_001421165.1 → NP_001408094.1 ELAV-like protein 4 isoform s

Status: VALIDATED

Source sequence(s)

AL627206, AL627425
NM_001421166.1 → NP_001408095.1 ELAV-like protein 4 isoform o

Status: VALIDATED

Source sequence(s)

AL627206, AL627425
NM_001421167.1 → NP_001408096.1 ELAV-like protein 4 isoform t

Status: VALIDATED

Source sequence(s)

AL627206, AL627425
NM_001421168.1 → NP_001408097.1 ELAV-like protein 4 isoform u

Status: VALIDATED

Source sequence(s)

AL627206, AL627425
NM_010488.5 → NP_034618.2 ELAV-like protein 4 isoform a

Status: VALIDATED

Source sequence(s)

AL627206, AL627425

Consensus CDS

CCDS18471.1

UniProtKB/Swiss-Prot

A2A9R6, A2A9R7, A2A9R8, A2A9S0, A2A9S1, A2A9S2, A2A9S3, O55010, Q61701, Q6PHZ3, Q8BVA9

UniProtKB/TrEMBL

Q9CXQ0

Related

ENSMUSP00000102207.4, ENSMUST00000106597.10

Conserved Domains (1) summary

TIGR01661
Location:48 → 384

ELAV_HUD_SF; ELAV/HuD family splicing factor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

110060934..110209127 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006502800.4 → XP_006502863.1 ELAV-like protein 4 isoform X9

UniProtKB/TrEMBL

Q9CXQ0

Conserved Domains (1) summary

TIGR01661
Location:43 → 379

ELAV_HUD_SF; ELAV/HuD family splicing factor
XM_030253255.2 → XP_030109115.1 ELAV-like protein 4 isoform X19

UniProtKB/TrEMBL

Q9CXQ0

Conserved Domains (1) summary

TIGR01661
Location:58 → 367

ELAV_HUD_SF; ELAV/HuD family splicing factor
XM_006502794.5 → XP_006502857.1 ELAV-like protein 4 isoform X2

UniProtKB/TrEMBL

Q9CXQ0

Conserved Domains (1) summary

TIGR01661
Location:58 → 394

ELAV_HUD_SF; ELAV/HuD family splicing factor
XM_006502803.5 → XP_006502866.1 ELAV-like protein 4 isoform X17

UniProtKB/TrEMBL

Q9CXQ0

Conserved Domains (1) summary

TIGR01661
Location:60 → 369

ELAV_HUD_SF; ELAV/HuD family splicing factor
XM_036163730.1 → XP_036019623.1 ELAV-like protein 4 isoform X4

UniProtKB/TrEMBL

Q9CXQ0

Conserved Domains (1) summary

TIGR01661
Location:50 → 386

ELAV_HUD_SF; ELAV/HuD family splicing factor
XM_036163731.1 → XP_036019624.1 ELAV-like protein 4 isoform X10

UniProtKB/TrEMBL

Q9CXQ0

Conserved Domains (1) summary

TIGR01661
Location:56 → 379

ELAV_HUD_SF; ELAV/HuD family splicing factor
XM_006502797.5 → XP_006502860.1 ELAV-like protein 4 isoform X5

UniProtKB/TrEMBL

Q9CXQ0

Conserved Domains (1) summary

TIGR01661
Location:60 → 383

ELAV_HUD_SF; ELAV/HuD family splicing factor